The end of triglycerides in cardiovascular risk assessment?

Sattar, Naveed; Cj, Packard; Petrie,

doi:10.1136/bmj.317.7158.553

Cited by 18 publications

(7 citation statements)

References 13 publications

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“…OLETF rats are known to exhibit hypertriglyceridemia, which is largely responsible for obesity and cardiovascular disease (Sattar et al, 1998;Nakaya et al, 2002;Mori et al, 2005). We observed that OLETF controls had 4.3 times higher plasma triglyceride levels than LETO controls.…”

Section: Discussionmentioning

confidence: 70%

The Korean traditional medicine Gyeongshingangjeehwan inhibits obesity through the regulation of leptin and PPARα action in OLETF rats

Jeong

Chae

Jung

et al. 2008

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 70%

The Korean traditional medicine Gyeongshingangjeehwan inhibits obesity through the regulation of leptin and PPARα action in OLETF rats

Jeong

Chae

Jung

et al. 2008

Journal of Ethnopharmacology

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“…Triglyceride concentration has also been linked to coronary heart disease and stroke in prospective studies, and recent observations have supported the notion that there may be a clinically relevant interaction between cholesterol and triglycerides in the risk of coronary heart disease [5, 6]. In addition, there exists a strong association between triglyceride and insulin resistance.…”

Section: Introductionmentioning

confidence: 89%

Low Triglyceride, Not Low Cholesterol Concentration, Independently Predicts Poor Outcome following Acute Stroke

Weir

Sattar²,

Walters

et al. 2003

Cerebrovasc Dis

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Background: Recent data have shown an unexpected association between poor outcome after acute stroke and lower serum cholesterol. Triglyceride concentration has been linked to coronary heart disease and stroke; however, there are currently no data on the relationship between triglyceride and stroke outcome. Such information may yield further mechanistic information on the relationship between lipids and stroke outcome. Methods: We studied 1,310 nondiabetic patients presenting to our acute stroke unit with computed tomography-confirmed acute stroke. Fasting blood samples were drawn within 24 h of admission for glucose, lipids and a standard battery of biochemistry and hematological tests. Information on age, stroke type, admission blood pressure, smoking status, presence of atrial fibrillation, resolution time of symptoms and Oxfordshire Community Stroke Project clinical classification was collated. Stepwise proportional hazards regression was used to estimate the effect of the above variables on survival following stroke. Results: Increased age (p < 0.0001), presence of atrial fibrillation (p = 0.009), hyperglycemia (p = 0.0005) and lower triglyceride level (p < 0.0001) independently predicted higher mortality; early resolution of symptoms (p = 0.005) independently predicted lower mortality. Although serum cholesterol level predicted outcome after adjusting for other prognostic factors, it did not remain significant when triglyceride level was entered into the model. The relative hazard per additional quartile of triglyceride was 0.84 (95% confidence interval 0.77–0.91). Conclusions: Low triglyceride concentration strongly predicts higher mortality following stroke, whereas serum cholesterol level is not an independent predictor. Outcome following stroke is thus related more strongly to triglyceride-rich than to cholesterol-rich lipoprotein concentrations. The mechanisms explaining this require further investigation.

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“…Moreover, these two fibrates have been demonstrated to effectively decrease postprandial triglyceride levels [37, 38]. In addition, fibrates can increase HDL cholesterol, decrease nonlipid risk factors for cardiovascular disease (for example, elevated fibrinogen levels), modify plasminogen activator inhibitor‐1 (PAI‐1), and have no adverse effect on glycaemic control, all of which have a beneficial effect in preventing atherosclerosis [4, 19]. Statins act mainly on total and LDL cholesterol levels, with less efficacy on triglyceride and HDL cholesterol levels.…”

Section: Management Of Postprandial Hyperinsulinaemia and Hypertriglymentioning

confidence: 99%

“…The importance of measuring postprandial triglyceride abnormalities Results from prospective, observational studies con®rm the independent predictive value of triglycerides in assessing cardiovascular risk [18,19]. However, despite the atherogenic potential of postprandial particles, the monitoring of postprandial triglyceride levels is not carried out routinely in daily clinical practice.…”

Section: The Lipid Pro®le In Syndrome Xmentioning

confidence: 99%

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Are postprandial triglyceride and insulin abnormalities neglected cardiovascular risk factors in type 2 diabetes?

Golay

2000

Eur J Clin Investigation

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The end of triglycerides in cardiovascular risk assessment?

Cited by 18 publications

References 13 publications

The Korean traditional medicine Gyeongshingangjeehwan inhibits obesity through the regulation of leptin and PPARα action in OLETF rats

The Korean traditional medicine Gyeongshingangjeehwan inhibits obesity through the regulation of leptin and PPARα action in OLETF rats

Low Triglyceride, Not Low Cholesterol Concentration, Independently Predicts Poor Outcome following Acute Stroke

Are postprandial triglyceride and insulin abnormalities neglected cardiovascular risk factors in type 2 diabetes?

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