The histopathology of cutaneous leishmaniasis in Panama

Thornburgh, David B; Johnson, Carl M.; Elton, Norman W.

doi:10.1016/0035-9203(52)90048-5

Cited by 14 publications

(11 citation statements)

References 4 publications

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“…Vasculitis is not a primary feature of C L (Jaffe, 1944;Thornburgh, et al, 1952). There was no evidence in the present study that it could have contributed significantly to the necrotising process.…”

Section: Discussioncontrasting

confidence: 77%

The evolution of the lesion in cutaneous leishmaniasis

Ridley¹,

Ridley²

1983

The Journal of Pathology

112

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In order to elucidate the mechanisms for the elimination of Leishmania, the histological evolution of the lesions of cutaneous leishmaniasis was studied in 118 biopsies from four geographical areas known to be associated with different species or sub-species of Leishmania. Basically there were 3 types of response: A, parasites were eliminated within intact macrophages which later evolved as epithelioid cells; B, they were eliminated as a result of the lysis of the macrophages either individually or in small clusters, but the process was incomplete; C, there was necrosis proceeding to completion at the centre of a focalised mass of macrophages. In B and C the release of parasites caused tissue destruction; epithelioid cells were immature and often sparse, though giant cells were seen in C. A more definite tuberculoid response was found in draining lymph nodes. The response (A, B or C) depended partly on the parasite load, partly on geographical factors. The relative proportions of macrophages, plasma cells and lymphocytes in the lesions varied with the parasite index, but the relationship was the same in all 3 types of response. This suggested that the 3 responses might be the outcome of a common immunological mechanism operating at different antigen levels or antigen-antibody ratios.

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Section: Discussioncontrasting

confidence: 77%

The evolution of the lesion in cutaneous leishmaniasis

Ridley¹,

Ridley²

1983

The Journal of Pathology

112

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“…Chronic nonspecific and/or granulomatous inflammation are the main histopathological manifestations of cutaneous and mucocutaneous leishmaniasis in the New World 9 , 39 . The associated infiltration of plasma cells and vascular alterations are suggestive but not diagnostic features of the disease 20 , 37 , 39 . The specific diagnosis is only possible through the demonstration of parasites in examined tissues 29 .…”

Section: Discussionmentioning

confidence: 95%

“…On the other hand, it is common to send histological samples of patients with suspected CL lesions to pathology units of reference Panamanian health institutions in which pathologists must have previous experience and academic background. However, studies aimed to characterize CL histopathological findings in Panama are scarce and consequently necessary for the diagnostic and prognostic support of these parasitic infections that are so frequent in this country 20 .…”

Section: Discussionmentioning

confidence: 99%

“…Fox in 1931 18 summarized the clinical and gross features of the disease as seen in Brazil, but did not stress the histological aspects, which were later summarized by Snow et al in 1948 19 . However, there is only one detailed report from 1952 describing the histopathological changes in skin lesions of patients affected by CL in Panamá 20 . The results showed a rather constant and distinctive histological pattern presented in 20 skin ulcer biopsies due to CL.…”

Section: Introductionmentioning

confidence: 99%

“…The results showed a rather constant and distinctive histological pattern presented in 20 skin ulcer biopsies due to CL. The cardinal findings of epithelial hyperplasia, poor granulation, intense chronic inflammation of the dermal papillae, inflammatory cells located on sweat glands towards the periphery of the lesion, and lack of blood vessel changes, differentiate leishmaniasis from most cutaneous ulcers; however, positive diagnosis still requires the demonstration of the presence of parasites 20 .…”

Section: Introductionmentioning

confidence: 99%

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Histopathological characteristics of cutaneous lesions caused by Leishmania Viannia panamensis in Panama

González

Diaz

Ferreira

et al. 2018

Rev. Inst. Med. trop. S. Paulo

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Cutaneous leishmaniasis (CL) is an endemic disease in the Republic of Panama, caused by Leishmania (Viannia) parasites, whose most common clinical manifestation is the presence of ulcerated lesions on the skin. These lesions usually present a chronic inflammatory reaction, sometimes granulomatous, with the presence of lymphocytes, plasma cells and macrophages. This study describes the histopathological characteristics found in the skin lesions of patients with CL caused by Leishmania (V.) panamensis in Panama. We analyzed 49 skin biopsy samples from patients with clinical suspicion of CL, by molecular tests (PCR for subgenus Viannia and HSP-70) and by Hematoxylin-Eosin staining. Samples were characterized at the species level by PCR-HSP-70/RFLP. From the 49 samples studied, 46 (94%) were positive by PCR and were characterized as Leishmania (V.) panamensis. Of these, 48% were positive by Hematoxylin-Eosin staining with alterations being observed both, in the epidermis (85%) and in the dermis (100%) of skin biopsies. The inflammatory infiltrate was characterized according to histopathological patterns: lymphohistiocytic (50%), lymphoplasmacytic (61%) and granulomatous (46%) infiltration, being the combination of these patterns frequently found. The predominant histopathological characteristics observed in CL lesions caused by L. (V.) panamensis in Panama were: an intense inflammatory reaction in the dermis with a combination of lymphohistiocytic, lymphoplasmacytic and granulomatous presentation patterns and the presence of ulcers, acanthosis, exocytosis and spongiosis in the epidermis.

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Histopathology of Cutaneous Leishmaniasis

Kurban¹

1966

Arch Dermatol

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The histopathology of cutaneous leishmaniasis in Panama

Cited by 14 publications

References 4 publications

The evolution of the lesion in cutaneous leishmaniasis

The evolution of the lesion in cutaneous leishmaniasis

Histopathological characteristics of cutaneous lesions caused by Leishmania Viannia panamensis in Panama

Histopathology of Cutaneous Leishmaniasis

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