The hypothetical role of FoxO1 in acne is interesting, but more study is needed before any conclusions can be drawn

Leyden, James J.; Gollnick, Harald; Thiboutot, Diane; Dréno, Brigitte; Bettoli, Vincenzo; Kang, Seung-Hwa; Shalita, Alan R.; Torres, Vanessa

doi:10.1111/j.1365-2133.2010.10032.x

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…There is increasing interest in the role of FoxO1 and FoxO3 in cutaneous homeostasis and skin diseases . In 2010, inactivation of nuclear FoxO1, a key downstream regulator of the insulin‐like growth factor‐1 (IGF‐1)/AKT pathway, has been deduced to play a key role in the pathogenesis of acne vulgaris, which has been disputed and finally confirmed in immortalized SZ95 sebocytes, sebaceous gland‐rich skin biopsies of acne patients and insulin‐ and IGF‐1 stimulated T cells . Central to FoxO1 and FoxO3 regulation is a shuttling system, which confines FoxOs to either the nucleus or the cytoplasm .…”

Section: Introductionmentioning

confidence: 99%

Effect of oral isotretinoin on the nucleo‐cytoplasmic distribution of FoxO1 and FoxO3 proteins in sebaceous glands of patients with acne vulgaris

Agamia

Roshdy

Abdelmaksoud

et al. 2018

Experimental Dermatology

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Oral isotretinoin is the most effective anti‐acne drug with the strongest sebum‐suppressive effect caused by sebocyte apoptosis. It has been hypothesized that upregulation of nuclear FoxO transcription factors and p53 mediate isotretinoin‐induced sebocyte apoptosis in vivo. It is the aim of our study to analyse the distribution of the pro‐apoptotic transcription factors FoxO1 and FoxO3 in the nuclear and cytoplasmic compartments of human sebocytes in vivo before and during isotretinoin treatment of acne patients. Immunohistochemical analysis of skin biopsies with antibodies distinguishing phosphorylated and non‐phosphorylated human FoxO1 and FoxO3 proteins was performed before isotretinoin treatment, six weeks after initiation of isotretinoin therapy, and in acne‐free control patients not treated with isotretinoin. Our in vivo study demonstrates a significant increase in the nucleo‐cytoplasmic ratio of non‐phosphorylated FoxO1 and FoxO3 during isotretinoin treatment of acne patients. Translational and presented experimental evidence indicates that upregulation of nuclear FoxO1 and FoxO3 proteins is involved in isotretinoin‐induced pro‐apoptotic signalling in sebocytes confirming the scientific hypothesis of isotretinoin‐mediated upregulation of FoxO expression.

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Section: Introductionmentioning

confidence: 99%

Effect of oral isotretinoin on the nucleo‐cytoplasmic distribution of FoxO1 and FoxO3 proteins in sebaceous glands of patients with acne vulgaris

Agamia

Roshdy

Abdelmaksoud

et al. 2018

Experimental Dermatology

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“…There have been 18, and likely will be more, conservative voices who insist on proof beyond doubt. Theirs will be a long wait.…”

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confidence: 99%

“…No doubt we have still more to learn, but this is a giant step forward. There have been , and likely will be more, conservative voices who insist on proof beyond doubt. Theirs will be a long wait.…”

mentioning

confidence: 99%

Turning acne on/off via mTORC1

Danby

2013

Experimental Dermatology

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Over the past 10 years, the increase in comprehension of the mechanisms behind acne has been truly exponential. Starting with the ethnological work of Cordain, accelerated by the epidemiological work of Adebamowo, supported by the clinical trials of Smith and Mann, Kwon, DiLandro and others, the interface of diet and acne is coming into focus. Melnik now presents an exceptional pair of papers that illustrate for dermatologists what translational research is all about. The Western diet, the role of dairy, FoxO1 and mTORC1, the interplay of agonists and antagonists, therapeutics present and future – the jigsaw puzzle is coming together.

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Mechanistic target of rapamycin (mTOR) expression is increased in acne patients' skin

Monfrecola

Lembo

Caiazzo

et al. 2015

Experimental Dermatology

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The hypothetical role of FoxO1 in acne is interesting, but more study is needed before any conclusions can be drawn

Cited by 4 publications

References 7 publications

Effect of oral isotretinoin on the nucleo‐cytoplasmic distribution of FoxO1 and FoxO3 proteins in sebaceous glands of patients with acne vulgaris

Effect of oral isotretinoin on the nucleo‐cytoplasmic distribution of FoxO1 and FoxO3 proteins in sebaceous glands of patients with acne vulgaris

Turning acne on/off via mTORC1

Mechanistic target of rapamycin (mTOR) expression is increased in acne patients' skin

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