The frequencies of ABO blood groups and of secretors of ABH group substances in peripheral arteriosclerosis

Hall, Robert A.; Bunch, G. A.; Humphrey, Christopher

doi:10.1016/0021-9150(71)90053-0

Cited by 15 publications

(11 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The association with ABO groups (in creased A and decreased 0) seems to be restricted to patients with atherosclerotic occlusion, and this confirms the results in other studies [Kingsburgy, 1971;Hall et al, 1971;Morris and Bouhoutsos, 1973].…”

Section: Resultssupporting

confidence: 80%

See 1 more Smart Citation

HLA Antigens, Blood Groups and Serum Protein Groups in Patients with Intermittent Claudication

Norrgård¹,

Beckman²,

Cedergren³

1989

Hum Hered

View full text Add to dashboard Cite

HLA (A and B) antigens, blood group systems (ABO, Rh, MNSs, P, Kell, Lewis and Duffy) and serum group systems (Hp, Tf, Pi, C3 and C4) were studied in patients with intermittent claudication (IC) and controls. HLA antigen A 28 was significantly more common, and blood group 0 was significantly less common among the patients than among the controls. A comparison between patients with IC and those with abdominal aortic aneurysms showed a significant difference between these two groups concerning the MN blood groups.

show abstract

Section: Resultssupporting

confidence: 80%

“…An increased frequency of blood group A and/or a decreased frequency of blood group 0 has also been found in several pre vious studies of IC patients [Kingsbury, 1971;Hall et al, 1971;Weiss, 1972;Morris and Bouhoutsos, 1973].…”

Section: Resultsmentioning

confidence: 95%

HLA Antigens, Blood Groups and Serum Protein Groups in Patients with Intermittent Claudication

Norrgård¹,

Beckman²,

Cedergren³

1989

Hum Hered

View full text Add to dashboard Cite

show abstract

“…The association between non-O blood type and PAD/intermittent claudication was first noted in the 1970’s by Hall and later Kingsbury [11,15]. Subsequent to these case-control studies, the Framingham Heart Study prospectively investigated the association of ABO blood types and the development of intermittent claudication over a 10-year follow-up period and observed an increased risk in those with non-O blood types in both men and women [12].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies examined the associations between ABO blood type and PAD or intermittent claudication and reported that patients with different blood type had varying risks of lower-extremity atherosclerosis [11–17]. However, the associations of ABO blood type with prevalent PAD and incident PAD in non-white populations is not well studied.…”

Section: Introductionmentioning

confidence: 99%

ABO blood group is associated with peripheral arterial disease in African Americans: The Multi-Ethnic Study of Atherosclerosis (MESA)

Pike

Larson

Wassel

et al. 2017

Thrombosis Research

View full text Add to dashboard Cite

Introduction Peripheral artery disease (PAD) affects 8.5 million Americans and thus improving our understanding of PAD is critical to developing strategies to reduce disease burden. The objective of the study was to determine the association of ABO blood type with ankle brachial index (ABI) as well as prevalent and incident PAD in a multi-ethnic cohort. Methods The Multi-Ethnic Study of Atherosclerosis includes non-Hispanic White, African, Hispanic, and Chinese Americans aged 45–84. ABO blood type was estimated using ABO genotypes in 6027 participants who had ABI assessed at the baseline exam. Associations with ABO blood type were evaluated categorically and under an additive genetic model by number of major ABO alleles. After excluding those with ABI>1.4, prevalent PAD was defined as ABI≤ 0.9 at baseline and incident PAD as ABI≤0.9 for 5137 participants eligible for analysis. Results There were 222 prevalent cases and 239 incident cases of PAD. In African Americans, each additional copy of the A allele was associated with a 0.02 lower baseline ABI (p=0.006). Each copy of the A allele also corresponded to 1.57-fold greater odds of prevalent PAD (95% CI, 1.17–2.35; p=0.004), but was not associated with incident PAD. No associations were found in other racial/ethnic groups for ABI, prevalent PAD, or incident PAD across all races/ethnicities. Conclusions Blood type A and the A allele count were significantly associated with baseline ABI and prevalent PAD in African Americans. Further research is needed to confirm and study the mechanisms of this association in African Americans.

show abstract

“…S ince the 1960s and the early 1970s, many studies have reported a relationship between the ABO blood group and the risk of coronary heart disease, 1,2 atherosclerosis, 3,4 and venous thromboembolic disease. 1,5 In addition, Ͼ15 reports have established an association between the ABO blood group and plasma levels of factor VIII 6 -9 and von Willebrand factor (vWF).…”

mentioning

confidence: 99%

Activated Partial Thromboplastin Time

Encyclopedic Reference of Molecular Pharmacology

View full text Add to dashboard Cite

Abstract-Lower levels of factor VIII and von Willebrand factor (vWF) have been reported in individuals with blood type O compared with individuals with other ABO blood types. However, this relationship has been demonstrated only by association studies and not by linkage studies. Also, it is not clear whether the ABO locus exerts a functional effect directly on these plasma factors or whether the ABO locus is in linkage disequilibrium with another locus that controls these factors. To distinguish between these 2 possibilities, we applied new statistical methods combining linkage and association tests in a pedigree-based sample. In contrast to most previous studies that used the ABO phenotypes, our study used the ABO genotypes, permitting us to distinguish AO from AA and BO from BB. Our results clearly showed significant linkage between the ABO locus and vWF antigen (Pϭ0.00075). In addition, factor VIII coagulant activity and activated partial thromboplastin time showed suggestive linkage with the ABO locus (Pϭ0.10 and Pϭ0.13). All 3 plasma phenotypes showed significant differences between OO and non-OO genotypes. In addition, vWF antigen exhibited significant differences between O heterozygotes and non-OO homozygotes. This study is unique because it used a combined linkage and association test, which indicated that the ABO locus itself has a functional effect on these plasma phenotypes. (Arterioscler Thromb Vasc

show abstract

The frequencies of ABO blood groups and of secretors of ABH group substances in peripheral arteriosclerosis

Cited by 15 publications

References 7 publications

HLA Antigens, Blood Groups and Serum Protein Groups in Patients with Intermittent Claudication

HLA Antigens, Blood Groups and Serum Protein Groups in Patients with Intermittent Claudication

ABO blood group is associated with peripheral arterial disease in African Americans: The Multi-Ethnic Study of Atherosclerosis (MESA)

Activated Partial Thromboplastin Time

Contact Info

Product

Resources

About