The immunological aspects of keloid tumor formation

Kazeem, A A

doi:10.1002/jso.2930380106

Cited by 53 publications

(29 citation statements)

References 5 publications

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“…Immunological alterations were documented by various research groups. In comparison to healthy skin, patients who develop keloids have a high incidence of allergic diathesis and elevated levels of serum concentrations for the immunoglobulins IgG, IgA and IgM (8,47,(62)(63)(64)(65). Multiple studies found trends in the patterns of serum complement and immunoglobulin G and immunoglobulin M levels in keloid-forming patients (62)(63)(64).…”

Section: Genetics and Immunologymentioning

confidence: 99%

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Keloids: Current concepts of pathogenesis (Review)

Bran¹

2009

Int J Mol Med

193

214

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Abstract. Excess scar formation occurs after dermal injury as a result of abnormal wound healing. Hypertrophic scars and keloids both represent fibrotic skin conditions which can be very difficult, even frustrating, to treat. Identification of differences between hypertrophic scars, keloids and normal scars are a prerequisite for finding the correct therapeutical concept. Despite the relatively high prevalence of keloids in the general population, the mechanisms underlying keloid formation are only partially understood. This fact is reflected in the multiple treatment modalities, of which no single treatment has proven to be widely effective. Advances in our understanding of the wound healing process reveal new pathophysiological concepts for keloid formation. Our article presents an overview on physiological wound healing and the pathogenesis of scar formation, differentiates keloids from hypertrophic scars and reviews current hypotheses for keloid formation. This information might assist in deciphering the complexity of keloid pathogenesis and help in the development of an efficacious therapeutical strategy.

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Section: Genetics and Immunologymentioning

confidence: 99%

“…In line with the immune-response hypothesis, Appleton and coworkers noted numerous apoptotic cells at the interface between dermis and keloids, a feature characteristic of cellmediated immune attack (57). The resulting considerations vary from a local immune reaction to an autoimmune connective tissue disease (64,66).…”

Section: Genetics and Immunologymentioning

confidence: 99%

Keloids: Current concepts of pathogenesis (Review)

Bran¹

2009

Int J Mol Med

193

214

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“…Hypertrophic scars typically occur in wounds where healing was delayed, perhaps where complications such as infection or dehiscence occurred. They tend to be commoner in children [13] perhaps because of the evolving immune system at this stage of life. They also occur where skin tension is high such as the tip of the shoulder or any scar that runs across relaxed skin tension lines [14].…”

Section: Discussionmentioning

confidence: 99%

Unusually Located Keloids - The Role of Cultural Practices in its Etiology

Tat¹,

Irekpita²

2011

J Clin Exp Dermatol

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Keloids are an exuberant growth of scar tissue extending beyond the boundaries of the original wound causing it and are mainly due to excessive collagen tissue synthesis. They have predilection for certain sites in the human body.There is an increasing trend for the location of such keloidal scars in parts of the body where they are not supposed to be.Certain cultural practices are responsible for this situation particularly in the African context. One of such practice that leads to this type of unusual complication is presented below and the pathogenesis as well as other aspects of keloidal growth are reviewed in general. Figure 1: Below is also another perfectly healed scar done while the patient was young. Healing here is similar to the figure above. However, note the discolouration (? bluish hue) of the scars with its cosmetic effect! In some tribes, this is the reason for this practice. Unusually Located Keloids-The Role of Cultural Practices in its Etiology Journal of Clinical & Experimental Dermatology Research

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“…Rossi et al [15] haben beschrieben, dass zwar die IgG-und IgM-Serumspiegel sowie die Komplementfaktoren C3 und C4 im Serum von Patienten mit Keloiden normal sind, dass aber das läsionäre IgG in Keloiden signifikant erhöht ist. Für IgA und IgM sind ebenfalls erhöhte intralä-sionale Konzentrationen im Vergleich zu gesunder Haut beschrieben [19,20,21].…”

Section: Genetik Und Immunologieunclassified

Keloide Eine dermale fibroproliferative Erkrankung unbekannter Ursache

Böck¹,

Mrowietz²

2002

Hautarzt

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We review recent advances in keloid research and treatment. Keloids are benign tumours of the skin. They tend to occur in younger patients after different kinds of injuries, infections or they may develop spontaneously. In contrast to hypertrophic scars, keloids are not confined to the original wound, but grow into the corresponding healthy skin. They rarely recede within time. Most patients complain of itching and suffer from impairment of their quality of life. Only little is known about the pathogenesis of keloids, although they have been clinically well characterized for a long time. New results point towards a disruption in the signaling pathway of TGFbeta. In addition there seems to be evidence of an increased familiar incidence and therefore the genetic background should be screened. Successful treatment of keloids is difficult. As contact cryotherapy and intralesional corticosteroid injections are in most cases not successful, the pulsed dye-laser seems to be a promising alternative. In addition topical treatment with extracts of onions, occlusive silicone sheets and pressure improves the clinical appearance of keloids.

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The immunological aspects of keloid tumor formation

Cited by 53 publications

References 5 publications

Keloids: Current concepts of pathogenesis (Review)

Keloids: Current concepts of pathogenesis (Review)

Unusually Located Keloids - The Role of Cultural Practices in its Etiology

Keloide Eine dermale fibroproliferative Erkrankung unbekannter Ursache

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