The gut microbiota profile in psoriasis: a Brazilian case-control study

Schade, Lilian; Mesa, Dany; Faria, Adriane Reichert; Santamaria, Jesus Rodriguez; Xavier, Camila Alexandre; Ribeiro, Débora da Silva Freitas; Hajar, Faissal Nemer; Azevedo, Valderílio Feijó

doi:10.1111/lam.13630

Cited by 26 publications

(32 citation statements)

References 29 publications

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“…The enrichment of the Lachnospiraceae family was also highlighted by another study performed on high-fat diet-fed mice administrated with 300 mg/kg/day resveratrol for 16 weeks [ 136 ]. As previously presented, psoriasis patients tend to have lower levels of Lachnospiraceae family and Blautia compared with healthy individuals [ 40 , 137 ]; thus, resveratrol supplementation could lead to improvements in gut microbial diversity among these patients.…”

Section: Gut Microbiome-targeted Therapies For Psoriasismentioning

confidence: 99%

“…Moreover, complement 3 has a negative correlation with Escherichia level [ 38 ], which tends to be higher in psoriasis patients [ 39 ]. According to a study in Brazil that investigated the composition and diversity of the gut microbiota in 21 subjects with psoriasis, when compared to the control group, the psoriasis group showed a decrease in the Lachnospira and Akkermansia muciniphila species [ 40 ]. This decrease in Akkermansia muciniphila was also highlighted by another study that used 16S rDNA sequencing technology to examine microbiota composition in 14 psoriasis patients [ 41 ].…”

Section: Gut Microbiome Alterations In Psoriasismentioning

confidence: 99%

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Gut Microbiota in Psoriasis

et al. 2022

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Psoriasis is a chronic inflammatory skin disease with autoimmune pathogenic characteristics and is caused by chronic inflammation, which results in uncontrolled keratinocyte growth and defective differentiation. The link between the gut microbiota and immune system regulation opened a novel angle to understand the pathogenesis of many chronic multifactorial diseases, including psoriasis. Current evidence suggests that modulation of the gut microbiota, both through dietary approaches and through supplementation with probiotics and prebiotics, could represent a novel therapeutic approach. The present work aims to highlight the latest scientific evidence regarding the microbiome alterations of psoriatic patients, as well as state of the art insights in terms of microbiome-targeted therapies as promising preventive and therapeutic tools for psoriasis.

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Section: Gut Microbiome-targeted Therapies For Psoriasismentioning

confidence: 99%

Section: Gut Microbiome Alterations In Psoriasismentioning

confidence: 99%

Gut Microbiota in Psoriasis

et al. 2022

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“…The reduction of Actinobacteria showed a negative correlation with PASI in 1 study [38]. Two other studies showed a deterioration in the number of Proteobacteria phylum [32,33] while two studies showed a decrease in Tenericutes phylum and Verrucomicrobia phylum in psoriatic patients [30,36].…”

Section: Gut-skin Axis In Psoriasismentioning

confidence: 95%

“…At the phylum level, 6/14 studies showed an increase [26,29,32,33,31,34], while 3/14 reported a decrease [25,35,36] in Firmicutes phylum in psoriatic patients compared to the healthy control group. The number of bacteria belonging to the Bacteroidetes phylum was increased in psoriatic patients only in two studies, while 5/11 studies indicated a decrease [37,26,32,33,31].…”

Section: Gut-skin Axis In Psoriasismentioning

confidence: 99%

Gut Microbiome as a Novel Treatment Strategy for Psoriasis

Zając

Borowiecka

Gruca

et al. 2022

J Educ Health Sport

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Introduction and purpose: Psoriasis is a skin disease that develops following chronic inflammatory signaling and keratinocyte hyperproliferation. The pathogenesis of psoriasis is compound and not yet fully understood. Several studies concerning gut microbiota composition and its role in disease pathogenesis recently demonstrated significant alterations among psoriatic patients. This study aims to highlight the latest scientific evidence regarding the gut microbiome alterations of psoriatic patients, as well as the state of knowledge in terms of microbiome-targeted therapies as promising preventive and therapeutic tools for psoriasis. Brief description of the state of knowledge: The current state of knowledge indicates that the main causes of psoriasis may be a genetic predisposition, as well as many immunological and environmental factors, including dysbiosis of the intestinal microflora. The article covers clinical and experimental studies which indicate that gut microbiota dysbiosis concerning diversity as well as the composition of the microbiome is the potential causal factor of psoriasis and the gut microbiota may serve as a promising prevention/therapy target for psoriasis patients. Conclusions: This review highlighted a strong link between psoriasis and the gut microbiota, to add new knowledge for discovering the relationship between the altered intestinal microbiota in psoriasis patients. Despite all of these interesting findings, there are a lot of limitations and challenges that future studies should face. More precise and greater studies need to be done to fully understand the potential of microbiota-aimed therapies.

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“…Response to fecal microbiota transplantation in treating irritable bowel syndrome also correlated with an increased relative abundance of Akkermansia. Reduction in the Ruminococcus , Lachnospira , and Blautia genera , as well as in the Akkermansia muciniphila species, is also reported in psoriasis [ 19 , 20 , 21 ], psoriatic arthritis, and spondyloarthritis [ 22 ], and negatively correlated with the serum levels of C3 in SLE patients [ 23 ].…”

Section: What Is the Gut Microbiome?mentioning

confidence: 99%

Role of Intestinal Dysbiosis and Nutrition in Rheumatoid Arthritis

Attur

Scher

Abramson

et al. 2022

Cells

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Rheumatoid arthritis is a chronic systemic immune-mediated disease caused by genetic and environmental factors. It is often characterized by the generation of autoantibodies that lead to synovial inflammation and eventual multi-joint destruction. A growing number of studies have shown significant differences in the gut microbiota composition of rheumatoid arthritis (RA) patients compared to healthy controls. Environmental factors, and changes in diet and nutrition are thought to play a role in developing this dysbiosis. This review aims to summarize the current knowledge of intestinal dysbiosis, the role of nutritional factors, and its implications in the pathogenesis of rheumatoid arthritis and autoimmunity. The future direction focuses on developing microbiome manipulation therapeutics for RA disease management.

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The gut microbiota profile in psoriasis: a Brazilian case-control study

Cited by 26 publications

References 29 publications

Gut Microbiota in Psoriasis

Gut Microbiota in Psoriasis

Gut Microbiome as a Novel Treatment Strategy for Psoriasis

Role of Intestinal Dysbiosis and Nutrition in Rheumatoid Arthritis

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