The fate of memory: Reconsolidation and the case of Prediction Error

Fernández, Rodrigo S.; Boccia, Mariano Martín; Pedreira, Marı́a Eugenia

doi:10.1016/j.neubiorev.2016.06.004

Cited by 158 publications

(128 citation statements)

References 244 publications

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“…As a result, memory may not have been destabilized and there was no opportunity for propranolol to exert its fear-reducing effect. However, it should be noted that this argument, stating that the failure of propranolol possibly implies the absence of PE, is somehow circular, as it is based on previous evidence indicating that PE is required for memory destabilization and, in turn, for propranolol to interfere with the memory trace (Sevenster et al, 2013; Exton-McGuinness et al, 2015; Fernández et al, 2016). In addition, this explanation is purely hypothetical, since there was no independent measure of PE in this experiment (see Limitations).…”

Section: Discussionmentioning

confidence: 99%

In Search for Boundary Conditions of Reconsolidation: A Failure of Fear Memory Interference

Schroyens

Beckers

Kindt

2017

Front. Behav. Neurosci.

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The presentation of a fear memory cue can result in mere memory retrieval, destabilization of the reactivated memory trace, or the formation of an extinction memory. The interaction between the degree of novelty during reactivation and previous learning conditions is thought to determine the outcome of a reactivation session. This study aimed to evaluate whether contextual novelty can prevent cue-induced destabilization and disruption of a fear memory acquired by non-asymptotic learning. To this end, fear memory was reactivated in a novel context or in the original context of learning, and fear memory reactivation was followed by the administration of propranolol, an amnestic drug. Remarkably, fear memory was not impaired by post-reactivation propranolol administration or extinction training under the usual conditions used in our lab, irrespective of the reactivation context. These unexpected findings are discussed in the light of our current experimental parameters and alleged boundary conditions on memory destabilization.

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Section: Discussionmentioning

confidence: 99%

In Search for Boundary Conditions of Reconsolidation: A Failure of Fear Memory Interference

Schroyens

Beckers

Kindt

2017

Front. Behav. Neurosci.

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“…The extinction during the UCS-induced reconsolidation of all original memories could erase all UCS-associated memories. The weaker UCS rather than the original UCS could trigger the reconsolidation that could be modified by extinction, suggesting that a negative prediction error was required in the 'UCS-retrieval extinction' (Fernandez et al, 2016). Another explanation is that the original memories were updated rather than disrupted by the 'UCS-retrieval extinction'.…”

Section: 'Ucs-retrieval Extinction' On Drug Reward Memorymentioning

confidence: 99%

Modulating reconsolidation and extinction to regulate drug reward memory

Liu

Tian

2018

Eur J of Neuroscience

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Drug addiction is an aberrant memory that shares the same memory processes as other memories. Brief exposure to drug-associated cues could result in reconsolidation, a hypothetical process during which original memory could be updated. In contrast, longer exposure times to drug-associated cues could trigger extinction, a process that decreases the conditioned responding. In this review, we discuss the pharmacological and non-pharmacological manipulations on the reconsolidation and extinction that could be used to interfere with drug reward memories. Pharmacological agents such as β-adrenergic receptor antagonist propranolol can interfere with reconsolidation to disrupt drug reward memory. Pharmacological agents such as the NMDA receptor glycine site agonists d-cycloserine and d-serine can facilitate extinction and then attenuate the expression of drug reward memory. Besides pharmacological interventions, drug-free behavioral approaches by utilizing the reconsolidation and extinction, such as 'post-retrieval extinction' and 'UCS-retrieval extinction', are also effective to erase or inhibit the recall of drug reward memory. Taken together, pharmacological modulation and non-pharmacological modulation of reconsolidation and extinction are promising approaches to regulate drug reward memory and prevent relapse.

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“…We hypothesized that retrieval procedures that produced prediction errors (CS-, US-, or shock-associated context-alone reminders; Rescorla & Wagner, 1972) would be more effective than a CS+US trial in promoting reconsolidation update and in preventing fear renewal (provided animals were sufficiently extinguished). This hypothesis is based on work by Sevenster and colleagues (2012, 2013, 2014), which highlight the importance of prediction error in engaging reconsolidation (Fernández et al, 2016). Accordingly, rats were conditioned and underwent extinction 1 h after brief or single exposure to the CS, US, a CS+US trial, or the conditioning context; another group of rats did not receive any retrieval procedure to serve as a control.…”

Section: Introductionmentioning

confidence: 99%

Extinction after fear memory reactivation fails to eliminate renewal in rats

Goode

Holloway-Erickson

2017

Neurobiology of Learning and Memory

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Retrieving fear memories just prior to extinction has been reported to effectively erase fear memories and prevent fear relapse. The current study examined whether the type of retrieval procedure influences the ability of extinction to impair fear renewal, a form of relapse in which responding to a conditional stimulus (CS) returns outside of the extinction context. Rats first underwent Pavlovian fear conditioning with an auditory CS and footshock unconditional stimulus (US); freezing behavior served as the index of conditioned fear. Twenty-four hours later, the rats underwent a retrieval-extinction procedure. Specifically, 1 h prior to extinction (45 CS-alone trials; 44 for rats receiving a CS reminder), fear memory was retrieved by either a single exposure to the CS alone, the US alone, a CS paired with the US, or exposure to the conditioning context itself. Over the next few days, conditional freezing to the extinguished CS was tested in the extinction and conditioning context in that order (i.e., an ABBA design). In the extinction context, rats that received a CS+US trial before extinction exhibited higher levels of conditional freezing than animals in all other groups, which did not differ from one another. In the renewal context, all groups showed renewal, and none of the reactivation procedures reduced renewal relative to a control group that did not receive a reactivation procedure prior to extinction. These data suggest retrieval-extinction procedures may have limited efficacy in preventing fear renewal.

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The fate of memory: Reconsolidation and the case of Prediction Error

Cited by 158 publications

References 244 publications

In Search for Boundary Conditions of Reconsolidation: A Failure of Fear Memory Interference

In Search for Boundary Conditions of Reconsolidation: A Failure of Fear Memory Interference

Modulating reconsolidation and extinction to regulate drug reward memory

Extinction after fear memory reactivation fails to eliminate renewal in rats

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