The G Protein-Coupled Receptor Agtrl1b Regulates Early Development of Myocardial Progenitors

Scott, Ian C.; Masri, Bernard; D’Amico, Leonard A.; Jin, Suk‐Won; Jungblut, Benno; Wehman, Ann M.; Baier, Herwig; Audigier, Yves; Stainier, Didier Y. R.

doi:10.1016/j.devcel.2007.01.012

Cited by 163 publications

(211 citation statements)

References 43 publications

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“…Loss of Apela in zebrafish results in embryonic death, with the mutant embryos manifesting failure of heart formation, posterior accumulation of blood cells, malformation of pharyngeal endoderm, and abnormal left-right positioning and formation of the liver. The similarity of the phenotypes of Apela-deficient embryos to those of Aplnr mutants (Scott et al, 2007;Zeng et al, 2007) validates the function of Apela as the agonist for Aplnr (Fig. 3C).…”

Section: (3) Apelamentioning

confidence: 85%

Hidden Peptides Encoded by Putative Noncoding RNAs

Matsumoto

Nakayama

2018

Cell Struct. Funct.

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Although the definition of a noncoding RNA (ncRNA) is an RNA molecule that does not encode a protein, recent evidence has revealed that some ncRNAs are indeed translated to give rise to small polypeptides (usually containing fewer than 100 amino acids). Despite their small size, however, these peptides are often biologically relevant in that they are required for a variety of cellular processes. In this review, we summarize the production and functions of peptides that have been recently identified as translation products of putative ncRNAs.4

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Section: (3) Apelamentioning

confidence: 85%

Hidden Peptides Encoded by Putative Noncoding RNAs

Matsumoto

Nakayama

2018

Cell Struct. Funct.

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“…Recently the apelinergic system has been described to promote embryonic and tumor angiogenesis [19,9,43]. Growing evidences of apelin/APJ involvement in embryonic events currently extend beyond vascular development, into ocular [20] and heart development [42,49,14].…”

Section: Introductionmentioning

confidence: 99%

The apelinergic system in the developing lung: Expression and signaling

et al. 2011

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a b s t r a c tApelin and its receptor APJ constitute a signaling pathway best recognized as an important regulator of cardiovascular homeostasis. This multifunctional peptidergic system is currently being described to be involved in embryonic events which extend into vascular, ocular and heart development. Additionally, it is highly expressed in pulmonary tissue. Therefore, the aim of this study was to investigate the role of apelinergic system during fetal lung development. Immunohistochemistry and Western blot analysis were used to characterize apelin and APJ expression levels and cellular localization in normal fetal rat lungs, at five different gestational ages as well as in the adult. Fetal rat lung explants were cultured in vitro with increasing doses of apelin. Treated lung explants were morphometrically analyzed and assessed for MAPK signaling modifications. Both components of the apelinergic system are constitutively expressed in the developing lung, with APJ exhibiting monomeric, dimeric and oligomeric forms in the pulmonary tissue. Pulmonary epithelium also displayed constitutive nuclear localization of the receptor. Fetal apelin expression is higher than adult expression. Apelin supplementation inhibitory effect on branching morphogenesis was associated with a dose dependent decrease in p38 and JNK phosphorylation. The results presented provide the first evidence of the presence of an apelinergic system operating in the developing lung. Our findings also suggest that apelin inhibits fetal lung growth by suppressing p38 and JNK signaling pathways.

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“…The apelin/APJ system plays a role in the cardiovascular system of Xenopus laevis 24 and of zebrafish. 25 Xenopus apelin (Xapelin) is expressed in the region around the presumptive blood vessels during early embryogenesis as Xenopus APJ (Xmsr). Knockdown of Xapelin or Xmsr resulted in a defect of blood vessel formation in the posterior cardinal vein, intersomitic vessels, and vitelline vessels.…”

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confidence: 99%

Apelin Attenuates UVB-Induced Edema and Inflammation by Promoting Vessel Function

Sawane

Kidoya

Muramatsu

et al. 2011

The American Journal of Pathology

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Apelin, the ligand of the G protein-coupled receptor APJ, is involved in the regulation of cardiovascular functions, fluid homeostasis, and vessel formation. Recent reports indicate that apelin secreted from endothelial cells mediates APJ regulation of blood vessel caliber size; however, the function of apelin in lymphatic vessels is unclear. Here we report that APJ was expressed by human lymphatic endothelial cells and that apelin induced migration and cord formation of lymphatic endothelial cells dose-dependently in vitro. Furthermore, permeability assays demonstrated that apelin stabilizes lymphatic endothelial cells. In vivo, transgenic mice harboring apelin under the control of keratin 14 (K14-apelin) exhibited attenuated UVBinduced edema and a decreased number of CD11b-positive macrophages. Moreover, activation of apelin/APJ signaling inhibited UVB-induced enlargement of lymphatic and blood vessels. Finally, K14-apelin mice blocked the hyperpermeability of lymphatic vessels in inflamed skin. These results indicate that apelin plays a functional role in the stabilization of lymphatic vessels in inflamed tissues and that apelin might be a suitable target for prevention of UVB-induced inflammation.

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The G Protein-Coupled Receptor Agtrl1b Regulates Early Development of Myocardial Progenitors

Cited by 163 publications

References 43 publications

Hidden Peptides Encoded by Putative Noncoding RNAs

Hidden Peptides Encoded by Putative Noncoding RNAs

The apelinergic system in the developing lung: Expression and signaling

Apelin Attenuates UVB-Induced Edema and Inflammation by Promoting Vessel Function

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