The hippocampal formation — orbitomedial prefrontal cortex circuit in the attentional control of active memory

Wall, Philip M.; Messier, Claude

doi:10.1016/s0166-4328(01)00355-2

Cited by 104 publications

(64 citation statements)

References 253 publications

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“…The observed left amygdala-anterior cingulate hyperconnectivity is also in agreement with the role assigned by theoretical and animal studies to frontolimbic connections as modulators of cognitive-emotional control of behavior (13,14) and could also be the cause of the interferences reported in functional MRI studies combining emotional and cognitive or inhibition tasks (66)(67)(68). Overall, our results support the theoretical model in which the amygdala, associated with emotional processing, is modulated by frontomedial structures controlling the complex manifestations and behavior derived from these same emotions.…”

Section: Discussionsupporting

confidence: 88%

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Converging Medial Frontal Resting State and Diffusion-Based Abnormalities in Borderline Personality Disorder

Salvador

Vega

Pascual

et al. 2016

Biological Psychiatry

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BACKGROUND: The psychological profile of patients with borderline personality disorder (BPD), with impulsivity and emotional dysregulation as core symptoms, has guided the search for abnormalities in specific brain areas such as the hippocampal-amygdala complex and the frontomedial cortex. However, whole-brain imaging studies so far have delivered highly heterogeneous results involving different brain locations. METHODS: Functional resting-state and diffusion magnetic resonance imaging data were acquired in patients with BPD and in an equal number of matched control subjects (n 5 60 for resting and n 5 43 for diffusion). While mean diffusivity and fractional anisotropy brain images were generated from diffusion data, amplitude of low-frequency fluctuations and global brain connectivity images were used for the first time to evaluate BPD-related brain abnormalities from resting functional acquisitions. RESULTS: Whole-brain analyses using a p 5 .05 corrected threshold showed a convergence of alterations in BPD patients in genual and perigenual structures, with frontal white matter fractional anisotropy abnormalities partially encircling areas of increased mean diffusivity and global brain connectivity. Additionally, a cluster of enlarged amplitude of low-frequency fluctuations (high resting activity) was found involving part of the left hippocampus and amygdala. In turn, this cluster showed increased resting functional connectivity with the anterior cingulate. CONCLUSIONS: With a multimodal approach and without using a priori selected regions, we prove that structural and functional abnormality in BPD involves both temporolimbic and frontomedial structures as well as their connectivity. These structures have been previously related to behavioral and clinical symptoms in patients with BPD.

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Section: Discussionsupporting

confidence: 88%

“…The medial frontal cortex has extensive connections with the medial temporal cortex (including the amygdala and hippocampus) ensuring the cognitive-emotional control of behavior (13). It has also been shown that the experimental disruption of these connections leads to behavioral patterns similar to those observed in individuals with BPD (14).…”

mentioning

confidence: 98%

Converging Medial Frontal Resting State and Diffusion-Based Abnormalities in Borderline Personality Disorder

Salvador

Vega

Pascual

et al. 2016

Biological Psychiatry

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“…Although gene expression studies have been reported for neonatal marmoset hippocampus using marmoset-specific DNA microarray (Datson et al, 2009), we examined molecules whose expression has not been reported in wider regions such as the entorhinal (Ent) cortex. The Ent cortex receives inputs from the cortex, especially the PFC, and projects to the hippocampus to play an important role in memory formation and consolidation (Wall and Messier, 2001). As reported previously, there are no significant gene expression differences between the mouse and marmoset CA fields and dentate gyrus (DG) (Datson et al, 2009).…”

Section: Dynamic Gene Expression In Efferent Regions Of the Pfc-hippomentioning

confidence: 99%

Comparative Anatomy of Marmoset and Mouse Cortex from Genomic Expression

et al. 2012

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Advances in mouse neural circuit genetics, brain atlases, and behavioral assays provide a powerful system for modeling the genetic basis of cognition and psychiatric disease. However, a critical limitation of this approach is how to achieve concordance of mouse neurobiology with the ultimate goal of understanding the human brain. Previously, the common marmoset has shown promise as a genetic model system toward the linking of mouse and human studies. However, the advent of marmoset transgenic approaches will require an understanding of developmental principles in marmoset compared to mouse. In this study, we used gene expression analysis in marmoset brain to pose a series of fundamental questions on cortical development and evolution for direct comparison to existing mouse brain atlas expression data. Most genes showed reliable conservation of expression between marmoset and mouse. However, certain markers had strikingly divergent expression patterns. The lateral geniculate nucleus and pulvinar in the thalamus showed diversification of genetic organization between marmoset and mouse, suggesting they share some similarity. In contrast, gene expression patterns in early visual cortical areas showed marmoset-specific expression. In prefrontal cortex, some markers labeled architectonic areas and layers distinct between mouse and marmoset. Core hippocampus was conserved, while afferent areas showed divergence. Together, these results indicate that existing cortical areas are genetically conserved between marmoset and mouse, while differences in areal parcellation, afferent diversification, and layer complexity are associated with specific genes. Collectively, we propose that gene expression patterns in marmoset brain reveal important clues to the principles underlying the molecular evolution of cortical and cognitive expansion.

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“…Modulation of synaptic activity in the connection between these two areas contributes to a synergistic regulation of learning/memory processes (Wall and Messier, 2001) and of the stress response (de Kloet et al, 2005). In fact, training in associative learning task increases synaptic transmission in the hippocampal-PFC pathway (Doyère et al, 1993) and both regions are strongly involved in the regulation of the stress response by inhibiting corticotrophin-releasing hormone (CRH) in the paraventricular hypothalamic nuclei (Sullivan and Gratton, 2002;de Kloet et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

The Prefrontal Cortex as a Key Target of the Maladaptive Response to Stress

Cerqueira¹,

Mailliet²,

Almeida³

et al. 2007

J. Neurosci.

525

426

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Research on the detrimental effects of stress in the brain has mainly focused on the hippocampus. Because prefrontal cortex (PFC) dysfunction characterizes many stress-related disorders, we here analyzed the impact of chronic stress in rats on the integrity of the hippocampal-PFC pathway, monitored by behavioral and electrophysiological function and morphological assessment. We show that chronic stress impairs synaptic plasticity by reducing LTP induction in the hippocampal-PFC connection; in addition, it induces selective atrophy within the PFC and severely disrupts working memory and behavioral flexibility, two functions that depend on PFC integrity. We also demonstrate that short periods of stress exposure induce spatial reference memory deficits before affecting PFC-dependent tasks, thus suggesting that the impairment of synaptic plasticity within the hippocampus-to-PFC connection is of relevance to the stressinduced PFC dysfunction. These findings evidence a fundamental role of the PFC in maladaptive responses to stress and identify this area as a target for intervention in stress-related disorders.

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The hippocampal formation — orbitomedial prefrontal cortex circuit in the attentional control of active memory

Cited by 104 publications

References 253 publications

Converging Medial Frontal Resting State and Diffusion-Based Abnormalities in Borderline Personality Disorder

Converging Medial Frontal Resting State and Diffusion-Based Abnormalities in Borderline Personality Disorder

Comparative Anatomy of Marmoset and Mouse Cortex from Genomic Expression

The Prefrontal Cortex as a Key Target of the Maladaptive Response to Stress

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