The Gut Microbiota during a Behavioral Weight Loss Intervention

Abstract

Altered gut microbiota has been linked to obesity and may influence weight loss. We are conducting an ongoing weight loss trial, comparing daily caloric restriction (DCR) to intermittent fasting (IMF) in adults who are overweight or obese. We report here an ancillary study of the gut microbiota and selected obesity-related parameters at the baseline and after the first three months of interventions. During this time, participants experienced significant improvements in clinical health measures, along with altered composition and diversity of fecal microbiota. We observed significant associations between the gut microbiota features and clinical measures, including weight and waist circumference, as well as changes in these clinical measures over time. Analysis by intervention group found between-group differences in the relative abundance of Akkermansia in response to the interventions. Our results provide insight into the impact of baseline gut microbiota on weight loss responsiveness as well as the early effects of DCR and IMF on gut microbiota.

A weight-loss model based on baseline microbiota and genetic scores for selection of dietary treatments in overweight and obese population

“…The subscore for MHP-men also included Fusicatenibacter and Odoribacter genera. Fusicatenibacter has been previously associated with greater weight loss [66], whereas Odoribacter abundance was found to be increased after weight loss, but there is a little information about this relation in men [67]. Ruminococcus faecis has not been described as a potential biomarker for weight loss, but it has been associated with a protective effect on liver damage [68].…”

A Non-Randomized Trial Investigating the Impact of Brown Rice Consumption on Gut Microbiota, Attention, and Short-Term Working Memory in Thai School-Aged Children

“…Recent studies focusing on weight loss interventions have shown that changes in microbial profiles are associated with weight loss and an increase in the level of Akkermansia , regardless of intervention types [ 55 , 56 , 57 ]. In this study, we observed a decrease in BMI z-score in a few samples following the SLR intervention in Phase I.…”

Immune-metabolic mechanisms of post-traumatic stress disorder and atherosclerosis

“…PTSD is a trauma-and stressor-related disorder that often occurs after exposure to a single traumatic event (Musazzi et al, 2018). The firstly supported by clinical studies showing altered gut microbiota composition in individuals with PTSD compared to trauma-exposed resilient individuals (Stanislawski et al, 2021;Malan-Muller et al, 2022). In particular, alterations of certain phyla (Actinobacteria, Lentisphaerae, Verrucomicrobia, and Olsenella), despite no significant changes in microbial alpha and beta diversity, were found to be correlated with clinician-administered posttraumatic stress disorder scale scores exhibited by people with PTSD (Hemmings et al, 2017;Malan-Muller et al, 2022).…”