The estrogen receptor 1 gene affects bone mineral density and osteoporosis treatment efficiency in Slovak postmenopausal women

Mondockova, Vladimira; Adamkovičová, Mária; Lukáčová, Martina; Großkopf, Birgit; Babošová, Ramona; Galbavy, Drahomir; Martiniaková, Monika; Omelka, Radoslav

doi:10.1186/s12881-018-0684-8

Cited by 30 publications

(23 citation statements)

References 47 publications

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“…Additionally, the importance of ERs on cortical and trabecular bone, and also in different bone cell types have been widely explored (42). Although the studied genetic polymorphism rs2234693 and rs9340799 in ESR1 and rs1256049 and rs4986938 were not associated with PAP in the present study, they were previously associated with many different bone conditions (28,43) and oral conditions (43)(44)(45). The genetic polymorphisms rs2234693 and rs9340799 in ESR1 have been largely studied.…”

Section: Discussionmentioning

confidence: 61%

“…The genetic polymorphisms rs2234693 and rs9340799 in ESR1 have been largely studied. The evidence linking these polymorphisms and its haplotype to bone mineral density (28,46). Also they were associated with postmenopausal osteoporosis (28,43).…”

Section: Discussionmentioning

confidence: 99%

“…The evidence linking these polymorphisms and its haplotype to bone mineral density (28,46). Also they were associated with postmenopausal osteoporosis (28,43). According to Rivadeneira et al (47), genetic polymorphisms in ESR2 alone and in interaction with ESR1 can also influence the risk of bone fracture in postmenopausal women.…”

Section: Discussionmentioning

confidence: 99%

“…The genetic polymorphisms in ESR1 (rs2234693 and rs9340799), ESR2 (rs1256049 and rs4986938) and VDR (rs739837 and rs2228570) genes were selected based on their function in bone biology (28)(29)(30) and in their minor allele frequencies, that should be higher than 10%.…”

Section: Mirna and Polymorphisms Selectionmentioning

confidence: 99%

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Association between Estrogen, Vitamin D and Microrna17 Gene Polymorphisms and Periapical Lesions

et al. 2020

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This study evaluated the association between polymorphisms in genes encoding estrogen receptors 1 (ESR1) and 2 (ESR2), vitamin D receptor (VDR) and in microRNA17 (which binds to ESR1 and VDR) with persistent apical periodontitis (PAP) after the endodontic treatment. We included 162 patients who completed endodontic treatment at least one year ago and presented apical periodontitis at the beginning of the root canal therapy. Clinical and radiographic exams were performed to evaluate the presence of PAP or healthy periradicular tissues (healed). Saliva samples were collected as a genomic DNA. The genotyping of ESR1 (rs2234693 and rs9340799), ESR2 (rs1256049 and rs4986938), VDR (rs739837 and rs2228570) and miRNA17 (rs4284505) were performed by real-time PCR. Chi-square test was used to the distribution of genotype and allele frequencies. Haplotype analysis was also performed. Eighty-nine patients were included in the “healed” group and 73 in the “PAP” group. No association was found between the allelic and genotypic polymorphisms studied and PAP (p>0.05). Haplotype analysis also did not demonstrated an association (p>0.05). In conclusion, the genetic polymorphisms in ESR1, ESR2, VDR and miRNA17 are not associated with PAP.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Mirna and Polymorphisms Selectionmentioning

confidence: 99%

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Association between Estrogen, Vitamin D and Microrna17 Gene Polymorphisms and Periapical Lesions

et al. 2020

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“…Mondockova et al had found that rs9340799 polymorphism may contribute to decreased BMD in postmenopausal women in southern Slovakia [14]. Nevertheless, Wang et al had showed that rs2234693 polymorphism but not rs9340799 was associated with PMO [21].…”

Section: Discussionmentioning

confidence: 99%

Association of ESR1 polymorphism rs2234693 and rs9340799 with Postmenopausal osteoporosis in a Chinese Population

Shu

et al. 2020

Preprint

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Background Postmenopausal osteoporosis (PMO) is the most common type of primary osteoporosis. ESR1 polymorphism rs2234693 and rs9340799 has been widely studied as a candidate gene associated with PMO, however, the findings were inconclusive. The present study aims to explore the relationship of ESR1 polymorphism rs2234693 and rs9340799 with PMO risk in a Chinese Han population. Methods A total of 230 unrelated PMO patients and 150 control were recruited. DNA of all participants was extracted from the peripheral blood samples and genotyped by Mass Array method. A meta-analysis of case control studies was also conducted to further elucidate the relationship of polymorphism with PMO. Results Our results revealed that there were no associations of the rs2234693 with PMO. However,GG genotype of rs9340799 was associated with a higher risk of PMO (OR=1.51, 95%CI:1.08-4.34, p=0.03), even adjusting for risk factors (OR=1.83, 95%CI: 1.12-5.04, p=0.04). Logistic regression analysis showed the dominant model was associated with a higher risk of PMO (OR = 2.07, 95%CI: 1.02-5.16, p=0.02) after correcting the risk factors (OR=2.14, 95%CI:1.12-5.64, p=0.04); In addition, the Meta-analysis results revealed that both two polymorphisms were not associated with PMO. Conclusion In conclusion,ESR1 polymorphism rs9340799 was associated with PMO, However, well designed study with larger sample sizes, is required to further elucidate these association.

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Current knowledge of bone-derived factor osteocalcin: its role in the management and treatment of diabetes mellitus, osteoporosis, osteopetrosis and inflammatory joint diseases

Martiniakova,

Biro,

Kovacova

et al. 2024

J Mol Med

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Osteocalcin (OC) is the most abundant non-collagenous and osteoblast-secreted protein in bone. It consists of two forms such as carboxylated OC (cOC) and undercarboxylated OC (ucOC). While cOC promotes bone mineralization and increases bone strength, ucOC is regarded an endocrinologically active form that may have several functions in multiple end organs and tissues. Total OC (tOC) includes both of these forms (cOC and ucOC) and is considered a marker of bone turnover in clinical settings. Most of the data on OC is limited to preclinical studies and therefore may not accurately reflect the situation in clinical conditions. For the stated reason, the aim of this review was not only to summarize current knowledge of all forms of OC and characterize its role in diabetes mellitus, osteoporosis, osteopetrosis, inflammatory joint diseases, but also to provide new interpretations of its involvement in the management and treatment of aforementioned diseases. In this context, special emphasis was placed on available clinical trials. Significantly lower levels of tOC and ucOC could be associated with the risk of type 2 diabetes mellitus. On the contrary, tOC level does not seem to be a good indicator of high bone turnover status in postmenopausal osteoporosis, osteoarthritis and rheumatoid arthritis. The associations between several pharmacological drugs used to treat all disorders mentioned above and OC levels have also been provided. From this perspective, OC may serve as a medium through which certain medications can influence glucose metabolism, body weight, adiponectin secretion, and synovial inflammation.

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The estrogen receptor 1 gene affects bone mineral density and osteoporosis treatment efficiency in Slovak postmenopausal women

Cited by 30 publications

References 47 publications

Association between Estrogen, Vitamin D and Microrna17 Gene Polymorphisms and Periapical Lesions

Association between Estrogen, Vitamin D and Microrna17 Gene Polymorphisms and Periapical Lesions

Association of ESR1 polymorphism rs2234693 and rs9340799 with Postmenopausal osteoporosis in a Chinese Population

Current knowledge of bone-derived factor osteocalcin: its role in the management and treatment of diabetes mellitus, osteoporosis, osteopetrosis and inflammatory joint diseases

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