The healing effect of Pistacia lentiscus fruit oil on laser burn

Abstract

Context: Since antiquity, Pistacia lentiscus L. (Anacardiaceae) fruit oil (PLFO) has been used as a remedy for primary health care such as burn treatment.Objective: This study assesses the healing effect of PLFO on CO2 laser fractional burn in a rat model.Materials and methods: The study was carried out on 18 adult male Wistar rats. A second-degree laser burn (wound area = 2.2 cm2) was inflicted in the dorsal region by the application of CO2 fractional laser within the following parameters; Energy level: 25 MJ and Depth level: 4. After applying laser, the rats were divided into three groups: the first was treated with saline solution, the second with a reference cream ‘CYTOL BASIC®’ (0.13 μg/mm2) and the third with PLFO (0.52 μL/mm2). All treatments were topically administered for eight days. The healing effect was assessed using macroscopic, histological and biochemical parameters.Results: After eight days, the higher percentage of wound healing contraction was observed among the PLFO-treated group (100%) followed by the ‘CYTOL BASIC®’ treated group (61.36%) and untreated group (32.27%). During the treatment, the PLFO-treated group showed less erythema, less crusting/scabbing, higher general wound appearance scores and a high content of collagen (220.67 ± 7.48 mg/g of tissue) than the other groups.Discussion and conclusion: The current study has shown, for the first time, the healing effect of PLFO on CO2 laser fractional burn. Their wound healing effect could be attributed to their antimicrobial, anti-inflammatory and antioxidant effects.

Pistacia lentiscusL. edible oil: green extraction with bio-based solvents, metabolite profiling andin vitroanti-inflammatory activity

“…In fact, MeTHF lipid extract was mainly composed by oleic and linoleic acid (47.48 and 24.12%, respectively). These two unsaturated fatty acids have anti-inflammatory properties playing a major role in the recruitment of inflammatory cells at the inflammation site (Ben Khedir et al, 2017).…”

“…This edible oil has been used traditionally by Tunisians in their daily diet as condiment, in salads and pastries (Trabelsi et al, 2012). The Pistacia lentiscus fruit is used as a source of medicinal oil for the treatment of many diseases such as scabies, respiratory allergies and rheumatism and also for the fabrication of antidiarrhea pills (Ben Khedir et al, 2017). Recently, several studies have reported the pharmacological virtues of this fixed oil (Mezni et al, 2016;Naouar et al, 2016;Ben Khedir et al, 2017).…”

Supercritical CO2 Extraction of Extracted Oil from Pistacia lentiscus L.: Mathematical Modeling, Economic Evaluation and Scale-Up

“…Concerning yield values obtained on a pilot scale (0.30%), the cost of the manufacturing process of the supercritical extract weas between 999.63 USD/kg and 813.95 USD/kg. These values are considered very high when compared to the costs of other vegetable raw materials such as rosemary extract which is worth 49.71 USD/kg [21], ginger oleoresin which costs 99.80 USD/kg [20], Curcuma longa L. extract which is worth 164.4 USD/kg [40] and habanero pepper extract with a cost of 540.19 USD/kg [33].…”

“…In Tunisia, a species of plant called Pistacia lentiscus L., commonly known as "Dharw" in the Maghreb and "Elustaka" in the Middle East, has medicinal properties in its oil extract. The extracted oil has numerous medicianal properties, for instance anti-atherogenic [2], anti-inflammatory [3][4][5], anti-oxidant [6][7][8][9][10], antimicrobial [9,[11][12][13], hypotensive [14,15], anticancer [5,16], anti-arthritis [17], wound treatment, and anti-asthmatic and anthelmintic activities [18][19][20].…”

Potential Use of Essential Oil Isolated fromCleistocalyx operculatusLeaves as a Topical Dermatological Agent for Treatment of Burn Wound

“…The beneficial effect of Nigella sativa seed oil on burn wound healing process also was proven [ 13 ]. Furthermore, Khedir et al (2016) observed that Pistacia lentiscus fruit oil accelerated wound contraction in CO 2 laser burned wound model [ 14 ]. These findings consolidate the idea using the vegetable and vegetable oils for treating burn wound.…”