The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related Glucolipotoxicity

Abstract

This study aimed to elucidate the determinants of higher plasma malondialdehyde (MDA) in free-living adults. In a cross-sectional study we evaluated 148 free-living subjects (54 ± 11 years, 78% women) at high risk for or with metabolic syndrome (MetS). They were assessed by anthropometry and body composition, dietary intake, and clinical and laboratorial analysis. The analysis of plasma MDA was performed by HPLC, and concentration values were used to provide four groups according to percentile distribution. Subjects with higher plasma MDA showed higher prevalence of MetS and higher values of waist circumference (WC), glucose, triglycerides (TG), γ-glutamyltransferase (γ-GT), and higher energy intake. Multiadjusted logistic regression analysis identified as determinants of higher plasma MDA the altered values of WC and γ-GT followed by hypertriglyceridemia, hyperglycemia, insulin resistance, higher dietary sugar-intake, and presence of MetS. In conclusion, the glucolipotoxic state predisposed by the presence of MetS seems to be the major determinant of higher plasma MDA concentrations.

Changes in malondialdehyde and C-reactive protein concentrations after lifestyle modification are related to different metabolic syndrome-associated pathophysiological processes

“…Previous study showed that negative energy balance provided by our LiSM protocol can favor insulin sensitivity, resulting in better glucose metabolism control [35]. Although neither glucose nor MDA levels changed significantly, it was possible to observe that they have synergistically effects [36]. Controlling glucose metabolism can efficiently diminish glycation processes.…”

Aortic Pulse Wave Velocity, Ankle-Brachial Index, and Malondialdehyde in Older Adults with or without Metabolic Syndrome

“…MDA is known to generate secondary products of lipid peroxidation, reflecting the magnitude of the oxidative stress present in the organism [27]. Furthermore, the MetS prevalence was greater in participants with higher plasma MDA concentrations [28]. The mechanism that leads to a higher aPWV with increased MDA is still unclear.…”

Concentración de malondialdehido, en sujetos residentes de gran altura: estudio exploratorio

“…El MDA, producto final de la lipoperoxidación, es utilizado ampliamente como biomarcador de estrés oxidativo, en cuyo metabolismo forma malodialdehido acetaldehído (MAA), que finalmente se une a los grupos aminos de las proteínas, comportándose como proteína inmunogénica o autoanticuerpo que activa mecanismos fisiopatológicos de la ateroesclerosis, la diabetes mellitus, la preeclamsia, la enfermedad de Parkinson y la enfermedad de Alzheimer (13)(14)(15)(16)(17) .…”

“…Está definido que en un ambiente de hipoxia hipobárica, se generan mayor cantidad de RL, asimismo, se ha evidenciado el papel del estrés oxidativo en el debut de enfermedades denominadas propias de la altura, sean estas de presentación aguda o crónica, como el mal agudo de montaña y el mal crónico de montaña entre otras, asimismo, el estrés oxidativo cumple un papel importante en la génesis de enfermedades como la hipertensión arterial sistémica, la hipertensión pulmonar, la enfermedad renal, la fibrosis pulmonar, el asma, y la esclerosis lateral amiotrófica (13)(14)(15)(16) .…”