The epidemiology of quantitative ultrasound: A review of the relationships with bone mass, osteoporosis and fracture risk

Gregg, Edward W.; Kriska, Andrea M.; Salamone, L; Roberts, Michelle; Anderson, Stewart J.; Ferrell, Robert E.; Kuller, Lewis H.; Cauley, Jane A.

doi:10.1007/bf01623682

Cited by 233 publications

(143 citation statements)

References 79 publications

Supporting

Mentioning

126

Contrasting

Unclassified

Order By: Relevance

“…These correlation coefficients are on the low end of those reported for other QUS devices. 3,21 A poor correlation between QUS at the calcaneus and axial BMD does not necessarily imply poor diagnostic sensitivity. Large prospective studies as well as cross-sectional studies have shown that QUS at the calcaneus is as good as hip BMD at hip fracture prediction.…”

Section: Correlationsmentioning

confidence: 99%

“…Large prospective studies as well as cross-sectional studies have shown that QUS at the calcaneus is as good as hip BMD at hip fracture prediction. 3,24,25 The lack of correlation between QUS at the calcaneus and axial BMD has been attributed to many factors: precision and accuracy errors, biological discordance, and different interaction mechanisms. 26 Higher correlations have been observed between QUS and calcaneal BMD (r = 0.66-0.80).…”

Section: Correlationsmentioning

confidence: 99%

“…In previous in vivo studies of hip fracture prediction, the diagnostic sensitivity of QUS at the calcaneus has been shown to be similar to that of hip BMD and superior to that of lumbar spine BMD. 3 There are currently various QUS systems clinically available. Each system differs in the coupling medium (water or gel), the measuring site (calcaneus, phalanges, or radius), algorithm (BUA, SOS, or both), and transducer size.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of a gel‐coupled quantitative ultrasound device for bone status assessment.

Njeh

Chen

Fan

et al. 2001

J of Ultrasound Medicine

View full text Add to dashboard Cite

Objective. To evaluate a new gel-coupled calcaneal quantitative ultrasound system, Osteospace (Medilink, Montpellier, France), which was designed to assess the status of bone in the calcaneus. Methods. The study group consisted of 215 healthy white women aged 20 to 85 years and 51 white women aged 60 to 86 years with osteoporotic fractures. Fifty-two healthy women aged 50 to 85 years were randomly selected from the healthy cohort as the control group. All the women had calcaneal quantitative ultrasonic measurements. The women with osteoporotic fractures and the control group also had proximal femur and lumbar anteroposterior spine bone mineral density measurements using dual X-ray absorptiometry. Bone mineral density was also measured in a subgroup of 54 women at the calcaneus. Results. There was a significant inverse correlation of broadband ultrasound attenuation and speed of sound with age (P < .001). Short-term measurement precision values expressed as coefficients of variation were 1.72% for broadband ultrasound attenuation and 0.64% for speed of sound, and standardized shortterm precision values were 6.09% for broadband ultrasound attenuation and 3.87% for speed of sound. The correlations between the quantitative ultrasonic parameters and calcaneal bone mineral density were 0.69 (P = .0001) for broadband ultrasound attenuation and 0.45 (P = .0008) for speed of sound. Both quantitative ultrasonic parameters and all bone mineral density measurements of the hip and spine differed significantly between the control and osteoporotic fracture groups (P < .01). Age-, weight-, and height-adjusted odds ratios per SD decrease were as follows: broadband ultrasound attenuation, 1.79; speed of sound, 1.83; spine bone mineral density, 2.34; femoral neck bone mineral density, 1.69; and total hip bone mineral density, 1.85. The areas under the receiver operating characteristic curve for quantitative ultrasound parameters and bone mineral density measurements were close, ranging from 0.75 to 0.80. Conclusions. This new quantitative ultrasound system can detect age-and menopause-related influences on skeletal status and can discriminate healthy women from those with osteoporotic fractures in a manner comparable with that of bone mineral density measurement by dual X-ray absorptiometry. Key words: fracture; osteoporosis; precision; quantitative ultrasound; speed of sound; broadband ultrasound attenuation. Bone and Mineral Research, September 30-October 4, 1999, St Louis, Missouri, and September 22-26, 2000, Toronto, Ontario, Canada. Address correspondence and reprint requests to Christopher F. Njeh, PhD, Osteoporosis and Arthritis Research Group, Department of Radiology, University of California San Francisco, 350 Parnassus Ave, Suite 607, San Francisco, CA 94143-1349. Abbreviations BMD, bone mineral density; BUA, broadband ultrasound attenuation; CV, coefficient of variation; DXA, dual X-ray absorptiometry; OR, odds ratio; QUS, quantitative ultrasound; ROI, region of interest; SOS, speed of sound

show abstract

Section: Correlationsmentioning

confidence: 99%

Section: Correlationsmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of a gel‐coupled quantitative ultrasound device for bone status assessment.

Njeh

Chen

Fan

et al. 2001

J of Ultrasound Medicine

View full text Add to dashboard Cite

show abstract

“…The majority of bone ultrasonic testers are heel QUS apparatuses [1] measuring the ultrasound velocity and broadband frequency slope of attenuation by through propagation mode in the volume of os calceus dominantly composed of spongeous bone. Axial QUS has a special place among QUS techniques, presenting the advantage of unilateral positioning of the probe in available sites of long bones covered by a thin layer of soft tissues [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Use of multiple acoustic wave modes for assessment of long bones: Model study

Tatarinov

Sarvazyan

2005

Ultrasonics

View full text Add to dashboard Cite

Multiple acoustic wave mode method has been proposed as a new modality in axial bone QUS. The new method is based on measurement of ultrasound velocity at different ratio of wavelength to the bone thickness, and taking into account both bulk and guided waves. It allows assessment of changes in both the material properties related to porosity and mineralization as well as the cortical thickness influenced by resorption from inner layers, which are equally important in diagnostics of osteoporosis and other bone osteopenia. Developed method was validated in model studies using a dual-frequency (100 and 500 kHz) ultrasound device. Three types of bone phantoms for long bones were developed and tested: (1) tubular specimens from polymer materials to model combined changes of material stiffness and cortical wall thickness; (2) layered specimens to model porosity in compact bone progressing from endosteum towards periosteum; (3) animal bone specimens with both cortical and trabecular components. Observed changes of the ultrasound velocity of guided waves at 100 kHz followed gradual changes in the thickness of the intact cortical layer. On the other hand, the bulk velocity at 500 kHz remained nearly constant at the different cortical layer thickness but was affected by the material stiffness. Similar trends were observed in phantoms and in fragments of animal bones.

show abstract

“…A este respecto, la determinación en el calcáneo podría inducir sesgos al soportar excesiva presión, aunque para algunos autores es la preferente 21 . La exploración con US en las falanges ofrece algunas ventajas 22 : por un lado, son fácilmente accesibles y están constituidas por hueso Nutrición infantil y salud ósea 80.e3 compacto y cortical (el más implicado en la osteoporosis).…”

Section: Article In Pressunclassified

Nutrición infantil y salud ósea

Franch

Río

Cortina

2010

Anales de Pediatría

View full text Add to dashboard Cite

PALABRAS CLAVENutrición; Osteoporosis; Salud ósea; Pico de masa ósea; Infancia ResumenMantener un adecuado estado nutricional en todas las etapas de la vida es decisivo para lograr un metabolismo óseo que favorezca la salud. La osteoporosis se caracteriza por una alteración en la cantidad y calidad de la mineralización ósea, lo que origina una fragilidad del esqueleto con riesgo aumentado de fracturas, especialmente vertebrales y de cadera. Es un problema público a nivel mundial, que afecta a una proporción elevada de hombres y mujeres, y que se desarrolla de forma asintomática hasta que se manifiesta de forma imprevista y causa una fractura del esqueleto. Estudios en niños han demostrado que el desarrollo de osteoporosis en la edad adulta puede verse condicionada por el estado nutricional durante la infancia, especialmente en lo referente a los aportes de calcio y vitamina D. No obstante, existen aún muchas cuestiones abiertas, tanto en lo referente a su patogenia y diagnóstico como a su tratamiento; algunas de éstas se revisan en este trabajo. & 2009 Asociación Española de Pediatría. Publicado por Elsevier España, S.L. Todos los derechos reservados. KEYWORDSNutrition; Osteoporosis; Bone health; Peak bone mass; Children Nutrition and bone health in children Abstract Adequate nutrient intake is an important component of maintaining bone health, and should be encouraged in all age groups. Osteoporosis is a disease in which the density and quality of bone are reduced, leading to weakness of the skeleton and increased risk of fracture, particularly of the spine and hip. Osteoporosis is a global public health problem which currently affects a great proportion of women and men, and is increasing in significance as the population of the world both grows in size and lives longer. Bone loss does not have any symptoms, and often the first sign of having osteoporosis is a fracture.

show abstract

The epidemiology of quantitative ultrasound: A review of the relationships with bone mass, osteoporosis and fracture risk

Cited by 233 publications

References 79 publications

Evaluation of a gel‐coupled quantitative ultrasound device for bone status assessment.

Evaluation of a gel‐coupled quantitative ultrasound device for bone status assessment.

Use of multiple acoustic wave modes for assessment of long bones: Model study

Nutrición infantil y salud ósea

Contact Info

Product

Resources

About