The histone deacetylase NlHDAC1 regulates both female and male fertility in the brown planthopper,<i>Nilaparvata lugens</i>

Zhang, Jinli; Yuan, Xiaobo; Chen, Sun-Jie; Chen, Haohao; Xu, Nan; Xue, Wenhua; Fu, Sheng-Jie; Zhang, Chuan‐Xi; Xu, Haijun

doi:10.1098/rsob.180158

Cited by 17 publications

(9 citation statements)

References 74 publications

(84 reference statements)

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“…In contrast, in solitary insects such as the pea aphid, the inhibition of histone acetylation and deacetylation affects development, fertility, and longevity (Kirfel, Kessel, Skaljac, Seip, & Vilcinskas, 2020). In fact, fertility appears to be regulated by this epigenetic mark in various taxonomic groups, which includes other insects such as the planthopper Nilaparvata lugens (Zhang et al, 2018), but also mammals including mice (Ma, Pan, Montgomery, Olson, & Schultz, 2012) and men (Wang, Gao, Li, & Liu, 2019).…”

Section: Discussionmentioning

confidence: 99%

Histone acetylation regulates the expression of genes involved in worker reproduction and lifespan in the ant Temnothorax rugatulus

Choppin

Feldmeyer

Foitzik³

2021

Preprint

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In insect societies, the queen monopolizes reproduction while workers perform tasks such as brood care or foraging. Queen loss leads to ovary development and lifespan extension in workers from many ants. However, the underlying molecular mechanisms of this phenotypic plasticity remain unclear. Recent studies highlight the importance of epigenetics in regulating plastic traits in social insects. We investigated the role of histone acetylation in the regulation of worker reproduction in the ant Temnothorax rugatulus. We removed queens from their colonies to induce worker fecundity, and either fed workers with chemical inhibitors of histone acetylation (C646), deacetylation (Trichostatin A), or the solvent (DMSO) as control. We monitored worker number for six weeks after which we assessed ovary development and sequenced fat body mRNA. Workers survived better in queenless colonies and developed their ovaries after queen removal in control colonies as expected, but not in colonies treated with chemical inhibitors. Both inhibitors affected gene expression, although the inhibition of histone acetylation using C646 influenced the expression of more genes with immunity, fecundity, and longevity functionalities. Interestingly, these C646-treated workers shared many upregulated genes with infertile workers from queenright colonies. We also identified one gene with antioxidant properties commonly downregulated in infertile workers from queenright colonies and both C646 and TSA-treated workers from queenless colonies. Our results indicate that histone acetylation is involved in the molecular regulation of worker reproduction and lifespan, and thus point to an important role of histone modifications in modulating phenotypic plasticity of life history traits in social insects.

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Section: Discussionmentioning

confidence: 99%

Histone acetylation regulates the expression of genes involved in worker reproduction and lifespan in the ant Temnothorax rugatulus

Choppin

Feldmeyer

Foitzik³

2021

Preprint

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“…Former studies have showed that silencing of the TOR gene in BPHs leads to unmatured eggs (Lu et al, 2016). The TOR nutritional signaling pathway and juvenile hormone (JH) regulation of vitellogenesis has been known for a long time (Zhai et al, 2015;Zhuo et al, 2017;Roy et al, 2018;Zhang et al, 2019). The possible involvement of NlTMC3 in TOR or JH signaling in N. lugens females needs further investigation.…”

Section: Discussionmentioning

confidence: 99%

A Mechanosensory Receptor TMC Regulates Ovary Development in the Brown Planthopper Nilaparvata lugens

et al. 2020

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Transmembrane channel-like (TMC) genes encode a family of evolutionarily conserved membrane proteins. Mutations in the TMC1 and TMC2 cause deafness in humans and mice. However, their functions in insects are is still not well known. Here we cloned three tmc genes, Nltmc3, Nltmc5, and Nltmc7 from brown planthoppers. The predicted amino acid sequences showed high identity with other species homologs and have the characteristic eight or nine transmembrane domains and TMC domain architecture. We detected these three genes in all developmental stages and examined tissues. Interestingly, we found Nltmc3 was highly expressed in the female reproductive organ especially in the oviduct. RNAi-mediated silencing of Nltmc3 substantially decreased the egg-laying number and impaired ovary development. Our results indicate that Nltmc3 has an essential role in the ovary development of brown planthoppers.

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“…Metabolic disturbances such as ketone body β-hydroxybutyrate (BOHB) has been demonstrated as an inhibitor of H3K27 and hyperacetylation [129]. Histone deacetylases (NIHDAC) play an important role in female fertility by regulating ovary maturation or ovipositor development [130]. Loss of histone acetylation inhibits chromatin accessibility and nucleosome eviction during spermiogenesis which leads to poor fertility in males [131].…”

Section: Dna Methylation and Histone Acetylationmentioning

confidence: 99%

The Role of Exosomal Epigenetic Modifiers in Cell Communication and Fertility of Dairy Cows

Abeysinghe

Turner

Garcia

et al. 2020

IJMS

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Abnormal uterine function affects conception rate and embryo development, thereby leading to poor fertility and reproduction failure. Exosomes are a nanosized subclass of extracellular vesicles (EV) that have important functions as intercellular communicators. They contain and carry transferable bioactive substances including micro RNA (miRNA) for target cells. Elements of the cargo can provide epigenetic modifications of the recipient cells and may have crucial roles in mechanisms of reproduction. The dairy industry accounts for a substantial portion of the economy of many agricultural countries. Exosomes can enhance the expression of inflammatory mediators in the endometrium, which contribute to various inflammatory diseases in transition dairy cows. This results in reduced fertility which leads to reduced milk production and increased cow maintenance costs. Thus, gaining a clear knowledge of exosomal epigenetic modifiers is critical to improving the breeding success and profitability of dairy farms. This review provides a brief overview of how exosomal miRNA contributes to inflammatory diseases and hence to poor fertility, particularly in dairy cows.

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The histone deacetylase NlHDAC1 regulates both female and male fertility in the brown planthopper,Nilaparvata lugens

Cited by 17 publications

References 74 publications

Histone acetylation regulates the expression of genes involved in worker reproduction and lifespan in the ant Temnothorax rugatulus

Histone acetylation regulates the expression of genes involved in worker reproduction and lifespan in the ant Temnothorax rugatulus

A Mechanosensory Receptor TMC Regulates Ovary Development in the Brown Planthopper Nilaparvata lugens

The Role of Exosomal Epigenetic Modifiers in Cell Communication and Fertility of Dairy Cows

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