The hydrophobic expansion of erythrocyte membranes by the phenol anesthetics

Machleidt, Hans; Roth, Sheldon H.; Seeman, Philip

doi:10.1016/0005-2736(72)90020-x

Cited by 62 publications

(12 citation statements)

References 15 publications

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“…That is, the anesthetic-membrane interaction is fundamentally of a hydrophobic character. A consequence of this type of interaction is the known influence of the lipid solubility of several neutral anesthetic molecules on their membrane activity (9,15). In our bacterial system we found a clear correlation between the activity of the four local anesthetics studied and their lipid solubilities (in terms of their octanol-water partition coefficients).…”

Section: Discussionmentioning

confidence: 99%

Effects of local anesthetics on bacterial cells

Silva¹,

Sousa²,

Polonia³

et al. 1979

J Bacteriol

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Section: Discussionmentioning

confidence: 99%

Effects of local anesthetics on bacterial cells

Silva¹,

Sousa²,

Polonia³

et al. 1979

J Bacteriol

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“…The high degree of ordering of solutes in a lipid bilayer compared with a bulk liquid phase also significantly changes the thermodynamics of the partitioning (280,348). Nevertheless, a good correlation between the partition coefficient of various lipophilic compounds in membrane/buffer and octanol/water two-phase systems has been observed (186,275) (Fig. 3).…”

Section: Partitioning Of Solutes Into the Membranementioning

confidence: 98%

Mechanisms of membrane toxicity of hydrocarbons.

Sikkema

Bont

Poolman

1995

Microbiological Reviews

1,545

740

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“…The most extensive previous study of K's in membrane suspensions is that of Seeman, Roth and co-workers, based on methods developed by Metcalfe, Seeman and Burgen (t968), Kwant and Seeman (1969), and Seeman, Roth and Schneider (1971), and further used by Seeman (1969), Machleidt, Roth and Seeman (1972), Roth, Seeman, Akerman and ChauWong (1972), and . These workers applied their method to the determination of K's in three types of biological membranes (erythrocytes, synaptosomes and sarcoplasmic reticulum).…”

Section: Comparison With Other Studiesmentioning

confidence: 99%

A method for measuring nonelectrolyte partition coefficients between liposomes and water

Katz

Diamond

1974

J. Membrain Biol.

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Summary. This series of papers describes methods for measuring solute partition coefficients between membrane suspensions and water, and applies these methods to the system dimyristoyl lecithin:water. Knowledge of partition coefficients is relevant to analyzing permeability coefficients, probing membrane structure, and evaluating permeation models. The theoretical section of this first paper derives equations to correct measured partition coefficients for the effects of trapped water in the precipitate, tritium exchange with lipids or membranes, and nonsolvent water adjacent to membranes. The experimental section presents methods for measuring partition coefficients in liposomes of dimyristoyl lecithin, including techniques for minimizing effects of counter drift and quenching on double-label radioactive counting. These methods offer advantages in measuring membrane:water partition coefficients that are not high.A partition coefficient (K) is the ratio, at equilibrium, of a solute's concentrations in two immiscible phases between which solute can migrate. In the present series of papers we describe methods for measuring nonelectrolyte partition coefficients between membrane suspensions and water, and we apply these methods to aqueous suspensions of dimyristoyl lecithin liposomes. The methods should also be appficable to determining partition coefficients between biological membranes and water.These measurements are relevant to at least three general problems in membrane biology. First, the solute permeability coefficient (P), as commonly measured in biological membranes, is a black-box quantity which actually depends upon the solute's membrane:water K, the solute's diffusion coefficient within the membrane D, the membrane thickness Xo, and the resistances r' and r" of the two membrane:water interfaces to the * These papers are dedicated to the memory of Aharon Katchalsky, admired teacher and friend.

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The hydrophobic expansion of erythrocyte membranes by the phenol anesthetics

Cited by 62 publications

References 15 publications

Effects of local anesthetics on bacterial cells

Effects of local anesthetics on bacterial cells

Mechanisms of membrane toxicity of hydrocarbons.

A method for measuring nonelectrolyte partition coefficients between liposomes and water

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