The extracellular polysaccharide produced from sucrose by a cariogenic streptococcus

Wood, Jeanie M.; Critchley, Peter

doi:10.1016/0003-9969(66)90204-4

Cited by 83 publications

(29 citation statements)

References 9 publications

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“…3 (4) Several typical oral bacteria have been shown to produce dextran and levan in culture media containing sucrose. [4][5][6][7] At the present time, little else is known of either the structure or the function of these polysaccharides as they actually occur in the plaque matrix. It is known that many species of bacteria produce both the foregoing and several other polysaccharides from a variety of the more common sugars under many experimental conditions.8 The composition and structure of these polysaccharides are both variable and complicated8 and are a function of several factors the value and control of which cannot yet be appreciated within the dental plaque as it exists in vivo.…”

mentioning

confidence: 99%

Biochemical Studies on the Formation and Composition of Dental Plaque in Relation to Dental Caries: Extracellular Polysaccharides

1969

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Biochemical Studies on the Formation and Composition of Dental Plaque in Relation to Dental Caries: Extracellular Polysaccharides

1969

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“…There is evidence that the establishment of Strep, sanguis and Strep, mu tans in the oral cavity depends on the presence of teeth [Carlsson et al, 1969[Carlsson et al, , 1970C ornick and Bow en , 1971]. The ability of streptococci to colonize the teeth has been ascribed to species-specific factors such as ad herence and dextran production [Wood and Critchley, 1966;G ibbons et al, 1966;van H oute et al, 1971], to the compatibility with the resi dent microflora [Keyes and F itzgerald, 1962;K rasse et al, 1967;J or dan et al, 1972] and to the chemical characteristics of carbohydrates and their concentrations in the diet [Krasse, 1965;G uggenheim et al, 1966;Bowen and C ornick, 1967].…”

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Effect of Actinomyces viscosus on the Establishment and Symbiosis of Streptococcus mutans and Streptococcus sanguis in SPF Rats on Different Sucrose Diets

et al. 1975

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The effects of Actinomyces viscosus on the establishment and symbiosis of Streptococcus mutans and Streptococcus sanguis and of the sucrose concentration of the diet in relation to caries in rats were investigated. SPF-Osborne Mendel rats were erythromycin-treated and inoculated with Strep. mutans OMZ176E and Strep. sanguis Ny101E. In a second experiment SPF rats were superinoculated with A. viscosus Ny1, Strep. mutans OMZ176E and Strep. sanguis Ny101E. During the experiments the microbial composition of the plaque was followed. The proportion of the inoculated strains in the cultivated plaque flora was relatively low, being 50% in the erythromycin-treated rats and 85% in the SPF rats. A resistance against colonization of Strep. mutans OMZ176E was found in the rats pre-inoculated with A. viscosus Ny1 and Strep. sanguis Ny101E. No effect of the sucrose concentration in the diet on the bacterial composition and on the amount of plaque was observed. No positive correlation was found between the amount of plaque and the incidence of caries lesions. A significant positive correlation between the sucrose content of the diet and the incidence of fissure and smooth surface lesions was found. A predominant demineralization of smooth surface and distal fissures was observed in the erythromycin-treated rats that were inoculated with Strep, mutans OMZ176E. The results suggest that the concentration of sucrose in the diet and the microbial composition, rather than the gross amount of plaque, are the important factors in the caries process in rats.

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“…S. mutans synthesizes extracellular polysaccharides from sucrose. This together with the biologically relatively inert and insoluble glucans induces an increase in adhesion and bacterial aggregation (8,13), thus contributing to plaque formation on teeth.…”

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Interspecies Transformation of Streptomycin Resistance in Oral Streptococci

Davidson

Blevins

Feary

1976

Antimicrob Agents Chemother

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Donor deoxyribonucleic acid extracted from streptomycin-resistant (Str R ) mutant derivatives of a variety of strains of Streptococcus mutans, S. salivarius , and S. sanguis was used to transform streptomycin resistance into competent S. sanguis strain Challis. Transfer of genetic markers for sorbitol and mannitol fermentation and for extracellular polysaccharide as demonstrated by colonial morphology was not detected in this study. Reciprocal transformation between strain Challis and other oral streptococci could not be demonstrated. Transformation frequencies for Str R were relatively efficient among S. sanguis strains, with lower but significant frequencies demonstrated with strain Challis and donor deoxyribonucleic acid derived from other oral streptococci.

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The extracellular polysaccharide produced from sucrose by a cariogenic streptococcus

Cited by 83 publications

References 9 publications

Biochemical Studies on the Formation and Composition of Dental Plaque in Relation to Dental Caries: Extracellular Polysaccharides

Biochemical Studies on the Formation and Composition of Dental Plaque in Relation to Dental Caries: Extracellular Polysaccharides

Effect of Actinomyces viscosus on the Establishment and Symbiosis of Streptococcus mutans and Streptococcus sanguis in SPF Rats on Different Sucrose Diets

Interspecies Transformation of Streptomycin Resistance in Oral Streptococci

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