The human dorsal hippocampal commissure: Delineating connections across the midline using multi-modal neuroimaging in major depressive disorder

Nasa, Anurag; Gaughan, Caoimhe; Mahmoud, Muhammad; Kelly, John R.; Román, Elena; Levins, Kirk J.; Barry, Denis; Frodl, Thomas; O’Hanlon, Erik; O’Keane, Veronica; Roddy, Darren William

doi:10.1016/j.ynirp.2021.100062

Cited by 4 publications

(2 citation statements)

References 66 publications

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“…It is established that the limbic system and specifically the amygdala (104,105) are important transdiagnostic nodes in the therapeutic modulation of negative-positive valence systems. Hyper-reactivity of the amygdala is associated with negative processing/affectivity and an attentional bias to negative valenced information, which can occur across a range of stress related disorders, such as depression and various anxiety disorders (106)(107)(108)(109).…”

Section: Lossmentioning

confidence: 99%

Psychedelic Therapy's Transdiagnostic Effects: A Research Domain Criteria (RDoC) Perspective

et al. 2021

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Accumulating clinical evidence shows that psychedelic therapy, by synergistically combining psychopharmacology and psychological support, offers a promising transdiagnostic treatment strategy for a range of disorders with restricted and/or maladaptive habitual patterns of emotion, cognition and behavior, notably, depression (MDD), treatment resistant depression (TRD) and addiction disorders, but perhaps also anxiety disorders, obsessive-compulsive disorder (OCD), Post-Traumatic Stress Disorder (PTSD) and eating disorders. Despite the emergent transdiagnostic evidence, the specific clinical dimensions that psychedelics are efficacious for, and associated underlying neurobiological pathways, remain to be well-characterized. To this end, this review focuses on pre-clinical and clinical evidence of the acute and sustained therapeutic potential of psychedelic therapy in the context of a transdiagnostic dimensional systems framework. Focusing on the Research Domain Criteria (RDoC) as a template, we will describe the multimodal mechanisms underlying the transdiagnostic therapeutic effects of psychedelic therapy, traversing molecular, cellular and network levels. These levels will be mapped to the RDoC constructs of negative and positive valence systems, arousal regulation, social processing, cognitive and sensorimotor systems. In summarizing this literature and framing it transdiagnostically, we hope we can assist the field in moving toward a mechanistic understanding of how psychedelics work for patients and eventually toward a precise-personalized psychedelic therapy paradigm.

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Section: Lossmentioning

confidence: 99%

Psychedelic Therapy's Transdiagnostic Effects: A Research Domain Criteria (RDoC) Perspective

et al. 2021

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“…The hippocampus, a key temporal structure involved in memory and spatial awareness, has been found to be disturbed in many psychiatric conditions (Nolan et al, 2020; Roddy & O'Keane, 2019) including early psychosis (Calvo et al, 2020). Major connections from the hippocampus to the rest of the limbic system include the fornix, dorsal hippocampal commissure (Nasa et al, 2021) and cingulum. This bundle extends from the posterior hippocampus over the corpus callosum to the prefrontal cortex.…”

Section: Introductionmentioning

confidence: 99%

Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along‐tract analysis

Roddy

Román

Nasa

et al. 2022

Eur J of Neuroscience

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Psychotic experiences (PEs) such as hallucinations and delusions are common among young people without psychiatric diagnoses and are associated with connectivity and white matter abnormalities, particularly in the limbic system. Using diffusion magnetic resonance imaging (MRI) in adolescents with reported PEs and matched controls, we examined the cingulum white matter tract along its length rather than as the usually reported single indivisible structure. Complex regional differences in diffusion metrics were found along the bundle at key loci following Bonferroni significance adjustment (p < .00013) with moderate to large effect sizes (.11-.76) throughout all significant subsegments. In this prospective community-based cohort of school-age children, these findings suggest that white matter alterations in the limbic system may be more common in the general non-clinical adolescent population than previously thought. Such white matter alternations may only be uncovered using a similar more granular along-tract analysis of white matter tracts. K E Y W O R D Salong-tract analysis, cingulum, psychosis, psychotic experiences, tractography | INTRODUCTIONPsychosis, a common feature of many psychiatric, neurological and medical conditions, incorporates core symptoms of reality testing including delusions, hallucinations and thought disorders (American Psychiatric Association, 2013). Recently, the existence of an extended psychosis phenotype has been proposed suggesting that

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Sex difference in brain functional connectivity of hippocampus in Alzheimer’s disease

Williamson,

James,

Mukli

et al. 2023

GeroScience

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The human dorsal hippocampal commissure: Delineating connections across the midline using multi-modal neuroimaging in major depressive disorder

Cited by 4 publications

References 66 publications

Psychedelic Therapy's Transdiagnostic Effects: A Research Domain Criteria (RDoC) Perspective

Psychedelic Therapy's Transdiagnostic Effects: A Research Domain Criteria (RDoC) Perspective

Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along‐tract analysis

Sex difference in brain functional connectivity of hippocampus in Alzheimer’s disease

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