The impact of cigarette/e‐cigarette vapour on simulated pulmonary surfactant monolayers under physiologically relevant conditions

Abstract

The impact of cigarette/e-cigarette vapour on simulated pulmonary surfactant monolayers under physiologically relevant conditions http://researchonline.ljmu.ac.uk/5333/ Article LJMU has developed LJMU Research Online for users to access the research output of the University more effectively. Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Users may download and/or print one copy of any article(s) in LJMU Research Online to facilitate their private study or for non-commercial research. You may not engage in further distribution of the material or use it for any profit-making activities or any commercial gain. LJMU Research OnlineThe version presented here may differ from the published version or from the version of the record. Please see the repository URL above for details on accessing the published version and note that access may require a subscription. Deviation in pulmonary surfactant structure-function activity can impair airway patency and lead to respiratory 8 disorders. This novel study aims to evaluate the influence cigarette / e-cigarette vapour has on model 9 surfactant films located within a simulated pulmonary environment using a lung biosimulator. 10Chromatographic analysis confirmed that nicotine levels were consistent with the sampling regimen

Physicochemical studies of direct interactions between lung surfactant and components of electronic cigarettes liquid mixtures

“…Also in this case, it was impossible to estimate the real concentration of deposited vapor in the studied gas-liquid system. Contrary to the results of Przybyla et al (2017), Davies et al (2017) found a deflection and a shift of compression isotherm which suggested a direct interactions of EC-vapor components with the interfacial film of model LS. As a result, the surface tension could not be reduced to the same degree as if the EC-vapor components were absent.…”

“…On the other hand, atomic force microscopy studies of the surfactant layer transferred to solid support revealed some alterations in lateral arrangement of surfactant components at the interface even at these low concentrations of EC-vapor components. Studies with the Langmuir trough were also published by Davies et al (2017) who used main LS lipids instead of animal-based surfactant. Lipid monolayer was directly exposed to vapor (aerosol), which was drawn into the experimental chamber.…”

The influence of cannabis smoke and cannabis vapour on simulated lung surfactant function under physiologically relevant conditions

“…Cannabis vapour and smoke contain the lipophilic Δ9‐THC molecule that is capable of disrupting a surfactant monolayer. This is so as these molecules can insert themselves directly into the monolayer, between surfactant molecules, and interrupt monolayer function, particularly in the solid phase during compression . This would result in a less rigid surface film with increased elasticity, which was noted herein.…”

An investigation into drug partitioning behaviour in simulated pulmonary surfactant monolayers with associated molecular modelling

“…Variation in the monomolecular structure results further to drug partitioning with either the drug causing expanded regions to become more condensed in nature via insertion within accessible areas or direct interaction between drug molecule and surfactant components, as modelled herein. Such modification to the surfactant film in the (deep) lung can influence structure‐function activity; however, in general terms, the surfactant film appears robust and resilient to external stressors (ie, drug substances and environmental toxins), and this allows it to fulfil its crucial biological function.…”