The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls

Abstract

Patients with PSC exhibited a gut microbial signature distinct from both HC and UC without liver disease, but similar in PSC with and without IBD. The genus, which is also associated with other chronic inflammatory and fibrotic conditions, was enriched in PSC.

The Gut Microbiota and the Hepatologist: Will Our Bugs Prove to be the Missing Link?

“…An increased abundance of Enterococcus was associated with increased levels of serum alkaline phosphatase. Similar findings were reported by Kummen et al [33] , who found that the abundance of the genus Veillonella was markedly increased in PSC compared to healthy controls and patients with ulcerative colitis. In our own study, we found a distinctive population of mucosa-adherent bacteria in patients with PSC-IBD, showing significant increases in Escherichia, Lachnospiraceae and Megasphera along with a reduced abundance of Prevotella and Roseburia and a near-absence of Bacteroides [34] .…”

Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy

“…Recurrent urinary tract infections are a risk factor for the development of PBC 34 . Veillonella genus has recently been associated with PSC and recurrent CD 13 35 . Veillonella was also found in severe inflammatory conditions including endocarditis and cystic fibrosis 36 37.…”

Gut microbiome and liver diseases

“…Primary sclerosing cholangitis (PSC) is commonly observed in patients with IBD and recent studies have investigated the gut microbiome in this disorder 61. Here, 16S rRNA gene sequencing performed in 85 patients with PSC demonstrated that such patients independent of the presence of IBD had a reduced bacterial diversity compared with healthy controls.…”