The
 in Vitro
 and
 in Vivo
 Activity of Streptomycin Against
 Hemophilus pertussis

Hegarty, Chris; Thiele, Elizabeth H.; Verwey, W. F.

doi:10.1128/jb.50.6.651-654.1945

Cited by 21 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is an incremental quantitative transition from sublethal to lethal dosing. With intracerebral inoculation, there is a dose-dependency for time to death and animal mortality rate (Hegarty et al 1945 ; Andersen and Bentzon 1958a ). For intranasal or aerosol exposure, there is a dose-related increase in the infection rate, and infection can vary depending on the volume of inoculum (Halperin et al 1988 ).…”

Section: Non-primate Animal Models Of Pertussismentioning

confidence: 99%

“…Viable counts of bacteria in the animal lung are also higher in a dose-dependent fashion (Proom 1947 ; Fisher 1958 ; Sato and Sato 1988 ). The death rate among mice increases, and the time to death decreases also proportionate to the increasing inoculum (Hegarty et al 1945 ; Proom 1947 ; Bradford and Day 1949 ; Standfast 1951 , 1958 ; Fisher 1958 ; Gastal 1958 ). Furthermore, there is an age-dependent response (Burnet and Timmins 1937 ; Culotta et al 1938a ; Standfast 1951 ; Pittman et al 1980 ; Sato et al 1980 ; Standfast 1951 ).…”

Section: Non-primate Animal Models Of Pertussismentioning

confidence: 99%

“…The protective effects of passive immunity were assessed in this model (Holt 1972 ). It had also been used briefly and successfully to assess antimicrobial therapy for pertussis (Hegarty et al 1945 ; Brownlee and Bushby 1948 ; Bell et al 1949 ).…”

Section: Non-primate Animal Models Of Pertussismentioning

confidence: 99%

See 2 more Smart Citations

Non-primate animal models for pertussis: back to the drawing board?

Cimolai

2022

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

Despite considerable progress in the understanding of clinical pertussis, the contemporary emergence of antimicrobial resistance for Bordetella pertussis and an evolution of concerns with acellular component vaccination have both sparked a renewed interest. Although simian models of infection best correlate with the observed attributes of human infection, several animal models have been used for decades and have positively contributed in many ways to the related science. Nevertheless, there is yet the lack of a reliable small animal model system that mimics the combination of infection genesis, variable upper and lower respiratory infection, systemic effects, infection resolution, and vaccine responses. This narrative review examines the history and attributes of non-primate animal models for pertussis and places context with the current use and needs. Emerging from the latter is the necessity for further such study to better create the optimal model of infection and vaccination with use of current molecular tools and a broader range of animal systems. Key points • Currently used and past non-primate animal models of B. pertussis infection often have unique and focused applications. • A non-primate animal model that consistently mimics human pertussis for the majority of key infection characteristics is lacking. • There remains ample opportunity for an improved non-primate animal model of pertussis with the use of current molecular biology tools and with further exploration of species not previously considered. Graphical abstract

show abstract

Section: Non-primate Animal Models Of Pertussismentioning

confidence: 99%