The hydrogel of whey protein isolate coated by lotus root amylopectin enhance the stability and bioavailability of quercetin

Liu, Kang; Zha, Xue‐Qiang; Shen, Wen‐Di; Li, Qiang-Ming; Pan, Li‐Hua; Luo, Jian‐Ping

doi:10.1016/j.carbpol.2020.116009

Cited by 55 publications

(32 citation statements)

References 40 publications

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“…The similar retention of quercetin in HZ and HZchi/pec particles (Figure 10A) indicates that the protection was fundamentally attributed to zein. A comparable protective effect has previously been reported by encapsulating quercetin in WPI/lotus root amylopectin, pea protein-isolated and zein/soluble soybean polysaccharide composite nanoparticles due to hydrogen and hydrophobic interaction between quercetin and proteins [39,43,64].…”

Section: Photochemical Stabilitysupporting

confidence: 78%

“…The distinct peaks of quercetin with lower intensities were apparent in its mixture of zein, chitosan and pectin. In the diffractograms of qHZ, qHZ-chi and qHZ-chi/pec particles, the crystalline peaks of quercetin disappeared, advocating the transformation from crystalline to an amorous state upon encapsulation in particles [ 10 , 39 ]. Pure zein and chitosan showed mild crystallinity with moderate peaks at 9.56 and 20.24 2θ because of respective α-helixes and crystal lattice structure [ 40 , 41 ].…”

Section: Resultsmentioning

confidence: 99%

“…Liu and coworkers reported a drastic decrease in the content of quercetin to around 38% in 3 days of storage at room temperature [ 39 ]. The degradation of quercetin was faster at 45 °C than 25 °C, with the retention of quercetin being 42% and 16% after 2 days ( Figure 10 B), respectively.…”

Section: Resultsmentioning

confidence: 99%

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Improving Physicochemical Stability of Quercetin-Loaded Hollow Zein Particles with Chitosan/Pectin Complex Coating

et al. 2021

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Hollow nanoparticles are preferred over solid ones for their high loading capabilities, sustained release and low density. Hollow zein particles are susceptible to aggregation with a slight variation in the ionic strength, pH and temperature of the medium. This study was aimed to fabricate quercetin-loaded hollow zein particles with chitosan and pectin coating to improve their physicochemical stability. Quercetin as a model flavonoid had a loading efficiency and capacity of about 86–94% and 2.22–5.89%, respectively. Infrared and X-ray diffraction investigations revealed the interaction of quercetin with zein and the change in its physical state from crystalline to amorphous upon incorporation in the composite particles. The chitosan/pectin coating improved the stability of quercetin-loaded hollow zein particles against heat treatment, sodium chloride and in a wide range of pH. The complex coating protected quercetin that was encapsulated in hollow zein particles from free radicals in the aqueous medium and enhanced its DPPH radical scavenging ability. The entrapment of quercetin in the particles improved its storage and photochemical stability. The storage stability of entrapped quercetin was enhanced both at 25 and 45 °C in hollow zein particles coated with chitosan and pectin. Therefore, composite hollow zein particles fabricated with a combination of polysaccharides can expand their role in the encapsulation, protection and delivery of bioactive components.

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Section: Photochemical Stabilitysupporting

confidence: 78%

Section: Resultsmentioning

confidence: 99%

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Improving Physicochemical Stability of Quercetin-Loaded Hollow Zein Particles with Chitosan/Pectin Complex Coating

et al. 2021

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“…The higher value in the plasma of mice gavage with PWPC-GSH than that of free GSH group may be due to the protection effect of highly viscous PWPC [39,40] by embedding GSH inside and preventing damage to gastrointestinal enzymes and an acidic environment. These results were consistent with previous studies that the bioavailability of quercetin and vitamin D were improved through whey protein encapsulating [41,42]. Pharmacokinetic parameters were calculated as shown in inset of Figure 3A.…”

Section: In Vivo Pharmacokinetic and Antioxidant Activity Of Pwpc-gshsupporting

confidence: 91%

Polymerized Whey Protein Concentrate-Based Glutathione Delivery System: Physicochemical Characterization, Bioavailability and Sub-Chronic Toxicity Evaluation

et al. 2021

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Glutathione (GSH) is a powerful antioxidant, but its application is limited due to poor storage stability and low bioavailability. A novel nutrient encapsulation and delivery system, consisting of polymerized whey protein concentrate and GSH, was prepared and in vivo bioavailability, antioxidant capacity and toxicity were evaluated. Polymerized whey protein concentrate encapsulated GSH (PWPC-GSH) showed a diameter of roughly 1115 ± 7.07 nm (D50) and zeta potential of 30.37 ± 0.75 mV. Differential scanning calorimetry (DSC) confirmed that GSH was successfully dispersed in PWPC particles. In vivo pharmacokinetics study suggested that PWPC-GSH displayed 2.5-times and 2.6-fold enhancement in maximum concentration (Cmax) and area under the concentration–time curve (AUC) as compared to free GSH. Additionally, compared with plasma of mice gavage with free GSH, significantly increased antioxidant capacity of plasma in mice with PWPC-GSH was observed (p < 0.05). Sub-chronic toxicity evaluation indicated that no adverse toxicological reactions related to oral administration of PWPC-GSH were observed on male and female rats with a diet containing PWPC-GSH up to 4% (w/w). Data indicated that PWPC may be an effective carrier for GSH to improve bioavailability and antioxidant capacity.

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“…This large group of polyphenolics is responsible for the antioxidant activities which play a vital role in restraining oxidative stress and healing a range of diseases. for the aromatic bending and the stretching vibration (Liu et al, 2020).…”

Section: Chemical Derivatizationmentioning

confidence: 99%

High‐performance thin‐layer chromatography based approach for bioassay and ATR–FTIR spectroscopy for the evaluation of antioxidant compounds from Asparagus racemosus Willd. aerial parts

Ashraf

Das

Dua

et al. 2021

Biomedical Chromatography

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Asparagus racemosus Willd. is widely used to combat various diseases owing to its medicinal properties. In this study, arial parts of A. racemosus were investigated for their total phenolic content, total flavonoid content and antioxidative potential. A high-performance thin-layer chromatography (HPTLC) method combined with effect-directed-analysis was also developed to screen the antioxidant effects of A. racemosus and quantify biologically active compounds on chromatograms from A. racemosus. Total phenolics (154 mg gallic acid equivalent/g), flavonoid contents (497 mg quercetin/g) and IC 50 (15.25 μg/ml) were found to be higher in methanolic extract of A. racemosus than in n-hexane, chloroform and ethyl acetate extracts.HPTLC hyphenated with chemical derivatizations (DPPH•, p-anisaldehyde/sulfuric acid, and ferric chloride) was used to evaluate antioxidant activity and the presence of phytosterols, terpenoids and polyphenolic contents. The same compounds at 100*retention factor = 58, 68, 74 and 65 in extracts were responsible for antioxidant activity. Hyphenated HPTLC allowed a rapid characterization of the active compound with a combination of effect-directed-analysis and attenuated total reflectance-Fourier transform infrared spectroscopy. Spectral analysis of the band from attenuated total reflectance identified myricetin, quercetin, p-coumaric acid and caffeic acid as responsible for the antioxidant activity.

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The hydrogel of whey protein isolate coated by lotus root amylopectin enhance the stability and bioavailability of quercetin

Cited by 55 publications

References 40 publications

Improving Physicochemical Stability of Quercetin-Loaded Hollow Zein Particles with Chitosan/Pectin Complex Coating

Improving Physicochemical Stability of Quercetin-Loaded Hollow Zein Particles with Chitosan/Pectin Complex Coating

Polymerized Whey Protein Concentrate-Based Glutathione Delivery System: Physicochemical Characterization, Bioavailability and Sub-Chronic Toxicity Evaluation

High‐performance thin‐layer chromatography based approach for bioassay and ATR–FTIR spectroscopy for the evaluation of antioxidant compounds from Asparagus racemosus Willd. aerial parts

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