The fine structure of the rat prostatic complex

Brandes, David; Groth, D.P.

doi:10.1016/0014-4827(61)90072-6

Cited by 30 publications

(9 citation statements)

References 14 publications

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“…Ultrastructural differences between these types of secretory cells may reflect differences in their physiological activity; and this may also result in the observed differences in the amount of secretion within the lumen, and thus the distension of the acini. Brandes and Groth (1961) demonstrated another type of secretory cell in the dorsal prostate of the rat. Here the rough endoplasmic reticulum appeared as a diffuse, relatively poorly defined continuous phase, and the cytoplasm as small isolated profiles within the rough endoplasmic reticulum cisternae.…”

Section: Discussionmentioning

confidence: 97%

Fine structure of the ventral and dorsal lobes of the prostate in the young adult syrian hamster, Mesocricetus auratus

Toma

Buzzell

1988

Am. J. Anat.

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The normal ventral and dorsal prostatic lobes of the young adult Syrian hamster were examined at the light and electron microscopic levels. Each lobe is composed of branched tubular secretory units separated from each other by loose interacinar connective tissue and draining into the urethra. The lumen of each acinus is lined by a simple epithelium composed of columnar secretory cells with occasional small basal cells. The epithelial layer, with the thin underlying lamina propria, forms a mucosa that is often highly folded. The whole acinus is bounded by a thick muscular stroma. In each of the ventral lobes, there are three main ducts, each one formed of tubular branched tributary secretory units. The walls of the secretory acini are moderately folded. Microvilli dominate the lumenal surface of the secretory epithelial cells. The Golgi complex is very extensive and shows dilated cisternae and secretory vesicles and vacuoles of various sizes. Membrane-bounded secretory granules populate the Golgi and apical areas and are released into the acinar lumen by exocytosis. The rough endoplasmic reticulum is dispersed throughout the cytoplasm, except in the region of the Golgi apparatus. In each of the dorsal lobes, there are several main tubular ducts that open into the urethra. Both proximal (ductal) and distal portions of the glandular tree are secretory in nature. Microvilli and cytoplasmic bulges and blebs dominate the lumenal surface of the secretory cells. The cells are also characterized by highly dilated cisternae of rough endoplasmic reticulum. The secretory cells show heterogeneity in the degree of dilation and distribution of rough endoplasmic reticulum, and this heterogeneity may reflect location in the glandular tree.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 97%

Fine structure of the ventral and dorsal lobes of the prostate in the young adult syrian hamster, Mesocricetus auratus

Toma

Buzzell

1988

Am. J. Anat.

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“…Although the lateral lobe is always described together with the dorsal lobe as the ''dorsolateral'' prostate, their epithelial cells are different in their ultrastructure: there are dense secretory granules, microvilli, and rough endoplasmic reticulum with flattened cisternae, but the absence of apical cytoplasmic blebs (structural features of which are not found in the dorsal lobe) indicate that its secretions are different from those of its counterpart [5,7,46]. Two types of lateral prostate differing in their ductal patterns have also been described in the rat [8].…”

Section: Lateral Prostatementioning

confidence: 96%

“…The differential staining of the epithelial cells by Gal/GalNAc-specific lectins (PNA, SBA, HAA, HPA, and SNA) has revealed that the contents of glycoconjugates or glycoconjugate secretory activities of the epithelial cells are heterogeneous in the same acini in the dorsal prostate. Two types of secretory epithelial cells, differing mainly in their dilated cisternae of rough endoplasmic reticulum, were described by Brandes and Groth [5]. However, the glycoconjugates elaborated by these two cell types remain to be determined.…”

Section: Dorsal Prostatementioning

confidence: 98%

“…The paired coagulating glands, originally called the anterior or craniodorsal prostate lobe, lie adjacent to the seminal vesicles, and were given their name as their secretion, containing a transglutaminase, can coagulate the basic clotting proteins from the seminal vesicles [3,4]. The different prostatic lobes are different in their histology [5][6][7], ductal patterns [8], secretions [4,9,10], biochemical parameters [11], and responses to hormones [12] and castration [13]. Lobe-specific carbohydrates and glycoproteins are secreted by different prostatic lobes.…”

Section: Introductionmentioning

confidence: 99%

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Comparative study of glycoconjugates of the rat prostatic lobes by lectin histochemistry

Chan

1999

Prostate

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“…This fluid is essential for the activation and nour-ishment of the sperms. This, together with the frequent occurrence of prostatic cancer and nodular hyperplasia in man [Robbins, 1967;Kirchheim et al, 1974], stimulated extensive studies of these glands and their homologues in other animals [Brandes, 1963;Brandes and Groth, 1961;Dahl, et al, 1973;Flickinger, 1970Flickinger, , 1971Flickinger, , 1974aLoving and Flickinger, 1976;Helminen and Ericsson, 1970, 1972aSchrodt, 1961Schrodt, , 1963,…”

Section: Introductionmentioning

confidence: 99%

Fine Structural and Functional Study of the Prostatic Complex of the Guinea Pig

Wong¹,

Tse²

1981

Cells Tissues Organs

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The fine structure of the prostate gland of the guinea pig was studied by electron microscopy. The lateral lobe was characterized by tall columnar epithelium which formed various degrees of foldings. The epithelial cells had well developed granular endoplasmic reticulum (GER). The cisternae were closely packed and often arranged in concentric configuration in the basal cytoplasm. The apical cytoplasm was characterized by a large Golgi and prominent secretory granules. The luminal border typically contained microvilli. Fusion of the secretory granules with the luminal membrane were observed. The secretion in this lobe is believed to be triggered by a merocrine mechanism. The glandular cells of the dorsal prostate were characterized by well-developed and dilated GER. Most cells had no secretory granules and the luminal surface was endowed with microvilli. It is believed that in these cells the secretion is stored in the cisternae and may be discharged directly into the lumen. A small number of cells in the dorsal prostate showed large dense secretory granules in the apical region. Secretion in this group of cells, as in the cells of the lateral prostate, is believed to be produced by a merocrine mechanism. The coagulating gland on the other hand, had sparser GER and less dilated cisternae. The cells contained no secretory granules and usually had a small Golgi. Apical blebs were commonly found in these cells. Apical blebs have been observed to pinch off from the apical cytoplasm and to release the small sacs of secretory material into the lumen. This is an apocrine mechanism of secretion.

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The fine structure of the rat prostatic complex

Cited by 30 publications

References 14 publications

Fine structure of the ventral and dorsal lobes of the prostate in the young adult syrian hamster, Mesocricetus auratus

Fine structure of the ventral and dorsal lobes of the prostate in the young adult syrian hamster, Mesocricetus auratus

Comparative study of glycoconjugates of the rat prostatic lobes by lectin histochemistry

Fine Structural and Functional Study of the Prostatic Complex of the Guinea Pig

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