The emergence of ectomesenchyme

Blentic, Aida; Tandon, Panna; Payton, Sarah; Walshe, Jennifer; Carney, Thomas J.; Kelsh, Robert N.; Mason, Ivor; Graham, Anthony

doi:10.1002/dvdy.21439

Cited by 72 publications

(75 citation statements)

References 46 publications

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“…With the observed timing of the requirement for Fgf signaling around 30 hpf, this observation could explain the somewhat weaker effects observed upon Fgfr2 depletion. Earlier requirement for Fgf signaling in cNCCs during segmentation (Blentic et al, 2008) suggests the presence of an Fgf receptor at this stage in cNCCs, however the exact nature of this receptor was not determined.…”

Section: Fgfr1a and Fgfr2 Control The Function Of Pharyngeal Endodermmentioning

confidence: 98%

“…Fgf3 and Fgf8 ligands produced in the hindbrain and lateral mesoderm are required during early segmentation stages for correct organization of the endodermal pouches (Crump et al, 2004). Later, Fgf signaling is required in cNCCs for their conversion into the ectomesenchymal lineage, characterized by dlx2a expression, after migration into the endodermal pouches (Blentic et al, 2008). Endodermal expression of fgf3 is required for dlx2a expression in post migratory cNCCs and their survival in the posterior arches (David et al, 2002;Nissen et al, 2003), while loss of function of both fgf3 and fgf8 affect differentiation and survival of cNCCs as well as dlx2a expression in all the arches (Crump et al, 2004;Walshe and Mason, 2003).…”

Section: The Receptors Fgfr1a and Fgfr2 Are Required For Late Differementioning

confidence: 99%

“…formation of the pharyngeal arches (Blentic et al, 2008;Crump et al, 2004), it seems surprising that the effects of fgfr1a or fgfr2 knockdown are not more severe. Indeed, the general morphology of the morphants was not much affected, brain segmentation was normal, patterning of the pharyngeal endoderm was close to normal and the first markers for chondrocyte differentiation are present.…”

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Fgf receptors Fgfr1a and Fgfr2 control the function of pharyngeal endoderm in late cranial cartilage development

et al. 2013

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Section: Fgfr1a and Fgfr2 Control The Function Of Pharyngeal Endodermmentioning

confidence: 98%

Section: The Receptors Fgfr1a and Fgfr2 Are Required For Late Differementioning

confidence: 99%

mentioning

confidence: 99%

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Fgf receptors Fgfr1a and Fgfr2 control the function of pharyngeal endoderm in late cranial cartilage development

et al. 2013

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“…An extensive body of evidence has shown that pigment cells, peripheral neurons and glia share a common precursor with ectomesenchymal derivatives within cranial neural folds (Baroffio et al, 1991;Blentic et al, 2008;Chan and Tam, 1988;Essex et al, 1993;Osumi-Yamashita et al, 1994;Pohl and Knöchel, 2001). More recent experiments in the mouse mapped the cranial neural fold territory with greater spatial and temporal resolution, and led to the controversial proposal of a distinct origin (the metablast) for ectomesenchyme (Breau et al, 2008;Weston et al, 2004).…”

Section: Research Articlementioning

confidence: 99%

An exclusively mesodermal origin of fin mesenchyme demonstrates that zebrafish trunk neural crest does not generate ectomesenchyme

et al. 2013

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SUMMARYThe neural crest is a multipotent stem cell population that arises from the dorsal aspect of the neural tube and generates both nonectomesenchymal (melanocytes, peripheral neurons and glia) and ectomesenchymal (skeletogenic, odontogenic, cartilaginous and connective tissue) derivatives. In amniotes, only cranial neural crest generates both classes, with trunk neural crest restricted to nonectomesenchyme. By contrast, it has been suggested that anamniotes might generate derivatives of both classes at all axial levels, with trunk neural crest generating fin osteoblasts, scale mineral-forming cells and connective tissue cells; however, this has not been fully tested. The cause and evolutionary significance of this cranial/trunk dichotomy, and its absence in anamniotes, are debated. Recent experiments have disputed the contribution of fish trunk neural crest to fin osteoblasts and scale mineral-forming cells. This prompted us to test the contribution of anamniote trunk neural crest to fin connective tissue cells. Using genetics-based lineage tracing in zebrafish, we find that these fin mesenchyme cells derive entirely from the mesoderm and that neural crest makes no contribution. Furthermore, contrary to previous suggestions, larval fin mesenchyme cells do not generate the skeletogenic cells of the adult fin, but persist to form fibroblasts associated with adult fin rays. Our data demonstrate that zebrafish trunk neural crest does not generate ectomesenchymal derivatives and challenge long-held ideas about trunk neural crest fate. These findings have important implications for the ontogeny and evolution of the neural crest.

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“…Anthony Graham (MRC Centre for Developmental Neurobiology, King's College London, UK) and colleagues (Blentic et al, 2008) have been exploring the interactions that occur between the neural crest and the pharyngeal epithelia. As Graham discussed, they have (Depew and Olsson, 2008).…”

Section: Factors Involved In Face Patterningmentioning

confidence: 99%

On the trail of the `new head' in Les Treilles

Bronner‐Fraser

2008

Development

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The vertebrate brain develops in association with neighboring tissues: neural crest, placodes, mesoderm and endoderm. The molecular and evolutionary relationships between the forming nervous system and the other craniofacial structures were at the focus of a recent meeting at the Fondation des Treilles in France. Entitled 'Relationships between Craniofacial and Neural Development', the meeting brought together researchers working on diverse species, the findings of whom provide clues as to the origin and diversity of the brain and facial regions that are involved in forming the 'new head' of vertebrates. IntroductionThe vertebrate brain develops in close association with neighboring tissues, including cells from the neural crest, mesoderm and endoderm, such that their development is interlinked and interdependent. Together, these tissues form the central and peripheral nervous systems and the craniofacial skeleton of the vertebrate head. A recent meeting at the Fondation des Treilles in Provence, organized by Sophie Creuzet

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The emergence of ectomesenchyme

Cited by 72 publications

References 46 publications

Fgf receptors Fgfr1a and Fgfr2 control the function of pharyngeal endoderm in late cranial cartilage development

Fgf receptors Fgfr1a and Fgfr2 control the function of pharyngeal endoderm in late cranial cartilage development

An exclusively mesodermal origin of fin mesenchyme demonstrates that zebrafish trunk neural crest does not generate ectomesenchyme

On the trail of the `new head' in Les Treilles

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