The hyaluronate receptor is preferentially expressed on proliferating epithelial cells.

Abstract

Abstract. In the present study, we have examined the distribution of the hyaluronate receptor as well as hyaluronate itself in a variety of adult tissues. The hyaluronate receptor was localized with a monoclonal antibody, termed K-3, while hyaluronate was localized using proteolytic fragments of cartilage proteoglycan. Staining with the K-3 monoclonal antibody revealed that the hyaluronate receptor was present in a variety of epithelia including the skin, cheek, tongue, esophagus, vagina, intestines, oviduct, and bladder. However, it was notably absent from epithelial cells of the cornea and stomach as well as from endothelial cells of blood vessels. When present, the hyaluronate receptor was preferentially located in regions of active cell growth, such as in the basal layers of stratified epithelium and at the base of the crypts of Lieberkuhn in intestinal epithelium. A similar phenomenon was observed in cultured 3T3 cells. Cultures of 3T3 cells that were actively proliferating were found to have greater amounts of the receptor than their nonproliferating counterparts. When the various tissues were examined for hyaluronate, it was found to have a widespread distribution, being present in most of the basement membranes and between the cells in stratified epithelium. Indeed, in many cases, the distribution of hyaluronate closely paralleled that of the hyaluronate receptor. These results suggest that the interaction between hyaluronate and its receptor is involved in cell-tosubstratum adhesion.

CD44 binds to the Shigella IpaB protein and participates in bacterial invasion of epithelial cells

“…Association of IpaB with these receptors could therefore explain the polarity of the entry process, which is essentially basolateral . Such interactions could also explain the preferential tropism of Shigella in vivo (Perdomo et al, 1994), as CD44 displays a basolateral distribution, particularly in the immature cells of intestinal crypts (Alho and Underhill, 1989).…”

Relationship of Cytokeratin 20 and CD44 Protein Expression with WHO/ISUP Grade in pTa and pT1 Papillary Urothelial Neoplasia

“…Alho and Underhill (44) have shown that CD44 is expressed on a variety of different epithelia in vivo but that it is particularly noted in rapidly proliferating cells, which may have a crucial role in epithelial maturation. We have also observed an accentuated staining pattern of CD44 IR observed in reactive (45) and highly proliferative urothelium, associated with previous therapy (45).…”

Efecto del hialuronato de zinc sobre las úlceras en pacientes con diabetes

“…Sin embargo, los niveles de áci-do hialurónico se elevan en forma dramática inmediatamente después de la lesión tisular (10). El ácido hialurónico puede estar unido a receptores que están preferentemente localizados en regiones de crecimiento celular activo (11).…”