The immunopathogenesis of oral lichen planus—Is there a role for mucosal associated invariant T cells?

DeAngelis, Lara Marie; Cirillo, Nicola; McCullough, Michael

doi:10.1111/jop.12898

Cited by 49 publications

(44 citation statements)

References 53 publications

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“…OLP is a relatively common inflammatory disease that typically affects middle‐aged adults, with a female predilection 10 . Interestingly, despite the voluminous research on the topic, the exact etiopathogenesis of OLP is still unclear 9,10 . However, current evidence suggests that OLP is a T cell–mediated autoimmune disease 10 .…”

Section: Discussionmentioning

confidence: 99%

“…The exact etiopathogenesis of OLP remains poorly understood 9,10 . However, current evidence suggests an autoimmune response to an unknown trigger 9 .…”

Section: Introductionmentioning

confidence: 99%

“…The exact etiopathogenesis of OLP remains poorly understood 9,10 . However, current evidence suggests an autoimmune response to an unknown trigger 9 . Psychogenic factors, genetic predisposition, allergy to dental materials and drugs, systemic diseases such as diabetes mellitus and thyroid disorders, and viral infections such as hepatitis C virus (HCV), human papilloma viruses (HPV), and Epstein‐Barr virus (EBV) have been proposed as predisposing factors 10‐14 …”

Section: Introductionmentioning

confidence: 99%

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The association between Epstein‐Barr virus and oral lichen planus: A systematic review and meta‐analysis

Ashraf

Al‐Maweri

Alaizari

et al. 2020

J Oral Pathology Medicine

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Background Oral lichen planus (OLP) is a relatively common inflammatory disease, with unclear etiology. A number of studies have linked Epstein‐Barr virus (EBV) with OLP. The present systematic review and meta‐analysis aimed to evaluate the available evidence regarding the potential association between EBV and OLP. Methods Online databases (PubMed, Scopus, Web of Science, ProQuest, and Google Scholar) were searched from date of inception till May 2020. Studies were included if they met the following criteria: 1) observational studies that assessed the relationship between EBV and OLP, 2) the study comprised OLP patients and control subjects, 3) diagnosis of OLP was confirmed histopathologically, and 4) articles were in English. Studies without control groups, experimental studies, case reports, and reviews were excluded. The fixed‐effects model was performed for meta‐analyses using RevMan 5.3 software. Results A total of 10 studies comprising 386 OLP cases and 304 controls were included. Of these, only 8 studies were eligible for the meta‐analysis. The results of the quality assessment showed that only 2 studies were of high quality, while the remaining studies were of moderate quality. The results of the pooled eight studies revealed a significant positive association between EBV and OLP (OR = 4.41, 95% CI: [2.74, 7.11], P < .0001). Conclusion The results of the present systematic review suggest that EBV infection is statistically associated with increased risk of OLP. However, these results are preliminary, and high‐quality, large‐scale studies are warranted to further explore the potential role of EBV in the pathogenesis of OLP.

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Section: Discussionmentioning

confidence: 99%

“…The exact etiopathogenesis of OLP remains poorly understood 9,10 . However, current evidence suggests an autoimmune response to an unknown trigger 9 .…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The association between Epstein‐Barr virus and oral lichen planus: A systematic review and meta‐analysis

Ashraf

Al‐Maweri

Alaizari

et al. 2020

J Oral Pathology Medicine

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“…Immune Factors. The histopathological features of OLP and HT indicate that the cell-mediated immune response plays an important role in their pathogenesis [13,14]. The typical histological features of OLP include subepithelial band-like infiltration of lymphocytes (mostly T lymphocytes), liquefaction degeneration of basal epithelial cells, and hyperparakeratosis.…”

Section: Potential Mechanisms Underlying Thementioning

confidence: 99%

Possible Mechanisms Involved in the Cooccurrence of Oral Lichen Planus and Hashimoto’s Thyroiditis

Luo

Zhou

et al. 2020

Mediators of Inflammation

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Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disorder mediated by T cells, with a multifactorial etiology. Hashimoto’s thyroiditis (HT) is a common autoimmune disease characterized by hypothyroidism. Although many clinical studies conducted over the past several decades have reported the cooccurrence of OLP and HT, the underlying mechanism remains unclear. This review summarizes potential mechanisms that might be involved in the cooccurrence of OLP and HT. We find that OLP and HT share a common or overlapping pathogenesis in terms of immune, heredity, environmental, and hormonal factors, which might cause cooccurrence. Furthermore, considering the latency of HT, a routine screen for thyroid diseases, particularly HT, is suggested for confirmed OLP patients.

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“…Oral lichen planus (OLP) is a common chronic inflammatory disease involving oral mucosa of probable immune-based etiology, 1 characterized by subepithelial bandlike infiltration of lymphocytes and liquefactive degeneration of the basal keratinocytes. 1 OLP often severely affects the patients' quality of life due to a protracted clinical course despite various available treatments [2][3][4] and, in particular, the potential for malignant transformation, 5,6 Currently, inflammation-related cytokines have been reported to be involved in the pathogenesis of OLP. 7 Thus, the research on the effects of the cytokines involved in the immunopathogenesis of OLP is important to explore novel therapeutic approaches of OLP compared to steroid treatment.…”

Section: Introductionmentioning

confidence: 99%

Altered expression of CCN1 in oral lichen planus associated with keratinocyte activation and IL‐1β, ICAM1, and CCL5 up‐regulation

Wang

Shi

et al. 2020

J Oral Pathology Medicine

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Background: Emerging evidence indicates that CCN1 is a novel inflammation-regulated mediator involved in the pathogenesis of some immune-mediated inflammatory diseases. The objective of this study was to investigate the preliminary roles of CCN1 and its related cytokines IL-1β, CCL5, and ICAM1 in oral lichen planus (OLP). Methods: CCN1 expression levels in biopsies from OLP patients against normal oral mucosa (NOM) using immunohistochemistry (42 OLP vs 9 NOM) and RT-qPCR (20 OLP vs 20 NOM) were compared, respectively. The correlation of CCN1 and IL-1β, CCL5, and ICAM1 expression was examined by RT-qPCR in tissue samples and an in vitro cell culture system using keratinocyte HaCaT cells incubated with lipopolysaccharides. Results: Immunohistochemistry showed that CCN1 protein mainly expressed in the cytoplasm of epithelial keratinocytes of OLP. Consistently, RT-qPCR revealed that mRNA expression of CCN1 was increased in OLP compared with NOM (P < .05) and positively correlated with the high expression of IL-1β, ICAM1, and CCL5 (P < .001), respectively. Importantly, an in vitro study showed that keratinocyte proliferation significantly (P < .05) increased by CCN1 stimulation. Moreover, IL-1β, ICAM1, and CCL5 expression in keratinocytes stimulated by CCN1 was increased (P < .05), respectively. Conclusions: This preliminary study for the first time reported that altered expression of CCN1 was associated with high expression of IL-1β, ICAM1, and CCL5 in OLP. And we demonstrated CCN1 promoted keratinocyte activation, as well as IL-1β, ICAM1, and CCL5 production in keratinocytes. Our data indicated that the potential role of CCN1 and its related cytokines was involved in the pathogenesis of OLP.

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The immunopathogenesis of oral lichen planus—Is there a role for mucosal associated invariant T cells?

Cited by 49 publications

References 53 publications

The association between Epstein‐Barr virus and oral lichen planus: A systematic review and meta‐analysis

The association between Epstein‐Barr virus and oral lichen planus: A systematic review and meta‐analysis

Possible Mechanisms Involved in the Cooccurrence of Oral Lichen Planus and Hashimoto’s Thyroiditis

Altered expression of CCN1 in oral lichen planus associated with keratinocyte activation and IL‐1β, ICAM1, and CCL5 up‐regulation

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