The expression of ABH and Y blood group antigens in benign and malignant breast tissue: The preservation of the H and Y antigens in malignant epithelium

Antibody BNH9 detects red blood cell-related antigens on anaplastic large cell (CD30+) lymphomas

“…Similarly, the reactivity of many normal epithelial cells as well as many carcinoma cells of diverse origin, is in agreement with previous studies on the tissue distribution of H and Y antigens (Feizi, 1985;Coon & Weinstein, 1986;Vowden et al, 1986). Lymphocytes are known to express ABH and Lewis determinants under the control of the Se and Le genes (Dunstan, 1986;Oriol et al, 1980).…”

“…These antigens, first described on erythrocytes, have been demonstrated in many extraerythroid normal tissues (Coon & Weinstein, 1986) and in a variety of human tumours (Feizi, 1985;Lloyd, 1987). Among these blood group antigens, H and Y determinants have been the subject of a number of investigations as to their distribution in normal and malignant epithelial cells (Szulman, 1962;Coon & Weinstein, 1986;Kimmel et al, 1986;Vowden et al, 1986;Schoetag et al, 1987;Le Pendu et al, 1989;Orntoft et al, 1989). H and Y determinant expression may be related to invasive potential of urothelial carcinomas (Coon & Weinstein, 1986;Orntoft et al, 1989).…”

Inhibition of MT-450 rat mammary tumour growth by antibodies recognising subtypes of blood group antigen B

“…Conversely to our ®ndings in the rat MT-W9 model, several studies show that loss of expression of A and B antigens occurs during human breast tumour progression, although inappropriate A and B antigen in human mammary carcinomas has been reported in O individuals (Strauchen et al, 1980;Lee et al, 1985;Vowden et al, 1986;Ura et al, 1992). The studies on ABH expression in human mammary tumours re¯ect the fact that we found very few rat tumour cells which express M-N#1 (Table 1), suggesting that the upregulation of M-N#1 in the MT-W9 model may be paralleled in only a small subset of human tumours.…”

Association of ABO Blood Group and Risk of Breast Cancer

“…Alterations in ABO antigen expression on the surface of malignant cells have been seen for a variety of tumor types, including breast cancer [40,41]. The expression of blood group A has been reported to increase resistance to apoptosis and facilitate escape from immune control in rat colon carcinoma cells [42].…”