The flavonoid quercetin suppreses the development of neuropathic pain behavior in rats

Ishii, Norito; Matsuoka, Yoshikazu; Omiya, Hiroki; Taniguchi, Arata; Kaku, Ryuji; Morita, Kyoji

doi:10.1097/00003643-201306001-00667

Cited by 4 publications

(1 citation statement)

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“…The compound was introduced into the mice which induced peripheral neuropathy; the flavonoids rutin and quercetin reduced the production of ROS species by acting as an antioxidant agents and reduced the side effect induced by oxaliplatin [ 195 ]. The flavonoid quercetin reduced the neuropathic pain by inhibition of p -ERK induced in Sprague-Dawley rats by sciatic nerve injury [ 196 ].…”

Section: Effects Of Flavonoids On Human Healthmentioning

confidence: 99%

Important Flavonoids and Their Role as a Therapeutic Agent

et al. 2020

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Flavonoids are phytochemical compounds present in many plants, fruits, vegetables, and leaves, with potential applications in medicinal chemistry. Flavonoids possess a number of medicinal benefits, including anticancer, antioxidant, anti-inflammatory, and antiviral properties. They also have neuroprotective and cardio-protective effects. These biological activities depend upon the type of flavonoid, its (possible) mode of action, and its bioavailability. These cost-effective medicinal components have significant biological activities, and their effectiveness has been proved for a variety of diseases. The most recent work is focused on their isolation, synthesis of their analogs, and their effects on human health using a variety of techniques and animal models. Thousands of flavonoids have been successfully isolated, and this number increases steadily. We have therefore made an effort to summarize the isolated flavonoids with useful activities in order to gain a better understanding of their effects on human health.

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Section: Effects Of Flavonoids On Human Healthmentioning

confidence: 99%