The Impact of Diet on Microbiota Evolution and Human Health. Is Diet an Adequate Tool for Microbiota Modulation?

Moles, Laura; Otaegui, David

doi:10.3390/nu12061654

Cited by 54 publications

(43 citation statements)

References 121 publications

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“…Modern life is intimately linked to changes in eating habits, which in turn impact the composition of the intestinal microbiota. Indeed, human evolution has been accompanied by incessant changes in lifestyle (including diet) [136][137][138]. Thus, humans evolved from being nomadic hunter-gatherers to a sedentary civilization practicing a new lifestyle based on agriculture and animal husbandry.…”

Section: Discussionmentioning

confidence: 99%

Bioactive Compounds in Food as a Current Therapeutic Approach to Maintain a Healthy Intestinal Epithelium

et al. 2021

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The intestinal epithelium serves as an effective barrier against the external environment, hampering the passage of potentially harmful substances (such as pathogenic microbes) that could trigger an exacerbated host immune response. The integrity of this barrier is thus essential for the maintenance of proper intestinal homeostasis and efficient protective reactions against chemical and microbial challenges. The principal consequence of intestinal barrier defects is an increase in intestinal permeability, which leads to an increased influx of luminal stressors, such as pathogens, toxins, and allergens, which in turn trigger inflammation and immune response. The fine and fragile balance of intestinal homeostasis can be altered by multiple factors that regulate barrier function, many of which are poorly understood. This review will address the role of gut microbiota as well as food supplements (such as probiotics, prebiotics, and synbiotics) in modulating gut health and regulating intestinal barrier function. In particular, we will focus on three human pathologies: inflammatory bowel disease, irritable bowel syndrome, and food allergy.

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Section: Discussionmentioning

confidence: 99%

Bioactive Compounds in Food as a Current Therapeutic Approach to Maintain a Healthy Intestinal Epithelium

et al. 2021

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“…Fermentation facilitates the liberation and absorption of insoluble bound phenolics involved in colorectal cancer prevention. The degradation of phenolic acids by enteric bacterial or chemical conversions may produce other metabolites, including protocatechuic acid, syringic acid, vanillic acid, phloroglucinol aldehyde, phloroglucinol acid, and gallic acid [3,9,15,20,21,24,30,63,69].…”

Section: Intestinal Absorptionmentioning

confidence: 99%

“…Several studies have shown that the gut has a greater impact than food processing and nutrient absorption. Gut health is a function of the gut barrier and gut microbiota essential elements for better health [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Phenolic Compounds in Legumes: Composition, Processing and Gut Health

Nicolás-García¹,

Jiménez‐Martínez²,

Perucini-Avendaño³

et al. 2022

Legumes Research - Volume 2

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Gut health is fundamental for human well-being and prevents chronic degenerative diseases and is influenced by the interaction between gut microbiota and food components. In recent years, interest in phenolic compounds has increased due to their health benefits such as antioxidant, antidiabetic, antimicrobial, anti-atherosclerotic, anti-inflammatory, anticarcinogenic, cardio- and neuro-protective properties. Legumes are an essential source of phytochemicals, particularly flavonoids and phenolic acids, distributed mainly in the seed coat, and have been reported to exhibit multiple biological effects. Flavonoids present in legumes have been shown to regulate metabolic stability and membrane transport in the intestine, thus improving bioavailability. Seed processing such as cooking allows the release of phenolic compounds, improving polyphenols digestion and absorption at the intestinal level, maintaining their protective capacity in the oxidative process at the cellular level, and modulating the gut microbiota. All these actions improve gut health, avoiding diseases like irritable bowel syndrome, inflammatory bowel disease, obesity, diabetes, colitis, and colorectal cancer. The effect of the consumption of legumes such as chickpea, pea, and bean, as well as the contribution of phenolic compounds to gut health, will be reviewed in this study.

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“…Likewise, the holobiont mind challenges the traditional conception of cognition occurring ontologically only in the brain (Adams & Aizawa, 2001;Rossi et al, 2019). At an evolutionary level, the holobiont concept is highly relevant as it positions evolution not only as the driving force for adaptation but scales up natural selection to multi-level processes (Moeller & Sanders, 2020;Moles & Otaegui, 2020;Theis et al, 2016). Thus, the holobiont concept is indisputably biogenic (Lyon, 2006), as it offers novel principles for biological organization, re-defines the unit of analysis for understanding evolutionary fitness, and naturally offers a framework for comprehending the origin and function of cognition.…”

Section: The Holobiont Mindmentioning

confidence: 99%

The holobiont mind: A bridge between 4E-cognition and the microbiome

Palacios-García¹,

Fj²

2021

Preprint

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All life on earth is intrinsically linked. At the very foundation of everyevolutionary interaction are microorganisms; integral components in thecomposition of both organisms and ecosystems. This perspectivechallenges the traditional conception of monogenetic biologicalindividuals, suggesting living beings are actually composite multi-speciescomplexes; holobionts. In the present article, we introduce the conceptof the holobiont mind; a biogenic conception of cognition. Wefurthermore expand on the idea of the mind as the emerging product ofmulti-genomic morphology of a composite agent, in ever changinginteraction with its ecological niche. We briefly review recent evidence onthe Brain-Gut-Microbiome axis and the Microbiome of the BuiltEnvironment in order to provide a bridge between the Holobiont Mindand the 4E approach to Cognition, two complementary lines of evidencethat have not been linked before, opening novel venues for research withdirect impact on health and disease.

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The Impact of Diet on Microbiota Evolution and Human Health. Is Diet an Adequate Tool for Microbiota Modulation?

Cited by 54 publications

References 121 publications

Bioactive Compounds in Food as a Current Therapeutic Approach to Maintain a Healthy Intestinal Epithelium

Bioactive Compounds in Food as a Current Therapeutic Approach to Maintain a Healthy Intestinal Epithelium

Phenolic Compounds in Legumes: Composition, Processing and Gut Health

The holobiont mind: A bridge between 4E-cognition and the microbiome

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