The fate of certain organic acids and amides in the rabbit

Bray, H. G.; Ryman, Brenda E.; Thorpe, W. V.

doi:10.1042/bj0410212

Cited by 66 publications

(69 citation statements)

References 11 publications

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“…Hydroxylation of the hydroxybenzoic acids and amides Accounts of investigations of these compounds by ordinary chemical methods have been published (Bray et al 1947;, but although the main metabolic pathways of these six compounds were traced some details, relating to the hydroxylation products, could not be satisfactorily elucidated. The hydroxylation products which have since been detected in ether extracts of the urines by means ofpaper chromatograms are shown in Table 3.…”

Section: Resultsmentioning

confidence: 99%

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The fate of certain organic acids and amides in the rabbit. 10. The application of paper chromatography to metabolic studies of hydroxybenzoic acids and amides

Bray

Thorpe

White

1950

Biochemical Journal

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236

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Section: Resultsmentioning

confidence: 99%

“…weremaintained throughout the investigation on the diet of rabbit pellets and water previously described (Bray, Ryman & Thorpe, 1947). The cresols were administered by stomach tube as solutions in NaHCO3.…”

Section: Metabolism Of Derivatives Of Toluenementioning

confidence: 99%

The fate of certain organic acids and amides in the rabbit. 10. The application of paper chromatography to metabolic studies of hydroxybenzoic acids and amides

Bray

Thorpe

White

1950

Biochemical Journal

Self Cite

236

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“…204. ) Diet and dosage The rabbits used, does weighing 2-3 kg., were maintained throughout on the standard diet of rabbit pellets previously described (Bray, Ryman & Thorpe, 1947). The nitriles were administered by stomach tube as emulsions in warm water and the acids as solutions of their Na salts.…”

Section: Methodsmentioning

confidence: 99%

“…Ether-soluble acid, ester and ether type glucuronides and ethereal sulphate were estimated as previously described (see Bray et al 1947;Bray, Thorpe & White, 1950b). The paperchromatographic technique was essentially that described in an earlier paper (Bray, Thorpe & White, 1950 a).…”

Section: Methods Of Analysismentioning

confidence: 99%

Metabolism of derivatives of toluene. 6. Tolunitriles, benzonitrile and some related compounds

Bray

Hybs

Thorpe

1951

Biochemical Journal

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“…Ammon ' ia large amounts from zein without rupture of peptide bonds. Deami nation of various amides has been studied by Bray et al (217).…”

Section: Experiments By Flock and Bollmanmentioning

confidence: 99%

Nonoxidative Nonproteolytic Enzymes

Myrbäck¹

1949

Annu. Rev. Biochem.

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It has been, more or less, a tacit assumption that enzymes constitute only a small part of the protein of the living cell.Virtanen has pointed out that from our present knowledge of the quantities of enzymes it seems justifiable to conclude that in microorganisms practically all protein is enzyme protein. There fore, the formation of an adaptive enzyme should correspond to a decrease in some other enzyme or enzymes, presumably of a related type. Lowering of the protein content of the cell by starvation should decrease primarily the amounts of adaptable (dispensable) enzymes, whereas the indispensable (constitutive) enzymes should maintain their activity. Virtanen & De Ley (1) have determined saccharase in E. coli which is, in this case, an adaptive enzyme, and catalase, a typically constitutive enzyme. By nitrogen starvation the protein content of the cells could be materially decreased. The saccharase content fell rapidly but catalase activity was only slightly affected. Investigations by Bucher & Kaspers (2) on the photochemical splitting of carbon monoxide hemoglobin may throw light on the action of the protein carrier on the prosthetic groups of enzymes. Not only radiation absorbed by the hemin splits off carbon monoxide, but also radiation absorbed by the protein. In the photo inactivation of urease the effect is the same, if the quanta are absorbed by a few tyrosine or tryptophane residues or by all amino acids. It is suggested that transmission of absorbed activation energy may be one of the causes of the chemical activation of prosthetic groups by the carriers. Attention is called to a paper by Veldstra (3) on the interaction of "ergones" and substrates. Rothen's experiments on "enzyme action at a distance" were mentioned in Vol. XVII of this Review. New experiments (4) have been published which are thought to exclude the possibility of diffusion of the enzyme through the protecting layers. Mettler, however, points out (5) that the antigen films are not of constant 1 This review covers approximately the period from December, 1947 to De cember, 1948. 59 Annu. Rev. Biochem. 1949.18:59-86. Downloaded from www.annualreviews.org Access provided by Technische Universiteit Eindhoven on 02/02/15. For personal use only. Quick links to online content Further ANNUAL REVIEWS

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The fate of certain organic acids and amides in the rabbit

Cited by 66 publications

References 11 publications

The fate of certain organic acids and amides in the rabbit. 10. The application of paper chromatography to metabolic studies of hydroxybenzoic acids and amides

The fate of certain organic acids and amides in the rabbit. 10. The application of paper chromatography to metabolic studies of hydroxybenzoic acids and amides

Metabolism of derivatives of toluene. 6. Tolunitriles, benzonitrile and some related compounds

Nonoxidative Nonproteolytic Enzymes

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