The GenusPatrinia: A Review of Traditional Uses, Phytochemical and Pharmacological Studies

Abstract

The aim of the present review is to comprehensively outline the botanical description, traditional uses, phytochemistry, pharmacology and toxicology of Patrinia, and to discuss possible trends for the further study of medicinal plants from the genus Patrinia. The genus Patrinia plays an important role in Asian medicine for the treatment of erysipelas, conjunctival congestion with swelling and pain, peri-appendicular abscesses, lung carbuncle, dysentery, leucorrhea, and postpartum disease. More than 210 chemical constituents have been isolated and identified from Patrinia plants, especially P. scabiosaefolia Fisch., P. scabra Bunge, P. villosa Juss., P. heterophylla Bunge and P. rupestris(Pall.) Juss[Formula: see text] Of these compounds, triterpenoids and saponins, iridoids, flavonoids, and lignans are the major or active constituents. Both in vitro and in vivo studies have indicated that some monomer compounds and crude extracts from the genus Patrinia possess wide pharmacological activities, including antitumor, anti-inflammatory, antibacterial, and antiviral effects. In addition, they have been shown to have valuable and positive effects on the immune and nervous system in experimental animals. There are also some reports on the clinical uses and toxicity of these species. However, few reports have been published concerning the material identification or quality control of Patrinia species, and the clinical uses and toxic effects of these plants are relatively sparse. More attention must be given to these issues.

YYFZBJS ameliorates colorectal cancer progression in ApcMin/+ mice by remodeling gut microbiota and inhibiting regulatory T-cell generation

“…Previous studies have confirmed that all three components of YYFZBJS have potent anti-cancer effect by inhibiting intestinal tumor formation [ 28 – 30 ]. Other recent findings have confirmed that, coix seed and patrinia, the major active constituents of YYFZBJS, regulate T lymphocytes and improve immunity [ 54 , 55 ]. In our current study, we used a simple and accurate UPLC-MS technology to simultaneously separate and identify three drug components to evaluate YYFZBJS.…”

The Herba Patriniae (Caprifoliaceae): A review on traditional uses, phytochemistry, pharmacology and quality control

“…Herba Patriniae has a wide geographical distribution, mainly in East Asia and North America ( He et al, 2017 ). Some plants, such as Sonchus Arvensis L., Sonchus Asper Vill, Sonchus oleraceus L. etc , may be confused as Herba Patriniae ( Lu, 1996 ), and hence, these adulterants of Herba Patriniae should be exclude when clinical use.…”

Chemical Composition of Patrinia scabiosifolia Flower Absolute and Its Migratory and Proliferative Activities in Human Keratinocytes

“…[8] The plants were used as an oriental traditional medicine for the treatment of intestinal disorders such as liver abscess, enteritis and appendicitis. [9,10] Previous investigators reported that PS or its extracts has multiple biological activities such as antitumor, anti-inflammatory and antioxidant effects. [11,12] Studies have been done on a number of natural materials that can facilitate skin biological activities related to skin generation and wound healing.…”