The Flat Cat

Murphy, Kate; Hibbert, Angie

doi:10.1177/1098612x13477538

Cited by 4 publications

(1 citation statement)

References 48 publications

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“…The artificial colloid, hydroxyethyl starch (HES), is recommended for the treatment of anesthesia-induced hypotension, for resuscitation and to increase colloid-osmotic pressure in cats [ 1 , 2 ]. Although various doses have been recommended [ 3 , 4 ], no study has thus far evaluated the side effects of HES solutions or established safe doses in cats.…”

Section: Introductionmentioning

confidence: 99%

In vitro effects of 6 % hydroxyethyl starch 130/0.42 solution on feline whole blood coagulation measured by rotational thromboelastometry

Albrecht¹,

Howard

Kovačević

et al. 2016

BMC Vet Res

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BackgroundThe artificial colloid, hydroxyethyl starch (HES), is recommended for intravascular volume expansion and colloid-osmotic pressure enhancement in dogs and cats. A well-known side effect of HES solutions in humans and dogs is coagulopathy. However, HES-associated coagulopathy has thus far not been investigated in cats. The goal of this study was to assess the in vitro effects of 6 % HES 130/0.42 on feline whole blood samples using rotational thromboelastometry (ROTEM). A further goal was to develop feline reference intervals for ROTEM at our institution. In this in vitro experimental study, blood samples of 24 adult healthy cats were collected by atraumatic jugular phlebotomy following intramuscular sedation. Baseline ROTEM analyses (using ex-tem, in-tem and fib-tem assays) were performed in duplicate. Additionally, ROTEM analyses were performed on blood samples after dilution with either Ringer’s acetate (RA) or 6 % HES 130/0.42 (HES) in a 1:6 dilution (i.e. 1 part solution and 6 parts blood).ResultsCoefficients of variation of duplicate measures were below 12 % in all ex-tem assays, 3 of 4 in-tem assays but only 1 of 3 fib-tem assays. Reference intervals were similar albeit somewhat narrower than those previously published. Dilution with both solutions lead to significantly prolonged CT (in-tem), CFT (ex-tem and in-tem), and reduced MCF (ex-tem, in-tem, and fib-tem) and alpha (ex-tem and in-tem). Compared to RA, dilution with HES caused a significant prolongation of CT in fib-tem (P = 0.016), CFT in ex-tem (P = 0.017) and in-tem (P = 0.019), as well as a reduction in MCF in in-tem (P = 0.032) and fib-tem (P = 0.020), and alpha in ex-tem (P = 0.014). However, only a single parameter (CFT in ex-tem) was outside of the established reference interval after dilution with HES.ConclusionsIn vitro hemodilution of feline blood with RA and HES causes a small but significant impairment of whole blood coagulation, with HES leading to a significantly greater effect on coagulation than RA. Further studies are necessary to evaluate the in vivo effects and the clinical significance of these findings.

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Section: Introductionmentioning

confidence: 99%

In vitro effects of 6 % hydroxyethyl starch 130/0.42 solution on feline whole blood coagulation measured by rotational thromboelastometry

Albrecht¹,

Howard

Kovačević

et al. 2016

BMC Vet Res

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Development of a severity scoring system for acute haemorrhage in anaesthetized domestic cats: the CABSS score

Zeiler

Fuller

Rioja³

et al. 2020

Veterinary Anaesthesia and Analgesia

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Effectiveness of intravenous fluid resuscitation in hypotensive cats: 82 cases (2012–2019)

Chalifoux

Hess

Silverstein

2021

J Vet Emergen Crit Care

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Objective: To evaluate the effectiveness of intravenous fluid resuscitation in hypotensive cats in an emergency room setting. Secondary objectives were to investigate changes in heart rate (HR) and body temperature (BT) in response to fluid resuscitation, and the association of these changes with patient survival.Design: Retrospective study.Setting: University teaching hospital. Animals: Eighty-two cats with confirmed hypotension. Interventions: None.Measurements and main results: Medical records from 2012 to 2019 were searched for cats that had documented systemic arterial hypotension (blood pressure measured using a Doppler ultrasonic flow probe [DBP] < 90 mm Hg) on presentation to the emergency room. Data collected included patient characteristics and DBP, HR, and BT before and after fluid resuscitation, type and volume of fluids administered, and outcome. The median DBP before and after resuscitative fluid therapy in all cats was 65 mm Hg (range, 20-85 mm Hg) and 80 mm Hg (range, 20-128 mm Hg), respectively (P < 0.001). However, only 30 cats (37%) were classified as responders to fluid resuscitation (DBP ≥ 90 mm Hg following bolus therapy). The mean HR and median BT before resuscitative fluid therapy was 159/min and 36.7 • C. Following fluid resuscitation, where measured, the mean HR and median BT was 154/min (P = 1.00) and 35.9 • C (P = 1.00). No significant differences in HR and BT were identified between responders and non-responders. Cats had a low survival rate of 7%. All survivors (n = 5) were initially bradycardic (HR < 160/min), compared to only 45% of non-survivors (P = 0.4). Conclusions:Bolus fluid resuscitation effectively increases blood pressure in hypotensive cats; however, it does not result in normalization of blood pressure, HR, or BT in the majority of cases.

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The Flat Cat

Cited by 4 publications

References 48 publications

In vitro effects of 6 % hydroxyethyl starch 130/0.42 solution on feline whole blood coagulation measured by rotational thromboelastometry

In vitro effects of 6 % hydroxyethyl starch 130/0.42 solution on feline whole blood coagulation measured by rotational thromboelastometry

Development of a severity scoring system for acute haemorrhage in anaesthetized domestic cats: the CABSS score

Effectiveness of intravenous fluid resuscitation in hypotensive cats: 82 cases (2012–2019)

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