The Hypocholesterolemic and Antioxidative Effect of Dietary Diosgenin and Chromium Chloride Supplementation on High-Cholesterol Fed Japanese Quails

Al-Matubsi, Hisham Y.; Nasrat, Nagham A; Oriquat, Ghaleb A.; Abu-Samak, Mahmoud; Al-Mzain, Khtan A; Salim, M.

doi:10.3923/pjbs.2011.425.432

Cited by 16 publications

(10 citation statements)

References 19 publications

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“…At week 4, pronounced effect on HDL cholesterol level increment was found in the group of rats treated by crude diosgenin extract from purple greater yam (p < 0.05). Similar findings were reported by Al-Matubsi et al (2011) andSalimeh et al (2011) that dietary diosgenin increased HDL cholesterol. Son et al (2007) showed that supplementation of 0.5% diosgenin in a high cholesterol diet increased serum HDL cholesterol levels by 1.5-fold compared to controls.…”

Section: Blood Serum Lipid Profilesupporting

confidence: 90%

The Effect of Crude Diosgenin Extract from Purple and Yellow Greater Yams (Dioscorea alata L.) on the Lipid Profile of Dyslipidemia Rats

Harijono

Estiasih

Ariestiningsih

et al. 2016

Emir. J. Food Agric

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Section: Blood Serum Lipid Profilesupporting

confidence: 90%

The Effect of Crude Diosgenin Extract from Purple and Yellow Greater Yams (Dioscorea alata L.) on the Lipid Profile of Dyslipidemia Rats

Harijono

Estiasih

Ariestiningsih

et al. 2016

Emir. J. Food Agric

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“…Number of studies has shown that steroid saponin extracted from fenugreek seeds has the ability to modify cholesterol status by its capacity to bind both cholesterol and bile acids [41]. Diosgenin, a steroidal sapogenin extracted from fenugreek seeds, has in fact been shown to reduce TC as well as LDL-C in high-cholesterol fed quails [42]. On the other hand, trigonelline, an alkaloid isolated from fenugreek seeds, was found able to normalize the rate of lipogenesis in streptozotocin induced hyperglycemic rats by stimulating hepatic lipogenic enzymes [43].…”

Section: Discussionmentioning

confidence: 99%

Study of lipid profile and parieto-temporal lipid peroxidation in AlCl3 mediated neurotoxicity. modulatory effect of fenugreek seeds

et al. 2012

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BackgroundPeroxidation of lipid (LPO) membrane and cholesterol metabolism have been involved in the physiopathology of many diseases of aging brain. Therefore, this prospective animal study was carried firstly to find out the correlation between LPO in posterior brain and plasmatic cholesterol along with lipoprotein levels after chronic intoxication by aluminium chloride (AlCl3). Chronic aluminum-induced neurotoxicity has been in fact related to enhanced brain lipid peroxidation together with hypercholesterolemia and hypertriglyceridemia, despite its controversial etiological role in neurodegenerative diseases. Secondly an evaluation of the effectiveness of fenugreek seeds in alleviating the engendered toxicity through these biochemical parameters was made.ResultsOral administration of AlCl3 to rats during 5 months (500 mg/kg bw i.g for one month then 1600 ppm via the drinking water) enhanced the levels of LPO in posterior brain, liver and plasma together with lactate dehydrogenase (LDH) activities, total cholesterol (TC), triglycerides (TG) and LDL-C (Low Density Lipoproteins) levels. All these parameters were decreased following fenugreek seeds supplementation either as fenugreek seed powder (FSP) or fenugreek seed extract (FSE). A notable significant correlation was observed between LPObrain and LDL-C on one hand and LDHliver on the other hand. This latter was found to correlate positively with TC, TG and LDL-C. Furthermore, high significant correlations were observed between LDHbrain and TC, TG, LDL-C, LPObrain as well as LDHliver.ConclusionAluminium-induced LPO in brain could arise from alteration of lipid metabolism particularly altered lipoprotein metabolism rather than a direct effect of cholesterol oxidation. Fenugreek seeds could play an anti-peroxidative role in brain which may be attributed in part to its modulatory effect on plasmatic lipid metabolism.

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“…Additionally, it is also used in synthesis of steroid like estrogens and DHEA [1]. Several preclinical studies have implicated the potential use of diosgenin in several ailments like cancer, diabetes, hypercholesterolemia, gastrointestinal disorders, and inflammatory conditions [2][3][4][5]. In addition, diosgenin and dioscin have been reported to show antifungal properties [6].…”

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confidence: 99%

Characterization of in Vitro ADME Properties of Diosgenin and Dioscin from Dioscorea villosa

et al. 2013

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Dioscorea villosa (wild yam) is native to North America and has been widely used as a natural alternative for estrogen replacement therapy to improve women’s health as well as to treat inflammation, muscle spasm, and asthma. Diosgenin and dioscin (glycoside form of diosgenin) are reported to be the pharmacologically active compounds. Despite the reports of significant pharmacological properties of dioscin and diosgenin in conditions related to inflammation, cancer, diabetes, and gastrointestinal ailments, no reports are available on ADME properties of these compounds. This study was carried out to determine ADME properties of diosgenin and dioscin and their effects on major drug metabolizing enzymes (CYP 3A4, 2D6, 2C9, and 1A2). The stability was determined in simulated gastric and intestinal fluids (SGF, pH 1.2 and SIF, pH 6.8), and intestinal transport was evaluated in Caco-2 model. Phase I and phase II metabolic stability was determined in human liver microsomes and S9 fractions, respectively. Quantitative analysis of dioscin and diosgenin was performed by UPLC-MS system. Dioscin degraded up to 28.3% in SGF and 12.4% in SIF, which could be accounted for by its conversion to diosgenin (24.2%. in SGF and 2.4% in SIF). The depletion of diosgenin in SGF and SIF was < 10%. Diosgenin was stable in HLM but disappeared in S9 fraction with a half-life of 11.3 min. In contrast, dioscin was stable in both HLM and S9 fractions. Dioscin showed higher permeability across Caco-2 monolayer with no significant efflux, while diosgenin was subjected to efflux mediated by P-glycoprotein. Diosgenin and dioscin inhibited CYP3A4 with IC50 values of 17 and 33 μM, respectively, while other CYP enzymes were not affected. In conclusion, dioscin showed better intestinal permeability. Conversion of dioscin to diosgenin was observed in both gastric and intestinal fluids. No phase I metabolism was detected for both compounds. The disappearance of diosgenin in S9 fraction indicated phase II metabolism.

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The Hypocholesterolemic and Antioxidative Effect of Dietary Diosgenin and Chromium Chloride Supplementation on High-Cholesterol Fed Japanese Quails

Cited by 16 publications

References 19 publications

The Effect of Crude Diosgenin Extract from Purple and Yellow Greater Yams (Dioscorea alata L.) on the Lipid Profile of Dyslipidemia Rats

The Effect of Crude Diosgenin Extract from Purple and Yellow Greater Yams (Dioscorea alata L.) on the Lipid Profile of Dyslipidemia Rats

Study of lipid profile and parieto-temporal lipid peroxidation in AlCl3 mediated neurotoxicity. modulatory effect of fenugreek seeds

Characterization of in Vitro ADME Properties of Diosgenin and Dioscin from Dioscorea villosa

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