The fatty acids from LPL-mediated processing of triglyceride-rich lipoproteins are taken up rapidly by cardiomyocytes

Correlative light electron ion microscopy reveals in vivo localisation of bedaquiline in Mycobacterium tuberculosis–infected lungs

“…Ion microscopy methods using nanoSIMS represents a good combination of spatial resolution and sensitivity to map drugs that contain elements other than bromine that are low in the biological systems such as platinum [ 16 ], gold [ 17 ], and iodine [ 18 ]. What makes the approach more widely applicable is the nanoSIMS capability to detect stable isotope-labelled molecules with high resolution such as molecules that are labelled with 2 H [ 18 , 19 ], 13 C [ 18 , 20 ], and 15 N [ 21 , 22 ]. All of these stable isotopes can be used to label drugs of interest and mapped using the multiplexed imaging potential of CLEIMiT.…”

Correlative Light Electron Ion Microscopy revealin vivolocalisation of bedaquiline inMycobacterium tuberculosisinfected lungs

“…Ion microscopy methods using nanoSIMS represents a good combination of spatial resolution and sensitivity to map drugs that contain elements other than Bromine that are low in the biological systems such as platinum [16], gold [17] and iodine [18]. What makes the approach more widely applicable is the nanoSIMS capability to detect stable isotope labelled molecules with high-resolution such as molecules that are labelled with 2 H [19,20], 13 C [19,21] and 15 N [22,23]. All of these stable isotopes can be used to label drugs of interest and mapped using the multiplexed imaging potential of CLEIMiT.…”