The expression level of COX7C associates with venous thromboembolism in colon cancer patients

Wu, Biyu; Chen, Shu-Rong; Zhuang, Lihong; Zeng, Jingyang

doi:10.1007/s10238-020-00644-1

Cited by 7 publications

(6 citation statements)

References 20 publications

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“…Likewise, the gene was upregulated in colon cancer patients after receiving five-fluorouracil treatment suggesting a possible role of this gene in patients response to chemotherapy [24]. It was also recently reported that COX7C is implicated in development of venous thromboembolism in patients with colon cancer [25]. This is in concordance with another study, which reported that COX7C is associated with venous thromboembolism via its ability to inhibit miR-200a-5p [26].…”

Section: Discussionsupporting

confidence: 82%

Gene expression profile and presentation of novel gene variants of COX7B and COX7C in a cohort of patients with chronic myeloid leukemia

El‐Masry

2023

ELECTRON J GEN MED

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Chronic myeloid leukemia (CML) is a common blood malignancy awaiting decisive cure. Understanding the genomic nature of the disease could help to improve treatment strategies and introduce novel therapeutic targets. The purpose of this study was to sequence the entire transcriptome of a cohort of CML patients to understand differences in gene expression profiles and gene variants compared to healthy controls. RNA was extracted from 10 CML and four healthy control subjects and sequenced by the DNBSEQ platform. Differential gene expression was evaluated and confirmed by the q-RT-PCR technique. Gene variants were also analyzed. The results showed that COX7B and COX7C were upregulated in CML patients than in controls; this was confirmed by quantitative PCR. In addition, novel single nucleotide and insertion/deletion variants were also found in both genes. In conclusion, the results of this study recommend further exploration of COX7B and COX7C and their novel variants in myeloid leukemogenesis.

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Section: Discussionsupporting

confidence: 82%

Gene expression profile and presentation of novel gene variants of COX7B and COX7C in a cohort of patients with chronic myeloid leukemia

El‐Masry

2023

ELECTRON J GEN MED

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“…34 Second, COX7C has been proven to be correlated with VTE in colon cancer patients. 35 These data might suggest that upregulation of COX7C could accelerate VTE progression. In conclusion, the present study identified the protective role of miR-200a-5p against VTE in which overexpression suppressed COX7C expression and consequently inhibited thrombosis.…”

Section: Discussionmentioning

confidence: 95%

Integrated Bioinformatics Analysis Identifies microRNA-200a-5p as a New Plasma Marker in Patients with Venous Thromboembolism

Lan

Tong

et al. 2022

Annals of Vascular Surgery

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“…COX7C is a subunit of cytochrome c oxidase and is responsible for electron transfer from cytochrome c to oxygen ( Hofmann et al, 1998 ). In addition, studies have shown that COX7C is a key regulator in the physiological processes of numerous diseases, where upregulation of this gene is associated with the development of many cancer tumors ( Wang et al, 2017 ; Wang et al, 2022 ) and its downregulation is a feature of many chronic kidney diseases ( Zaza et al, 2013 ; Wu et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Blood transcriptome reveals immune and metabolic-related genes involved in growth of pasteurized colostrum-fed calves

Li²,

Yang³

et al. 2023

Front. Genet.

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The quality of colostrum is a key factor contributing to healthy calf growth, and pasteurization of colostrum can effectively reduce the counts of pathogenic microorganisms present in the colostrum. Physiological changes in calves fed with pasteurized colostrum have been well characterized, but little is known about the underlying molecular mechanisms. In this study, key genes and functional pathways through which pasteurized colostrum affects calf growth were identified through whole blood RNA sequencing. Our results showed that calves in the pasteurized group (n = 16) had higher body height and daily weight gain than those in the unpasteurized group (n = 16) in all months tested. Importantly, significant differences in body height were observed at 3 and 4 months of age (p < 0.05), and in daily weight gain at 2, 3, and 6 months of age (p < 0.05) between the two groups. Based on whole blood transcriptome data from 6-months old calves, 630 differentially expressed genes (DEGs), of which 235 were upregulated and 395 downregulated, were identified in the pasteurized compared to the unpasteurized colostrum groups. Most of the DEGs have functions in the immune response (e.g., CCL3, CXCL3, and IL1A) and metabolism (e.g., PTX3 and EXTL1). Protein-protein interaction analyses of DEGs revealed three key subnetworks and fifteen core genes, including UBA52 and RPS28, that have roles in protein synthesis, oxidative phosphorylation, and inflammatory responses. Twelve co-expression modules were identified through weighted gene co-expression network analysis. Among them, 17 genes in the two modules that significantly associated with pasteurization were mainly involved in the tricarboxylic acid cycle, NF-kappa B signaling, and NOD-like receptor signaling pathways. Finally, DEGs that underwent alternative splicing in calves fed pasteurized colostrum have roles in the immune response (SLCO4A1, AKR1C4, and MED13L), indicative of potential roles in immune regulation. Results from multiple analytical methods used suggest that differences in calf growth between the pasteurized and unpasteurized groups may be due to differential immune activity. Our data provide new insights into the impact of pasteurization on calf immune and metabolic-related pathways through its effects on gene expression.

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The expression level of COX7C associates with venous thromboembolism in colon cancer patients

Cited by 7 publications

References 20 publications

Gene expression profile and presentation of novel gene variants of <i>COX7B</i> and <i>COX7C</i> in a cohort of patients with chronic myeloid leukemia

Gene expression profile and presentation of novel gene variants of <i>COX7B</i> and <i>COX7C</i> in a cohort of patients with chronic myeloid leukemia

Integrated Bioinformatics Analysis Identifies microRNA-200a-5p as a New Plasma Marker in Patients with Venous Thromboembolism

Blood transcriptome reveals immune and metabolic-related genes involved in growth of pasteurized colostrum-fed calves

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