The gustin (CA6) gene polymorphism, rs2274333 (A/G), is associated with fungiform papilla density, whereas PROP bitterness is mostly due to TAS2R38 in an ethnically-mixed population

Barbarossa, Iole Tomassini; Melis, Melania; Mattes, Mitchell Z.; Calò, Carla Maria; Muroni, Patrizia; Crnjar, Roberto Massimo; Tepper, Beverly J.

doi:10.1016/j.physbeh.2014.09.011

Cited by 60 publications

(67 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Padiglia et al [27] found that polymorphisms in the CA6 gene influence the binding of gustin and zinc, thus impacting taste function. In addition, bitter taste sensitivity is inversely associated with fungiform papillae density [44,47], and gustin is a reported trophic factor involved in taste bud growth and development [33,48,49]. We found that homozygosity of the CA6 -rs227432 C allele was associated with increased risk of struggles with control during mealtimes, suggesting that gustin polymorphisms may play a role in children's picky eating behavior.…”

Section: Discussionmentioning

confidence: 88%

Variants in Chemosensory Genes Are Associated with Picky Eating Behavior in Preschool-Age Children

et al. 2017

View full text Add to dashboard Cite

Background/Aims: Picky eating is prevalent among preschoolers and is associated with risk of both underweight and overweight. Although differences in taste perception may be due to genetic variation, it is unclear whether these variations are related to picky eating behavior. The aim of this study was to investigate the association of 6 single nucleotide polymorphisms (SNPs) in 5 candidate genes related to chemosensory perception with picky eating behavior and adiposity in a cohort of preschool-aged children. Methods: Parents of 2- to 5-year-old non-Hispanic white preschoolers (n = 153) responded to survey questions on demographics, and information regarding their child's breastfeeding history and picky eating behavior. Height and weight were measured to calculate body mass index (BMI) z-scores using standard growth charts, and saliva was collected for genotyping. Generalized linear models were used to examine associations between picky eating behavior and BMI z-scores with genetic variation. Results: When controlling for child age, sex, breastfed status, and parent education level, SNPs in TAS2R38 (rs713598) and CA6 (rs2274327) were associated with picky eating behavior in children. There was no association between SNPs and BMI z-scores. Conclusion: Genes related to chemosensory perception may play a role in children's picky eating behavior.

show abstract

Section: Discussionmentioning

confidence: 88%

Variants in Chemosensory Genes Are Associated with Picky Eating Behavior in Preschool-Age Children

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Evidence has suggested that the TAS2R38 PAV haplotype is associated with the perception of higher concentrations of PROP, whereas the CA6 A allele is relevant to sensing lower PROP concentrations [16]. However, a subsequent study reported that the variant CAVI was only associated with fungiform papilla density, whereas T2R38 modified bitterness sensing [32]. In addition to those observations regarding bitterness sensing, the present study adds more evidence for the combined effect of both T2R38 and CAVI in disease etiology.…”

Section: Discussionmentioning

confidence: 99%

Variations in the bitterness perception-related genes TAS2R38 and CA6 modify the risk for colorectal cancer in Koreans

Choi

Lee

et al. 2017

Oncotarget

View full text Add to dashboard Cite

Bitterness perception is known to be an important factor in individuals' dietary behaviors and is also associated with the sensing of nutritious/noxious molecules for subsequent metabolic responses in multiple organs. Therefore, the genetic variation in bitterness sensing may be associated with diet-related diseases, including colorectal cancer (CRC). We investigated the influence of variations in the bitterness-sensing genes taste receptor type 2 member 38 (TAS2R38) and carbonic anhydrase 6 (CA6) on the consumption of food, tobacco and alcohol and the risk of CRC in Koreans. The study population consisted of 681 cases and 1361 controls, and their intake of vegetables, fruits, fiber, fat-food and sweets was analyzed. The genotypes for TAS2R38 A49P, V262A and I296V and CA6 rs2274333 A/G were assessed using the MassArray technique. Our findings suggested that the TAS2R38 diplotype, CA6 rs2274333 and their combined genotype had a negligible influence on dietary and alcohol intake. The combined TAS2R38-CA6 AVI/AVI-AA genotype was associated with higher tobacco consumption than the other genotypes in CRC cases only. However, the genetic variations were a significant risk factor for CRC. The TAS2R38 AVI/AVI diplotype and CA6 G allele were associated with a reduced risk of CRC. Moreover, when the combined genotypes of the subjects were analyzed, possessing both the variant diplotype/variant allele (AVI/AVI+G*) was associated with a greater reduction in the risk of CRC (adjusted OR = 0.49; 95%CI: 0.34-0.74). In summary, variations in the bitterness perception genes TAS2R38 and CA6 did not influence the examined food intake in Koreans. However, those genetic variants were a decisive modifying factor of CRC susceptibility.

show abstract

“…Subjects who gave lower intensity ratings to PROP solutions than those to NaCl were classified as PROP non-tasters, those who gave similar ratings to the two stimuli were classified as medium tasters, and those who gave higher ratings to PROP than to NaCl were classified as super-tasters. After a 1-hour period for recovering, the assignment of each subject to a PROP taster group (super-taster, medium taster, or non-taster) was validated using the impregnated paper screening test3336. This method is based on the ratings of two 2 paper disks, one impregnated with NaCl (1.0 mol/l) and the other with PROP solution (50 mmol/1).…”

Section: Methodsmentioning

confidence: 99%

“…Individuals can be classified as PROP non-tasters, medium-tasters or super-tasters using well-established screening and classification by psychophysical methods3313233343536. Non-tasters are subjects who detect PROP only at high concentrations, or not at all, medium-tasters are those who perceive PROP as moderately bitter, while super-tasters are subjects who experience intense bitter sensation from the compound, even at very low concentrations.…”

mentioning

confidence: 99%

First objective evaluation of taste sensitivity to 6-n-propylthiouracil (PROP), a paradigm gustatory stimulus in humans

Sollai

Melis

Pani

et al. 2017

Sci Rep

Self Cite

View full text Add to dashboard Cite

Practical and reliable methods for the objective measure of taste function are critically important for studying eating behavior and taste function impairment. Here, we present direct measures of human gustatory response to a prototypical bitter compound, 6-n-propyltiouracil (PROP), obtained by electrophysiological recordings from the tongue of subjects who were classified for taster status and genotyped for the specific receptor gene (TAS2R38), and in which taste papilla density was determined. PROP stimulation evoked negative slow potentials that represent the summated depolarization of taste cells. Depolarization amplitude and rate were correlated with papilla density and perceived bitterness, and associated with taster status and TAS2R38. Our study provides a robust and generalizable research tool for the quantitative measure of peripheral taste function, which can greatly help to resolve controversial outcomes on the PROP phenotype role in taste perception and food preferences, and be potentially useful for evaluating nutritional status and health.

show abstract

The gustin (CA6) gene polymorphism, rs2274333 (A/G), is associated with fungiform papilla density, whereas PROP bitterness is mostly due to TAS2R38 in an ethnically-mixed population

Cited by 60 publications

References 62 publications

Variants in Chemosensory Genes Are Associated with Picky Eating Behavior in Preschool-Age Children

Variants in Chemosensory Genes Are Associated with Picky Eating Behavior in Preschool-Age Children

Variations in the bitterness perception-related genes TAS2R38 and CA6 modify the risk for colorectal cancer in Koreans

First objective evaluation of taste sensitivity to 6-n-propylthiouracil (PROP), a paradigm gustatory stimulus in humans

Contact Info

Product

Resources

About