The Hypothalamic-Pituitary-Adrenal Axis, Obesity, and Chronic Stress Exposure: Sleep and the HPA Axis in Obesity

Lucassen, Eliane A.; Cizza, Giovanni

doi:10.1007/s13679-012-0028-5

Cited by 74 publications

(40 citation statements)

References 49 publications

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“…Importantly, the concentration of cortisol in saliva is independent of the salivary flow rate and is strongly correlated with serum cortisol concentrations (Bozovic, Racic, & Ivkovic, 2013). Salivary cortisol levels increase 5 minutes after an increase in plasma levels and are strongly correlated with plasma levels (Lucassen & Cizza, 2012). Expressive writing has been found to be related to long-term improvements in health (Pennebaker, 1997) and lowered stress levels (Smyth et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Reduction of Cortisol Levels and Participants' Responses Following Art Making

Kaimal¹,

Ray²,

Muñiz³

2016

Art Therapy

190

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This quasi-experimental study investigated the impact of visual art making on the cortisol levels of 39 healthy adults. Participants provided saliva samples to assess cortisol levels before and after 45 minutes of art making. Participants also provided written responses about the experience at the end of the session. Results indicate that art making resulted in statistically significant lowering of cortisol levels. Participants' written responses indicated that they found the art-making session to be relaxing, enjoyable, helpful for learning about new aspects of self, freeing from constraints, an evolving process of initial struggle to later resolution, and about flow/losing themselves in the work. They also reflected that the session evoked a desire to make art in the future. There were weak associations between changes in cortisol level and age, time of day, and participant responses related to learning about one's self and references to an evolving process in art making. There were no significant differences in outcomes based on prior experiences with art making, media choice, or gender.

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Section: Introductionmentioning

confidence: 99%

Reduction of Cortisol Levels and Participants' Responses Following Art Making

Kaimal¹,

Ray²,

Muñiz³

2016

Art Therapy

190

View full text Add to dashboard Cite

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“…Cortisol levels are another indicator of stress [22], and decreases in serum cortisol are believed to be produced by at least some adaptogens [23]. For example, the adaptogen ashwagandha (Withania) significantly reduced stress in adults and significantly decreased serum cortisol levels after 60 days of treatment [24].…”

Section: Discussionmentioning

confidence: 99%

Effects of an Adaptogen-Based Supplement on Stress Parameters in Healthy Volunteers

Shara¹,

Kakish²,

Stohs³

2017

IJCAM

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The effects of an adaptogen-based dietary supplement on stress indicators and stress perception were evaluated in health volunteers using a double-bind, placebo-controlled protocol. Seventy-seven healthy 24-60 year old male and female participants were enrolled, with 74 completing the study. Participants were given a 28-day supply of the supplement or the corresponding placebo and instructed to take 1 oz each morning 30 min. before breakfast. The supplement was a proprietary blend of 10 adaptogens including Eleurtherococcus, Schizandra and Rhodiola extracts, plus B vitamins. On the morning of enrollment, the participants completed a stress perception survey, had blood samples drawn for a highly sensitive C-reactive protein (HS-CRP), cortisol and homocysteine, and returned to the clinic after 28 days to repeat the stress perception survey and blood tests. A 40% reduction (p <0.05) in the number of participants with abnormally elevated HS-CRP in the supplement group compared to the placebo group was observed. Furthermore, there was a 30% reduction in levels of HS-CRP in the supplemented group relative to the placebo group. Only one of the 5 subjects (20%) with abnormal (elevated) serum homocysteine levels remained elevated after 4 weeks of supplementation. In contrast, 4 of the 6 (66%) subjects in the control group remained elevated after 4 weeks. Five stress perception parameters were significantly reduced (10-20%) in the supplemented group compared to two parameters in the placebo group. The results of this study indicate that the adaptogen/vitamin blend is effective at reducing subjective (perception survey) and objective (HS-CRP) stress measures compared to the placebo.

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“…Results of the present study have shown that exposure to high ambient temperature increased the level of CRH in plasma. When the secretion of CRH increases, CRH stimulates the cells of the anterior pituitary to synthesize and release the ACTH, which in turn stimulates the cells of the adrenal cortex to synthesize and release Cor (31,32). A previous human study has shown that Cor is the end result of the HPA-axis activation (33).…”

Section: Discussionmentioning

confidence: 99%

Effects of lycium barbarum polysaccharides on neuropeptide Y and heat-shock protein 70 expression in rats exposed to heat

et al. 2014

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Abstract. The purpose of the present study was to investigate the effects of high ambient temperature on the neuropeptide Y (NPY) mRNA level in the hypothalamus, the plasma concentration of corticotropin-releasing hormone (CRH), cortisol (Cor), heat-shock protein 70 (HSP70) and epinephrine (EPI), and the intervention of lycium barbarum polysaccharides (LBPs) in rats. Compared to the control (CN) group, the plasma levels of CRH, Cor, HSP70 and EPI were markedly increased, and the level of NPY mRNA was downregulated in the high ambient temperature (HT) group. By contrast, rats in the HT + LBP (HTL) group had: i) a significantly enhanced expression of HSP70 compared to the HT and CN groups; ii) clearly increased plasma levels of CRH, Cor and EPI compared to the CN group; and iii) a markedly upregulated expression of NPY mRNA compared to the HT group. Thus, the results showed that high-temperature environments may damage the body, and LBPs have a potentially protective function by increasing the expression of HSP70 and NPY.

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The Hypothalamic-Pituitary-Adrenal Axis, Obesity, and Chronic Stress Exposure: Sleep and the HPA Axis in Obesity

Cited by 74 publications

References 49 publications

Reduction of Cortisol Levels and Participants' Responses Following Art Making

Reduction of Cortisol Levels and Participants' Responses Following Art Making

Effects of an Adaptogen-Based Supplement on Stress Parameters in Healthy Volunteers

Effects of lycium barbarum polysaccharides on neuropeptide Y and heat-shock protein 70 expression in rats exposed to heat

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