The hypocholesterolemic activity of Momordica charantia fruit is mediated by the altered cholesterol- and bile acid–regulating gene expression in rat liver

Matsui, Sho; Yamane, Takumi; Takita, Toshichika; Oishi, Yoshifumi; Kobayashi‐Hattori, Kazuo

doi:10.1016/j.nutres.2013.05.002

Cited by 36 publications

(23 citation statements)

References 21 publications

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“…Bile obstruction due to cholestasis, or secretion and/or ingestion impairment of hepatocytes, increases the serum TBA. A previous study has confirmed that serum bile acid is specific, sensitive and stable during liver functional changes (16). In the present study, serum TBA was negatively associated with serum HA and was statistically significant.…”

Section: Discussionsupporting

confidence: 85%

Correlation analysis between four serum biomarkers of liver fibrosis and liver function in infants with cholestasis

et al. 2016

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Section: Discussionsupporting

confidence: 85%

Correlation analysis between four serum biomarkers of liver fibrosis and liver function in infants with cholestasis

et al. 2016

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“…Activated FXR stimulated expression of SHP, which integrated with the liver receptor homolog and inhibited transcription of CYP7A1 (31,32). Bile acid is known to be a regulator of cysteine sulfinic acid decarboxylase via mechanisms shared in part with CYP7A1, and may affect cholesterol via CYP7A1 through the downregulation of the hepatic FXR/SHP pathway (33,34). Bile acid levels were shown to be increased with an increased expression of BSEP and the expression of NTCP and ASBT are also known to be involved in the regulation of bile acid metabolism (35,36,37).…”

Section: Discussionmentioning

confidence: 99%

Bile acid promotes liver regeneration via farnesoid X receptor signaling pathways in rats

Ding

Yang

et al. 2015

Molecular Medicine Reports

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Abstract. Bile acids, which are synthesized from cholesterol in the hepatocytes of the liver, are amphipathic molecules with a steroid backbone. Studies have shown that bile acid exhibits important effects on liver regeneration. However, the mechanism underlying these effects remains unclear. The aim of the present study was to investigate the effect of bile acid and the farnesoid X receptor (FXR) on hepatic regeneration and lipid metabolism. Rats were fed with 0.2% bile acid or glucose for 7 days and then subjected to a 50 or 70% hepatectomy. Hepatic regeneration rate, serum and liver levels of bile acid, and expression of FXR and Caveolin-1, were detected at 24, 48 or 72 h following hepatectomy. The expression of proliferating cell nuclear antigen (PCNA) in the liver was measured using immunohistochemistry at the end of the study. Hepatocytes isolated from rats were treated with bile acid, glucose, FXR agonist and FXR antagonist, separately or in combination. Lipid metabolism, the expression of members of the FXR signaling pathway and energy metabolism-related factors were measured using ELISA kits or western blotting. Bile acid significantly increased the hepatic regeneration rate and the expression of FXR, Caveolin-1 and PCNA. Levels of total cholesterol and high density lipoprotein were increased in bile acid-or FXR agonist-treated hepatocytes in vitro. Levels of triglyceride, low density lipoprotein and free fatty acid were decreased. In addition, bile acid and FXR agonists increased the expression of bile salt export pump and small heterodimer partner, and downregulated the expression of apical sodium-dependent bile acid transporter, Na + /taurocholate cotransporting polypeptide and cholesterol 7α-hydroxylase. These results suggested that physiological concentrations of bile acid may promote liver regeneration via FXR signaling pathways, and may be associated with energy metabolism. IntroductionLiver regeneration is important in the recovery from injury induced by surgery, trauma, poisoning, infection, necrosis or liver transplantation (1). Consequently, research investigating the improvement of the regeneration ability of the liver, is of great significance. During regeneration, quiescent mature hepatocytes reenter the cell cycle in order to proliferate and divide, thus leading to hepatic regeneration without the involvement of stem cells. Although the exact mechanisms have not been fully characterized, a study demonstrated that liver regeneration primarily comprises cell proliferation, lipid metabolism, various growth factors, and a number of cytokines and their signaling pathways (2).Bile acid, which is synthesized from cholesterol, is the chief components of bile. The primary functions of bile are to digest the fat soluble molecules in food and to aid in the intestinal absorption of lipids in vivo. Recent studies have shown that bile acid acts as a signaling molecule by activating signaling pathways, and that it participates in the process of liver regeneration (3,4). A number of transport proteins fo...

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“…Many other medicinal plants showed hypocholesterolemic activity, such as leaf extracts of lupeol and lupeol linoleate [119], Averrhoa bilimbi fruit [120], Cistanche tubulosa extract [121], spirulina [122], peanuts [123], Cnidoscolus chayamansa [124], aqueous ginger (Zingiber officinale) [125], Citrus bergamia Risso and Poiteau juice [126], Momordica charantia fruit [127], cocoa products [128], garlic [129], aç a ı (Euterpe oleracea Mart.) [130], citrus peel [131], Lycium ruthenicum anthocyanins [132], arti choke leaf extract [133], Ficus microcarpa (L.) [134], grape juice [135], Ficus racemosa [136], and Hibiscus sabadariffa extract [137].…”

Section: Miscellaneous Medicinal Plantsmentioning

confidence: 99%

Cholesterol overload impairing cerebellar function: The promise of natural products

El‐Sayyad

2015

Nutrition

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The hypocholesterolemic activity of Momordica charantia fruit is mediated by the altered cholesterol- and bile acid–regulating gene expression in rat liver

Cited by 36 publications

References 21 publications

Correlation analysis between four serum biomarkers of liver fibrosis and liver function in infants with cholestasis

Correlation analysis between four serum biomarkers of liver fibrosis and liver function in infants with cholestasis

Bile acid promotes liver regeneration via farnesoid X receptor signaling pathways in rats

Cholesterol overload impairing cerebellar function: The promise of natural products

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