The growing menace of drug resistant pathogens and recent strategies to overcome drug resistance: A review

Harikumar, Gayathri; Krishanan, Kannabiran

doi:10.1016/j.jksus.2022.101979

Cited by 21 publications

(12 citation statements)

References 64 publications

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“…The resistance of bacteria to antibiotics has become a serious problem worldwide. It is predicted that by 2050, around 10 million people will die from infections due to antibiotic-resistant bacteria [ 1 ]. Antibiotic resistance also has negative impacts on healthcare costs.…”

Section: Introductionmentioning

confidence: 99%

Solution of the Drug Resistance Problem of Escherichia coli with Silver Nanoparticles: Efflux Effect and Susceptibility to 31 Antibiotics

et al. 2023

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The current work is a continuation of our studies focused on the application of nanoparticles of metallic silver (AgNPs) to address the global problem of antibiotic resistance. In vivo, fieldwork was carried out with 200 breeding cows with serous mastitis. Ex vivo analyses showed that after the cow was treated with an antibiotic-containing drug DienomastTM, E. coli sensibility to 31 antibiotics decreased by 27.3%, but after treatment with AgNPs, it increased by 21.2%. This could be explained by the 8.9% increase in the portion of isolates showing an efflux effect after DienomastTM treatment, while treatment with Argovit-CTM resulted in a 16.0% drop. We verified the likeness of these results with our previous ones on S. aureus and Str. dysgalactiae isolates from mastitis cows processed with antibiotic-containing medicines and Argovit-CTM AgNPs. The obtained results contribute to the recent struggle to restore the efficiency of antibiotics and to preserve the wide range of antibiotics on the world market.

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Section: Introductionmentioning

confidence: 99%

Solution of the Drug Resistance Problem of Escherichia coli with Silver Nanoparticles: Efflux Effect and Susceptibility to 31 Antibiotics

et al. 2023

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“…We have already known that the structures of over 80,000 natural products from microbes (Demain, 2014 ) and over 80% of the antibiotics are produced by microbes (de Lima Procópio et al, 2012 ) since the discovery of penicillin in 1928 (Demain, 2014 ). Due to the extensive use of antibiotics for common infections, pathogens are showing high resistance (Harikumar and Krishanan, 2022 ); therefore, there is an urgent need for finding novel drugs. Grube made a point of view that microbial symbioses have a high potential leading to a wide variety of unique structures and metabolic activities (Grube and Berg, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Discovery and excavation of lichen bioactive natural products

et al. 2023

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Lichen natural products are a tremendous source of new bioactive chemical entities for drug discovery. The ability to survive in harsh conditions can be directly correlated with the production of some unique lichen metabolites. Despite the potential applications, these unique metabolites have been underutilized by pharmaceutical and agrochemical industries due to their slow growth, low biomass availability, and technical challenges involved in their artificial cultivation. At the same time, DNA sequence data have revealed that the number of encoded biosynthetic gene clusters in a lichen is much higher than in natural products, and the majority of them are silent or poorly expressed. To meet these challenges, the one strain many compounds (OSMAC) strategy, as a comprehensive and powerful tool, has been developed to stimulate the activation of silent or cryptic biosynthetic gene clusters and exploit interesting lichen compounds for industrial applications. Furthermore, the development of molecular network techniques, modern bioinformatics, and genetic tools is opening up a new opportunity for the mining, modification, and production of lichen metabolites, rather than merely using traditional separation and purification techniques to obtain small amounts of chemical compounds. Heterologous expressed lichen-derived biosynthetic gene clusters in a cultivatable host offer a promising means for a sustainable supply of specialized metabolites. In this review, we summarized the known lichen bioactive metabolites and highlighted the application of OSMAC, molecular network, and genome mining-based strategies in lichen-forming fungi for the discovery of new cryptic lichen compounds.

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“…Because of the influence on the AMR issue, focus is progressively moving to the utilization of bioactive components derived from plant species used as herbal remedies, which may provide both antibacterial and antioxidant sources that have an impact on human health (Cheesman et al, 2017;Gupta & Birdi, 2017;Harikumar & Krishanan, 2022). The antimicrobial capabilities of this herbal plant are attributed to its capacity to create many secondary metabolites with rather complicated structures that have antibacterial and antioxidant characteristics (Chassagne et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

An overview of the role of Zingiber officinale as an antimicrobial resistance (AMR) solution and a source of antioxidants

et al. 2023

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In this review, we describe the known mechanisms of antimicrobial resistance which was increasing in this era, due to the misuse of antimicrobial agents such as antibiotics, or genetic and phenotypic mechanisms. In this review, the concerns, especially addressed by designated researchers in their study and WHO in their observations and reports, regarding the types or strains of bacteria with antimicrobial resistances were described. In addition, the predicted mechanisms that promote the development and occurrence of antimicrobial resistances, such as bacterial biofilm formation, horizontal gene transfer, genetic mutations, free DNA which contains antimicrobial resistance genes, plasmids transfer through transformation or conjugation from bacterial cell to cell were well described. In addition, we also tried to describe the use of Z. officinale. The antimicrobial capabilities of this herbal plant are attributed to its capacity to create many secondary metabolites with rather complicated structures that have antibacterial and antioxidant characteristics. Z. officinale had been used for many kinds of diseases treatment traditionally. And along the way, the advance techniques of research in chemistry and biology fields had found out the composition and bioactive compound. In this review, the common online databases such as PubMed, Semantic Scholar, Crossref, Medline, Scopus, and Web of Science (WoS) were utilized to conduct literature searches. According to recent progress of antimicrobial cases observed, the efforts to strengthen the surveillance, general health systems, tightened the antimicrobial medicine distribution rules, and education for public are indeed needed.

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The growing menace of drug resistant pathogens and recent strategies to overcome drug resistance: A review

Cited by 21 publications

References 64 publications

Solution of the Drug Resistance Problem of Escherichia coli with Silver Nanoparticles: Efflux Effect and Susceptibility to 31 Antibiotics

Solution of the Drug Resistance Problem of Escherichia coli with Silver Nanoparticles: Efflux Effect and Susceptibility to 31 Antibiotics

Discovery and excavation of lichen bioactive natural products

An overview of the role of Zingiber officinale as an antimicrobial resistance (AMR) solution and a source of antioxidants

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