The Enhancement Effect of Castor Oil on the Permeability of Flurbiprofen as Transdermal Gel

Alaayedi, Maryam; Mahmood, Hasanain; Saeed, Ashti M. H.

doi:10.22159/ijap.2018v10i1.23348

Cited by 5 publications

(7 citation statements)

References 9 publications

(12 reference statements)

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“…These standards are designed to establish the allowed packaging processes and propose a sustainable extraction and allowed processes [109][110][111][112]. Various challenges in formulating herbal cosmetics have been overcome through various novel delivery systems [113][114].…”

Section: Discussionmentioning

confidence: 99%

Challenges in Formulating Herbal Cosmetics

D.k.

Jain

2018

Int J App Pharm

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The herbal cosmetics are prepared by phytochemicals that occur in a variety of botanical sources, that influences the physiology of skin and provide nutrients that are necessary for the healthy skin or hair. These products are utilized for daily purposes, which include herbal shampoo, herbal conditioner, herbal face wash, herbal soap, etc. These products are classified as a different category by regulatory agencies. However, guidelines of these certifying agencies have no harmonization, and many cosmetic industries prepare and package these formulations in an irrationalway. Many cosmetic products have natural products in their formulation that perform a specific biological function, but these products should be evaluated on their toxicological and efficacy aspects. The contribution of developing countries is very poor in global herbal business because of lack of standardization measures and quality control. The lack of safety and efficacy data on herbal cosmetics renders it difficult to meet the criteria needed for supporting its use worldwide. This review article discusses challenges related to regulatory status, quality control, standardization, certification, drug processing and the opportunities for herbal cosmetics in local as well as the global scenario. The search criteria used in the present review were the keywords mentioned in the manuscript and articles from major scientific resources were cited. The articles from 1952 to 2018 were specifically referred, but few references from 19 century were also cited to support the prevalence of scientific principles in the development of herbal cosmetics in the ancient era.

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Section: Discussionmentioning

confidence: 99%

Challenges in Formulating Herbal Cosmetics

D.k.

Jain

2018

Int J App Pharm

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“…The weight of the container before and after filling it with gel was noted. In order to achieve a practical yield, the weight of the empty container was reduced from the weight of the container with gel [24].…”

Section: Percentage Yieldmentioning

confidence: 99%

“…Then, the pH was determined by using a digital Elico pH meter. The pH measurements for each formulation were done in triplicate and the average values were calculated [23,24].…”

Section: Drug Contentmentioning

confidence: 99%

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Development and Evaluation of Itraconazole Solid Dispersion Gel Cutaneous Delivery

MADHAVI,

SUDHAKAR,

SRAVANI

2023

Int J App Pharm

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Objective: The objective of this research is to enhance the permeation of low bioavailable drugs with suitable dosage forms by utilizing various permeation enhancers. Methods: Solid dispersions (SDs) were prepared by kneading, whereas physical mixtures (PM) were prepared by simple mixing with polymers PEG 6000 and PEG 20000 and evaluated for various physicochemical parameters. Optimized SDs were converted to gels using a variety of polymers and were evaluated for in vitro and ex vivo permeation studies. Results: It was found that the percentage of drugs in SDs and PMs was within the limit. The dissolution of SDs and PMs was found to be the highest with PEG-6000 (99.78% within 240 min) compared to PEG 20000. The maximum drug release (92.9% within 8 h) was achieved with oleic acid in both in vitro and ex vivo permeation studies, as evidenced by the in vitro and ex vivo permeation studies. The developed formulations showed no incompatibility between drugs and excipients, as demonstrated by drug and excipient interaction studies. Conclusion: The results that were observed confirmed that the itraconazole PEG-6000 gel developed has promising effects on desirable skin permeation.

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“…Dermis is the layer of skin beneath the epidermis contains blood vessels, lymph vessels, and nerves. The two main routes of skin permeation are transepidermal route and transfollicular route [2,3]. Wound healing is a complex process that occurs in tissues after damage.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Cefixime Trihydrate Topical Gel for Wound Infections

Srinivasan

Vishnu

Sharmila

et al. 2018

Asian J Pharm Clin Res

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Objective: The objective of this research work was to formulate and evaluate topical gel loaded with cefixime trihydrate, a third-generation cephalosporin antibiotic for the treatment of bacterial wound infections. Methods:The cefixime trihydrate gel was formulated using polymers such as Carbopol 940 and hydroxypropyl methylcellulose E4M in varying concentrations. Three different formulations were prepared and characterized physically for color, syneresis, spreadability, pH, drug content, and rheological properties. In vitro drug release in phosphate buffer pH 7.4 and antibacterial study were performed for the gel formulation to evaluate its therapeutic effect on wound infections. Results:The study demonstrated that the gel formulations showed promising results on their physical evaluation tests. The rheology behavior of the gel was shear-thinning flow type which indicated easy spreading of the gel. The drug release of the gel formulation F2 was selected as the best due to its highest drug release rate of 32.2% in comparison with the other two formulations after 2 h of the study. F2 formulation possessed the highest antibacterial activity as compared to other two formulations. Conclusion:A pioneering work was done on formulating cefixime trihydrate as a gel for topical administration. The antibacterial effect of the drug as gel formulation showed promising effect. We conclude that the cefixime trihydrate could be successively loaded into a gel formulation and can be used for effectively for wound infections like diabetic foot wounds.

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The Enhancement Effect of Castor Oil on the Permeability of Flurbiprofen as Transdermal Gel

Cited by 5 publications

References 9 publications

Challenges in Formulating Herbal Cosmetics

Challenges in Formulating Herbal Cosmetics

Development and Evaluation of Itraconazole Solid Dispersion Gel Cutaneous Delivery

Formulation and Evaluation of Cefixime Trihydrate Topical Gel for Wound Infections

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