The Immunologic Profile of Vitamin D and Its Role in Different Immune-Mediated Diseases: An Expert Opinion

Giannini, Sandro; Giusti, Andrea; Minisola, Salvatore; Napoli, Nicola; Passeri, Giovanni; Rossini, Maurizio; Sinigaglia, Luigi

doi:10.3390/nu14030473

Cited by 30 publications

(12 citation statements)

References 176 publications

(240 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vitamin D has known effects on innate and adaptive immunity. Multiple pleiotropic effects have been demonstrated on the actions of vitamin D at the anti-inflammatory and immunomodulatory levels [ 32 , 33 ]. Vitamin D affects the maturation of T cells with a decrease in the inflammatory Th17 phenotype and an increase in T regulatory cells.…”

Section: Discussionmentioning

confidence: 99%

Association between Vitamin D Serum Levels and Immune Response to the BNT162b2 Vaccine for SARS-CoV-2

et al. 2022

View full text Add to dashboard Cite

The use of micronutrients such as vitamin D could improve the response to viral vaccines, particularly in immunosuppressed and immunosenescent subjects. Here, we analysed the association between serum 25-hydroxyvitamin D (25OHD) levels and the immune response elicited by the BNT162b2 vaccine in a cohort of 101 healthcare workers naïve for SARS-CoV-2 infection. We observed no significant differences in anti-spike (S) IgG and T-cell responses according to the 25OHD status at baseline. However, significant correlations between the 25OHD concentration at baseline and (i) the anti-S response (p < 0.020) and (ii) the neutralizing antibody (NT) titre (p = 0.040) at six months after the second dose were detected. We concluded that adequate levels of vitamin D may improve the immune response to mRNA vaccines such as BNT162b2, and that further larger studies are warranted in order to confirm these preliminary observations.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between Vitamin D Serum Levels and Immune Response to the BNT162b2 Vaccine for SARS-CoV-2

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Vitamin D supplementation was associated with improved blood vessel function in children with diabetes [ 70 , 71 ]. Whether vitamin D supplementation can be preventive in the general population or those likely to develop CVD is still open to debate [ 72 , 73 ].…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Selected Inflammation and Oxidative Stress Biomarkers and Carotid Intima-Media Thickness (IMT) Value in Youth with Type 1 Diabetes Co-Existing with Early Microvascular Complications

Peczyńska

Klonowska

Żelazowska-Rutkowska

et al. 2022

JCM

View full text Add to dashboard Cite

Recent years have confirmed the importance of oxidative stress and biomarkers of inflammation in estimating the risk of cardiovascular disease (CVD) and explaining not fully understood pathogenesis of diabetic macroangiopathy. We aimed to analyze the relation between the intima-media thickness (IMT) of common carotid arteries and the occurrence of classical cardiovascular risk factors, together with the newly proposed biomarkers of CVD risk (high-sensitivity C-reactive protein (hsCRP), myeloperoxidase (MPO), adiponectin, N-terminal-pro B-type natriuretic peptide (NT-proBNP) and vitamin D) in youth with type 1 diabetes (T1D) recognized in screening tests to present early stages of microvascular complications (VC). The study group consisted of 50 adolescents and young adults with T1D, mean age 17.1 years (10–26 age range), including 20 patients with VC (+) and 30 VC (−). The control group (Control) consisted of 22 healthy volunteers, mean age 16.5 years (11–26 age range). In the VC (+) patients, we found a significantly higher concentration of HbA1c, lipid levels, hsCRP and NT-proBNP. BMI and blood pressure values were highest in the VC (+) group. Higher levels of MPO and lower levels of vitamin D were found in both diabetic groups vs. Control. IMT in VC (+) patients was significantly higher and correlated positively with HbA1c, hsCRP, NT-pro-BNP and negatively with vitamin D levels. In conclusion, youth with T1D and VC (+) present many abnormalities in the classical and new CVD biomarkers. hsCRP and MPO seem to be the most important markers for estimating the risk of macroangiopathy. NT-proBNP may present a possible marker of early myocardial injury in this population.

show abstract

“…Vitamin D plays a vital role in immunological effects 44 as well as prevention and cure of Mtb. At present, TB has become a severe problem especially due to a large increase in MDR-TB and XDR-TB cases.…”

Section: Discussionmentioning

confidence: 99%

“…But, no mRNA up-regulation was observed for other VDR downstream target genes like CAMP, DEFB4, [1,25(OH) 2 D 3 ] regulated VDR-specific Cyp24 hydroxylase gene. 17 proteins, DEFB4 and CAMP 44 . Intriguingly, although both CAMP and DEFB4 genes display proximal promoter direct-repeat 3 (DR3), consensus VDREs and CAMP can only be induced transcriptionally via [1,25(OH) 2 D 3 ] in monocytes 24 .…”

Section: Molecular Mechanism Of Vitamin D's Role In Immunitymentioning

confidence: 99%

Molecular Interplay between Vitamin D and Immunity can Aid Antitubercular Treatment Vitamin D in Immunomodulation of TB

Das¹,

Banerjee

Karak³

2022

Def. Life. Sc. Jl.

View full text Add to dashboard Cite

Tuberculosis (TB) causes maximum mortality and morbidity worldwide. 25 per cent of the global population harbour Mycobacterium tuberculosis (Mtb) and therefore are at risk of developing active disease. Of late, the disseminated diseases of TB are on the increase. Nearly one-third of all TB infections can be classified as extrapulmonary-TB (EPTB). TB can spread to the bone, brain, intestine, peritoneum, genitourinary system, and female genital sites leading to problems of conception. Therefore undoubtedly, TB has turned out to be a tremendous public health problem globally. The emergence of drug-resistant bacteria calls for new anti-tuberculous drugs to enhance response to antimicrobial therapy for active TB. However, discoveries of very effective anti-TB new medicines have not materialised yet. Thus, nutritional anti-TB intervention is highly important. In the pre-antibiotic era, Vitamin D was used for the treatment of TB. Its active component 1,25-dihydroxy-vitamin D3 was shown to display anti-TB activity in vitro. Vitamin D deficient humans display greater susceptibility to TB. Vitamin D deficiency induces worse disease progression in TB cases as observed in many clinical trials. The efficacy of the addition of vitamin D supplements in TB treatment has also been estimated. Thus, by now, the role of vitamin D in TB prevention and treatment is well established. Knowledge of the molecular mechanism of vitamin D is crucially vital for new anti-TB drug design. This review article discusses the recent advancement regarding the molecular mechanism of vitamin D-related anti-TB action. Further elucidation of this area may help novel anti-TB drug development.

show abstract

The Immunologic Profile of Vitamin D and Its Role in Different Immune-Mediated Diseases: An Expert Opinion

Cited by 30 publications

References 176 publications

Association between Vitamin D Serum Levels and Immune Response to the BNT162b2 Vaccine for SARS-CoV-2

Association between Vitamin D Serum Levels and Immune Response to the BNT162b2 Vaccine for SARS-CoV-2

The Relationship between Selected Inflammation and Oxidative Stress Biomarkers and Carotid Intima-Media Thickness (IMT) Value in Youth with Type 1 Diabetes Co-Existing with Early Microvascular Complications

Molecular Interplay between Vitamin D and Immunity can Aid Antitubercular Treatment Vitamin D in Immunomodulation of TB

Contact Info

Product

Resources

About