Abstract. We investigate different approaches for the computation of the action of the weighted geometric mean of two large-scale positive definite matrices on a vector. We derive several algorithms, based on numerical quadrature and the Krylov subspace, and compare them in terms of convergence speed and execution time. By exploiting an algebraic relation between the weighted geometric mean and its inverse, we show how these methods can be used for the solution of large linear system whose coefficient matrix is a weighted geometric mean. We derive two novel algorithms, based on Gauss-Jacobi quadrature, and tailor an existing technique based on contour integration. On the other hand, we adapt several existing Krylov subspace techniques to the computation of the weighted geometric mean. According to our experiments, both classes of algorithms perform well on some problems but there is no clear winner, while some problem-dependent recommendations are provided.