The first case of acinic cell carcinoma of the breast within a fibroadenoma: Case report

Limite, Gennaro; Micco, Rosa Di; Esposito, E.; Sollazzo, Viviana; Cervotti, Maria; Pettinato, Guido; Varone, Valeria; Benassai, Giacomo; Monda, Angela; Luglio, Gaetano; Maisto, Vincenzo; Izzo, Gaia; Forestieri, Pietro

doi:10.1016/j.ijsu.2014.05.005

Cited by 8 publications

(3 citation statements)

References 20 publications

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“…A detailed morphologic description was provided in 31 of these cases [1,4,7–25]. Shimao et al [9] reported the only case of breast AcCC to date occurring in a male patient.…”

Section: Resultsmentioning

confidence: 99%

Acinic cell carcinoma of breast: morphologic and immunohistochemical review of a rare breast cancer subtype

et al. 2016

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Summary Acinic cell carcinoma of breast is a rare subtype of triple-negative breast carcinoma and demonstrates extensive morphologic overlap with acinic cell carcinoma of the salivary gland. In this study, we perform a detailed morphologic and immunohistochemical description of 2 cases of this rare entity and undertake a comprehensive review of all reported cases of breast acinic cell carcinoma in the English language literature to date. One-third of reported cases of breast acinic cell carcinoma have been associated with the presence of a ductal carcinoma not otherwise specified component, which is frequently poorly differentiated. Breast acinic cell carcinoma can demonstrate focal morphologic features similar to microglandular adenosis; these areas are frequently negative for collagen IV and laminin on immunohistochemistry. The true relationship between these 2 entities remains unclear, but we advocate that microglandular adenosis–like areas at the periphery of a breast acinic cell carcinoma should be considered part of the carcinomatous process and re-excised if this process extends to the initial surgical margins.

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“…A detailed morphologic description was provided in 31 of these cases [1,4,7–25]. Shimao et al [9] reported the only case of breast AcCC to date occurring in a male patient.…”

Section: Resultsmentioning

confidence: 99%

Acinic cell carcinoma of breast: morphologic and immunohistochemical review of a rare breast cancer subtype

et al. 2016

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“…AcCCs of the breast are extremely rare. Only 39 cases have been described in the English literature to date, usually as case reports or small case series . In addition to immunoreactivity for serous differentiation markers, AcCCs of the breast have been reported to display a triple‐negative phenotype; interestingly, however, at variance with the common forms of triple‐negative breast cancer (TNBC), breast AcCCs are reported to have indolent clinical behaviour …”

Section: Introductionmentioning

confidence: 99%

Are acinic cell carcinomas of the breast and salivary glands distinct diseases?

et al. 2015

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Aims Acinic cell carcinomas (AcCC) of the breast have been reported to constitute the breast counterpart of salivary gland AcCCs, based on the similarities of their histological and immunohistochemical features. Breast AcCC is a vanishingly rare form of triple-negative breast cancer (TNBC). Recent studies have demonstrated that in TNBCs, the two driver genes most frequently mutated are TP53 (82%) and PIK3CA (10%). We sought to define whether breast AcCCs would harbour TP53 and PIK3CA somatic mutations, and if so, whether these would be present in salivary gland AcCCs. Methods and results Sanger sequencing of the entire coding region of TP53 and of PIK3CA hotspot mutation sites of 10 breast and 20 salivary gland microdissected AcCCs revealed eight TP53 (80%) and one PIK3CA (10%) somatic mutations in breast AcCCs. No somatic mutations affecting these genes were found in the 20 salivary gland AcCCs analysed. Conclusions Our findings demonstrate that breast AcCCs display TP53 and PIK3CA mutations at frequencies similar to those of common types of TNBCs, whereas these genes appear not to be altered in salivary gland AcCCs, suggesting that despite their similar histological appearances, AcCCs of the breast and salivary glands probably constitute unrelated diseases.

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“…ACC affects mainly adult women, with only 1 male patient reported in the literature [74]. ACC can arise in any breast quadrants, presenting as an infiltrative nodule; size varies sometimes reaching large dimensions [75,76]. One case of ACC arising in a fibroadenoma was reported [76].…”

Section: Acinic Cell Carcinoma (Acc)mentioning

confidence: 99%

Triple-negative breast carcinomas of low malignant potential: review on diagnostic criteria and differential diagnoses

et al. 2021

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Triple-negative breast carcinomas constitute a wide spectrum of lesions, mostly being highly aggressive. Nevertheless, some special histologic subtypes can have low malignant potential. The purpose of the present paper is to review diagnostic criteria and prognostic parameters of breast neoplasms of special histotypes. Specifically, adenoid cystic carcinoma, adenomyoepithelioma, acinic cell carcinoma, mucoepidermoid carcinoma, tall cell carcinoma with reverse polarity, and secretory carcinoma will be discussed. For each tumour, definition and morphological and molecular features, together with prognostic parameters, will be presented. Paradigmatic cases will be illustrated.

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The first case of acinic cell carcinoma of the breast within a fibroadenoma: Case report

Cited by 8 publications

References 20 publications

Acinic cell carcinoma of breast: morphologic and immunohistochemical review of a rare breast cancer subtype

Acinic cell carcinoma of breast: morphologic and immunohistochemical review of a rare breast cancer subtype

Are acinic cell carcinomas of the breast and salivary glands distinct diseases?

Triple-negative breast carcinomas of low malignant potential: review on diagnostic criteria and differential diagnoses

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