The Evolving Scenario of Copper and Fatty Liver

Medici, Valentina

doi:10.1089/met.2013.1501

Cited by 11 publications

(14 citation statements)

References 19 publications

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“…Iron deficiency increases the absorption of copper, copper deficiency reduces iron absorption, while hepatic copper varies inversely with iron status [27][28][29]. It has been argued that iron overload causes a higher demand for copper in the diet [30].…”

Section: Before Bloodlettingsmentioning

confidence: 99%

Bloodletting therapy in hemochromatosis: Does it affect trace element homeostasis?

Bolann

Distante

Mørkrid

et al. 2015

Journal of Trace Elements in Medicine and Biology

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Section: Before Bloodlettingsmentioning

confidence: 99%

Bloodletting therapy in hemochromatosis: Does it affect trace element homeostasis?

Bolann

Distante

Mørkrid

et al. 2015

Journal of Trace Elements in Medicine and Biology

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“…Homeostatic regulation of intracellular copper is normally tightly controlled, but deregulated copper levels are found in numerous metabolic diseases (e.g. NAFLD, obesity, diabetes, and dyslipidemia), characterized by an altered modulation of the subcellular biometal homeostasis …”

Section: Introductionmentioning

confidence: 99%

Prediction of carotid intima–media thickness in obese patients with low prevalence of comorbidities by serum copper bioavailability

Tarantino

Porcu

Arciello

et al. 2018

J of Gastro and Hepatol

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“…As the liver is the main organ of biotransformation, in which a significant amount of cellular enzyme systems is actively involved, the normal activity of the latter requires entry of the optimal amount of essential trace elements into the organism. Micronutrient deficiencies in the ration lead to a disruption of the functions of the body's enzyme systems [18].…”

Section: Introductionmentioning

confidence: 99%

Morphofunctional Characteristics and Elemental Composition of Rat Liver Under Different Nutrient Provision

E.A.¹

2016

Geomate

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ABSTRACT:The article presents research of structural and functional changes in the liver in the conditions of modeling of micronutrient deficiencies in the organism of experimental animals with subsequent inclusion of complex minerals into their food ration. The object of the study was the liver of rats «Wistar». The elemental composition of biological substrates has been studied using atomic emission and mass spectrometry (ICP-AES and ICP-MS) in the test laboratory ANO «Center for Biotic Medicine». It has been established that the addition of selenium to the ration increases the concentration of this element in the liver by 15,0% (p≤0,05) against the background of lowering nickel by 50,0% (p≤0,05) in the experimental group I relative to control. When you turn on zinc into the ration, the concentration of it increases by 14,3% (p≤0,05) in the experimental group II relative to the control. Inclusion of iodine in the ration contributed to the increase of the iodine concentration by 4,52% in the experimental group III relative to the control group. Thus, the intake by the animal organism of toxic elements (lead and cadmium salts) leads to a change in the structural elements of the liver, resulting in depletion of hepatocyte in glycogen, or its complete disappearance, in offensive vacuolization and necrosis of hepatocytes and in changes in vessels diameter microvasculature, i.e. structural and functional changes in the liver are identified. Introduction into the ration of complex of essential trace elements (I, Se, Zn) involves an increase in functional activity of the liver.

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The Evolving Scenario of Copper and Fatty Liver

Cited by 11 publications

References 19 publications

Bloodletting therapy in hemochromatosis: Does it affect trace element homeostasis?

Bloodletting therapy in hemochromatosis: Does it affect trace element homeostasis?

Prediction of carotid intima–media thickness in obese patients with low prevalence of comorbidities by serum copper bioavailability

Morphofunctional Characteristics and Elemental Composition of Rat Liver Under Different Nutrient Provision

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