The Epidemiology of Vitreoretinal Interface Abnormalities as Detected by Spectral-Domain Optical Coherence Tomography

Meuer, Stacy M.; Myers, Chelsea E.; Klein, Barbara E.K.; Swift, Maria; Huang, Yijun; Gangaputra, Sapna; Pak, Jeong W.; Danis, Ronald P.; Klein, Ronald

doi:10.1016/j.ophtha.2014.10.014

Cited by 213 publications

(196 citation statements)

References 30 publications

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“…However, Meuer et al. (2015) found no significant difference according to sex after adjustment for age. The prevalence was significantly higher with age (1.2% in individuals of 40 to 49 years and 15.5% in individuals of 70 years and older).…”

Section: Discussionmentioning

confidence: 94%

“…The Beaver Dam Eye Study, however, showed a much higher prevalence of 34.1% (Meuer et al. 2015). Both studies confirm an increasing prevalence with increasing age (Mitchell et al.…”

Section: Discussionmentioning

confidence: 99%

“…2009; Meuer et al. 2015). In addition, we found no association with sex, as previously shown in the Beaver dam Eye Study (Meuer et al.…”

Section: Discussionmentioning

confidence: 99%

“…The Beaver Dam Eye Study also reported a low prevalence of 0.5% (Meuer et al. 2015). As there were no participants with macular holes and only two participants with a pseudohole, we were not able to make valid calculations of the prevalence about these two disorders.…”

Section: Discussionmentioning

confidence: 99%

“…1994; Meuer et al. 2015), the Baltimore Eye Study (Rahmani et al. 1996), the Beijing Eye Study (Wang et al.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of optical coherence tomography detected vitreomacular interface disorders: The Maastricht Study

Liesenborghs

Clerck

Berendschot

et al. 2018

Acta Ophthalmologica

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PurposeTo calculate the prevalence of all vitreomacular interface (VMI) disorders and stratify according to age, sex and (pre)diabetes status.MethodsThe presence of VMI disorders was assessed in 2660 participants aged between 40 and 75 years from The Maastricht Study who had a gradable macular spectral‐domain optical coherence tomography (SD‐OCT) volume scan in at least one eye [mean 59.7 ± 8.2 years, 50.2% men, 1531 normal glucose metabolism (NGM), 401 prediabetes, 728 type 2 diabetes (DM2, oversampled)]. A stratified and multivariable logistic regression analysis was used.ResultsThe prevalence of the different VMI disorders for individuals with NGM, prediabetes and DM2 was, respectively, 5.7%, 6% and 6.7% for epiretinal membranes; 6%, 9.6% and 6.8% for vitreomacular traction; 1.1%, 0.7% and 0.3% for lamellar macular holes; 0.1%, 0% and 0% for pseudoholes; 1.1%, 1.9% and 5.5% for macular cysts. None of the participants was diagnosed with a macular hole. The prevalence of epiretinal membranes, vitreomacular traction and macular cysts was higher with age (p < 0.001). Vitreomacular traction and lamellar macular holes were more frequent in women (p < 0.01). DM2 is positively associated [OR = 3.9 (95% CI 2.11–7.22, p < 0.001)] with macular cysts and negatively associated with lamellar macular holes [OR = 0.2 (95% CI 0.04–0.9, p = 0.036)] after adjustment for age and sex. The calculated prevalence of VMI disorders was 15.9%.ConclusionsThe calculated prevalence of VMI disorders in individuals aged between 40 and 75 years is 15.9%. The prevalence depends on age, sex and glucose metabolism status for several types of VMI disorders.

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Section: Discussionmentioning

confidence: 94%

“…The Beaver Dam Eye Study, however, showed a much higher prevalence of 34.1% (Meuer et al. 2015). Both studies confirm an increasing prevalence with increasing age (Mitchell et al.…”

Section: Discussionmentioning

confidence: 99%

“…2009; Meuer et al. 2015). In addition, we found no association with sex, as previously shown in the Beaver dam Eye Study (Meuer et al.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…1994; Meuer et al. 2015), the Baltimore Eye Study (Rahmani et al. 1996), the Beijing Eye Study (Wang et al.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of optical coherence tomography detected vitreomacular interface disorders: The Maastricht Study

Liesenborghs

Clerck

Berendschot

et al. 2018

Acta Ophthalmologica

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Exploring Sex and Laterality Imbalances in Patients Undergoing Laser Retinopexy

et al. 2015

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Incidence of and Risk Factors for Developing Idiopathic Macular Hole Among a Diverse Group of Patients Throughout the United States

et al. 2017

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IMPORTANCE Idiopathic macular holes (MHs) are a cause of decreased vision among older Americans. A better understanding of risk factors for MH may help clarify the pathophysiologic factors of MH and identify potential new avenues for preventing and treating idiopathic MHs. OBJECTIVE To determine the incidence of and risk factors associated with the development of idiopathic MH requiring surgical repair with vitrectomy among a large group of managed care plan beneficiaries throughout the United States. DESIGN, SETTING, AND PARTICIPANTS A retrospective, longitudinal cohort study was conducted of all beneficiaries 40 years or older who were continuously enrolled for 3 or more years in a nationwide US managed care network between January 1, 2001, and December 31, 2012, who had 2 or more visits to an eye care professional. The managed care network was queried starting in 2009, and data analysis was conducted from December 1, 2014, to August 15, 2016. MAIN OUTCOMES AND MEASURES Development of idiopathic MH requiring surgical repair with vitrectomy. RESULTS Of the 659 357 enrollees who met inclusion criteria (391 674 females and 267 683 males; mean [SD] age, 56.2 [9.2] years), 144 (0.02%) developed an MH requiring vitrectomy.After adjusting for confounding factors, females had a 64% increased risk of developing MH compared with males (adjusted hazard ratio, 1.64; 95% CI, 1.11-2.43; P = .01), with the effect of sex varying across ages. Compared with white participants, Asian-American enrollees had a 177% increased risk of developing MH (adjusted hazard ratio, 2.77; 95% CI, 1.27-6.02; P = .01). CONCLUSIONS AND RELEVANCEIn this large cohort, sex was confirmed to be associated with developing an MH requiring vitrectomy; the effect varies across ages differently for females vs males. These differences may be the basis for the underlying pathophysiologic factors contributing to the development of MH.

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The Epidemiology of Vitreoretinal Interface Abnormalities as Detected by Spectral-Domain Optical Coherence Tomography

Cited by 213 publications

References 30 publications

Prevalence of optical coherence tomography detected vitreomacular interface disorders: The Maastricht Study

Prevalence of optical coherence tomography detected vitreomacular interface disorders: The Maastricht Study

Exploring Sex and Laterality Imbalances in Patients Undergoing Laser Retinopexy

Incidence of and Risk Factors for Developing Idiopathic Macular Hole Among a Diverse Group of Patients Throughout the United States

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