The Gene Polymorphism of Angiotensin-Converting Enzyme Intron Deletion and Angiotensin-Converting Enzyme G2350A in Patients With Left Ventricular Hypertrophy: A Meta-analysis

Fajar, Jonny Karunia; Pikir, Budi Susetyo; Sidarta, Erdo Puncak; Saka, Putu Nina Berlinda; Akbar, Rizal Rahmanda; Heriansyah, Teuku

doi:10.1016/j.ihj.2019.07.002

Cited by 12 publications

(8 citation statements)

References 48 publications

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“…The analysis of the genetic influence of the ACE I/D polymorphism on CMR and related outcomes should also consider age, physical activity and diet, among others [16]; moreover, sex differences can mediate the associations [4,16]. It should be note that most of the articles include a sample with a mean age over 55 years [10], therefore, the analysis in other ranges of age could be interesting.…”

Section: Introductionmentioning

confidence: 99%

Influence of ACE Gene I/D Polymorphism on Cardiometabolic Risk, Maximal Fat Oxidation, Cardiorespiratory Fitness, Diet and Physical Activity in Young Adults

Montes-de-Oca-García

Pérez‐Bey

Velázquez-Díaz

et al. 2021

IJERPH

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There is controversy about the relationship between ACE I/D polymorphism and health. Seventy-four healthy adults (n = 28 women; 22.5 ± 4.2 years) participated in this cross-sectional study aimed at determining the influence of ACE I/D polymorphism, ascertained by polymerase chain reaction, on cardiometabolic risk (i.e., waist circumference, body fat, blood pressure (BP), glucose, triglycerides, and inflammatory markers), maximal fat oxidation (MFO), cardiorespiratory fitness (maximal oxygen uptake), physical activity and diet. Our results showed differences by ACE I/D polymorphism in systolic BP (DD: 116.4 ± 11.8 mmHg; ID: 116.7 ± 6.3 mmHg; II: 109.4 ± 12.3 mmHg, p = 0.035) and body fat (DD: 27.3 ± 10.8%; ID: 22.6 ± 9.7%; II: 19.3 ± 7.1%, p = 0.030). Interestingly, a genotype*sex interaction in relativized MFO by lean mass (p = 0.048) was found. The DD polymorphism had higher MFO values than ID/II polymorphisms in men (8.4 ± 3.0 vs. 6.5 ± 2.9 mg/kg/min), while the ID/II polymorphisms showed higher R-MFO values than DD polymorphism in women (6.6 ± 2.3 vs. 7.6 ± 2.6 mg/kg/min). In conclusion, ACE I/D polymorphism is apparently associated with adiposity and BP, where a protective effect can be attributed to the II genotype, but not with cardiorespiratory fitness, diet and physical activity. Moreover, our study highlighted that there is a sexual dimorphism in the influence of ACE I/D gene polymorphism on MFO.

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Section: Introductionmentioning

confidence: 99%

Influence of ACE Gene I/D Polymorphism on Cardiometabolic Risk, Maximal Fat Oxidation, Cardiorespiratory Fitness, Diet and Physical Activity in Young Adults

Montes-de-Oca-García

Pérez‐Bey

Velázquez-Díaz

et al. 2021

IJERPH

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“…14 In the protein subunit vaccine, the immunogenic property is specific isolated proteins from SARS-COV2 virus (S glycoprotein), which is responsible for receptor binding to cellular ACE-2. [65][66][67] This type of vaccine is similar to a vector vaccine, in which the S protein is produced to confer protection against COVID-19. 68 Of those possible mechanisms, the inactivated vaccine may target a wide variety of epitopes, 69 and therefore, this type of vaccine may have a wide protection against COVID-19 variants of concern compared to other types of COVID-19 vaccines.…”

Section: Discussionmentioning

confidence: 99%

Seroconversion rates among different designs of COVID-19 vaccines: a network meta-analysis of randomized controlled trials

et al. 2022

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BACKGROUND: The COVID-19 vaccination program, which uses various types of vaccines, has been applied since the beginning of 2021. However, the efficacy in the context of seroconversion rate remains unclear. OBJECTIVE: To assess the seroconversion rates among different COVID-19 vaccines using a network meta-analysis approach. METHODS: A network meta-analysis of randomized controlled trials (RCTs) was conducted during the study period. Data of interest, such as seroconversion rate and the type of COVID-19 vaccine, were extracted from each study. The analysis was performed using single-arm analysis by calculating the cumulative seroconversion rate. A network meta-analysis was conducted using the Bayesian method. RESULTS: A total of 31 RCTs were included in our analysis. Our pooled calculation revealed that the seroconversion rates of inactivated messenger ribonucleic acid (mRNA), protein subunit, and vector COVID-19 vaccines during the follow-up periods were 93.2%, 93.9%, 65.3%, and 54.7%, respectively, at ≤ 15 days; 96.0%, 94.8%, 91.2%, and 89.7%, respectively, between days 16–30; and 98.5%, 98.6%, 98.5%, and 96.2%, respectively, between days 31–60.The indirect comparison revealed that in the follow-up periods of ≤ 15 and 16–30 days, the inactivated and mRNA COVID-19 vaccines had superior seroconversion rates compared with those of the protein subunit and vector vaccines. In the follow-up period of 31–60 days, the highest seroconversion rates were found in the inactivated, mRNA, and protein subunit COVID-19 vaccines. CONCLUSION: This study provides valuable information regarding the comparison of seroconversion rates of COVID-19 vaccines.

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“…Also, it was not found any significant association between H-C and E-C groups (p>0.05). Fajar et al [29] reviewed a meta-analysis to evaluate the correlation between ACE I/D and ACE G2350A polymorphisms for left ventricular hypertrophy. Previous studies had shown that D allele of ACE I/D was associated with an elevated level of ACE in the circulation [30][31][32][33] and increased ACE mRNA expressions [34] and activity [35].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Elite Athletes and Essential Hypertension Patients for Angiotensin-Converting Enzyme (ACE) I/D and ACE G2350A Gene Polymorphisms

Günel¹,

Eker²,

Gumusoglu‐Acar³

et al. 2020

BJSTR

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Objective: Angiotensin-converting enzyme (ACE) gene produces an ACE protein which is the key component of the renin-angiotensin system and contains several polymorphisms which affects the physical performance that is significantly important for athletes. Insertion/deletion (I/D) and G2350A polymorphisms which have one of the most powerful influences in the ACE gene is known to regulate cardiovascular mechanisms by taking a role in angiotensin-system. Methods:The present study aimed to investigate the genetic association and haplotypes formed by rs1799752 (ACE I/D) and rs4343 (ACE G2350A) polymorphisms in essential hypertension patients, elite athletes and healthy controls in total 79 subjects (27 hypertension patients, 27 elite athletes and 25 control group individuals) from Turkish population. In this study, ACE I/D and G2350A polymorphisms were genotyped by using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method and identified by bioanalyzer after restriction digestion. Results:The prevalence of genotype frequencies of the ACE rs1799752 II/ID/DD was 3.7%, 44.44%, 51.85% in hypertension patients; 3.7%, 33.33%, 62.96% in elite athletes and 12%, 24%, 64% in healthy controls, respectively. Also, the prevalence of genotype frequencies of the ACE rs4343 GG/GA/AA was 7.41%, 77.78%, 14.81% in hypertension patients; 0%, 77.78%, 22.22% in elite athletes and 4%, 84%, 12% in healthy controls, respectively. Conclusion:Our data suggest that "D" allele for I/D and "A" allele for G2350A polymorphisms of ACE gene may have a potential role with a large number of patients and control groups in Turkish population.

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The Gene Polymorphism of Angiotensin-Converting Enzyme Intron Deletion and Angiotensin-Converting Enzyme G2350A in Patients With Left Ventricular Hypertrophy: A Meta-analysis

Cited by 12 publications

References 48 publications

Influence of ACE Gene I/D Polymorphism on Cardiometabolic Risk, Maximal Fat Oxidation, Cardiorespiratory Fitness, Diet and Physical Activity in Young Adults

Influence of ACE Gene I/D Polymorphism on Cardiometabolic Risk, Maximal Fat Oxidation, Cardiorespiratory Fitness, Diet and Physical Activity in Young Adults

Seroconversion rates among different designs of COVID-19 vaccines: a network meta-analysis of randomized controlled trials

Comparison of Elite Athletes and Essential Hypertension Patients for Angiotensin-Converting Enzyme (ACE) I/D and ACE G2350A Gene Polymorphisms

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