The exploration of quantum dot-molecular beacon based MoS2 fluorescence probing for myeloma-related Mirnas detection

Wang, Jing Jing; Ding, Zhou; Zhang, Le; Han, Caiqin; Yan, Changchun; Amador, Eric; Yuan, Liqin; Wu, Ying; Song, Chunyuan; Liu, Ying; Chen, Wei

doi:10.1016/j.bioactmat.2021.12.036

Cited by 28 publications

(26 citation statements)

References 37 publications

(38 reference statements)

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“…In a study, quantum dot-molecular beacon functionalized MoS2 fluorescent probes were employed for the simultaneous identification of MM-correlated miRNA-155 and miRNA-150 [ 110 ]. The two probes can efficiently find miRNA-155 and miRNA-150 with adequate recovery percentages, with a low detection limit.…”

Section: Liquid Biopsy and Mirnasmentioning

confidence: 99%

Circulating Tumour Cells, Cell Free DNA and Tumour-Educated Platelets as Reliable Prognostic and Management Biomarkers for the Liquid Biopsy in Multiple Myeloma

Allegra

Cancemi

Mirabile

et al. 2022

Cancers

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Liquid biopsy is one of the fastest emerging fields in cancer evaluation. Circulating tumour cells and tumour-originated DNA in plasma have become the new targets for their possible employ in tumour diagnosis, and liquid biopsy can define tumour burden without invasive procedures. Multiple Myeloma, one of the most frequent hematologic tumors, has been the target of therapeutic progresses in the last few years. Bone marrow aspirate is the traditional tool for diagnosis, prognosis, and genetic evaluation in multiple myeloma patients. However, this painful procedure presents a relevant drawback for regular disease examination as it requires an invasive practice. Moreover, new data demonstrated that a sole bone marrow aspirate is incapable of expressing the multifaceted multiple myeloma genetic heterogeneity. In this review, we report the emerging usefulness of the assessment of circulating tumour cells, cell-free DNA, extracellular RNA, cell-free proteins, extracellular vesicles, and tumour-educated platelets to evaluate the changing mutational profile of multiple myeloma, as early markers of disease, reliable predictors of prognosis, and as useful tools to perform less invasive monitoring in multiple myeloma.

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Section: Liquid Biopsy and Mirnasmentioning

confidence: 99%

Circulating Tumour Cells, Cell Free DNA and Tumour-Educated Platelets as Reliable Prognostic and Management Biomarkers for the Liquid Biopsy in Multiple Myeloma

Allegra

Cancemi

Mirabile

et al. 2022

Cancers

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“…QDs have attracted increasing attention from more and more researchers due to their advantages, such as tunable emission wavelength, luminescent color diversity, high uorescence quantum e ciency, narrow emission bands, and less susceptibility to spectral overlap (Li et uorescence in two emission bands with the control of the quantum dots size of a shell-core structure probe, and achieved the binary detection of multiple myeloma (MM)-associated miRNA-155 and miRNA-150 (Wang et al 2022). The position of the emission peak of quantum dots can generally be modulated by doping elements and size, and the method is simple and easy to implement as well as widely used.…”

Section: Introductionmentioning

confidence: 99%

Perovskite quantum dots modulating upconversion nanomaterials for cancer early detections

Rao

Wang

et al. 2023

Preprint

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The accurate diagnosis and treatment of cancer cell lesions need a high standard of detection technology. Fluorescent probes to perform cancer biomarker detection have become a popular research issue. However, fluorescent probes still face enormous challenges of complex design and difficult detection. In this work, we propose a novel composite material UCNP@SiO2+QDs based on the combination of rare earth upconversion (UCNP) and perovskite quantum dots (QDs) and design a new fluorescent probe MB-UCNP@SiO2+QDs with molecular beacon (MB) as the carrier, that can be excited by near-infrared light, emitted in the visible wavelength, specifically identified and highly sensitive. Under the excitation of 980 nm near-infrared light, the UCNP and QDs in the composite produced the maximum efficiency of energy transfer through fluorescence resonance, and the multi-emission light of UCNP synergistically excited the re-emission of QDs, and the energy transfer efficiency is 70.6%. By changing the doping ratio of QDs halogen elements in UCNP@SiO2+QDs, it is possible to modulate the precise luminescence of UCNP@SiO2+QDs in the entire wavelength range of visible light at different positions. The novel fluorescent probe is obtained using UCNP@SiO2+QDs and Black Hole Quencher-1 (BHQ1) quenching groups linked to the two respective sides of MB, selecting as the target of detection the myeloma cancer biomarker miRNA-155, a difficult diagnostic and complex developmental type, and have achieved specific recognition and low concentration of miRNA-155 and a detection limit of 73.5 pM. This fluorescent probe design can provide new ideas for the early diagnosis and treatment of cancer, tumors, and cardiovascular diseases.

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“…Among the different advanced functional materials being explored for the development of electrochemical biosensors, molybdenum disulfide (MoS 2 ) and metal–organic frameworks (MOFs) have established their unique reputations. 10 The nanoforms of MoS 2 offer the advantages of both direct and indirect band gap properties, and they have been advocated highly useful in electrochemical and optical sensors. 11 In particular, the MoS 2 QDs are easier to synthesize with better control on the shape and morphology.…”

Section: Introductionmentioning

confidence: 99%

Selective and Sensitive Electrochemical Sensor for Aflatoxin M1 with a Molybdenum Disulfide Quantum Dot/Metal–Organic Framework Nanocomposite

et al. 2022

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Aflatoxins are the hepatotoxic secondary metabolites which are highly carcinogenic and known to cause several adverse effects on human health. The present study reports a simple, sensitive, and novel electrochemical sensor for aflatoxin M1 (AFM1). The sensor has been fabricated by modifying the screen-printed carbon electrodes with a functional nanocomposite of molybdenum disulfide (MoS 2 ) quantum dots (QDs) and a zirconium-based metal–organic framework (MOF), that is, UiO-66-NH 2 . The MoS 2 /UiO-66-modified electrodes were decorated with the AFM1-specific monoclonal antibodies and then investigated for the electrochemical detection of AFM1. Based on the electrochemical impedance spectroscopy analysis, it was possible to detect AFM1 in the concentration range of 0.2–10 ng mL –1 with a limit of detection of 0.06 ng mL –1 . The realization of an excellent sensing performance can be attributed to the electroactivity of MoS 2 QDs and the large surface to volume area achieved by the addition of the MOF. The presence of UiO-66-NH 2 is also useful to attain readily available amine functionality for the robust interfacing of antibodies. The performance of the developed sensor has also been validated by detecting AFM1 in the spiked milk samples.

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The exploration of quantum dot-molecular beacon based MoS2 fluorescence probing for myeloma-related Mirnas detection

Cited by 28 publications

References 37 publications

Circulating Tumour Cells, Cell Free DNA and Tumour-Educated Platelets as Reliable Prognostic and Management Biomarkers for the Liquid Biopsy in Multiple Myeloma

Circulating Tumour Cells, Cell Free DNA and Tumour-Educated Platelets as Reliable Prognostic and Management Biomarkers for the Liquid Biopsy in Multiple Myeloma

Perovskite quantum dots modulating upconversion nanomaterials for cancer early detections

Selective and Sensitive Electrochemical Sensor for Aflatoxin M1 with a Molybdenum Disulfide Quantum Dot/Metal–Organic Framework Nanocomposite

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