In order to study the countermeasures of online travel OTA under the epidemic situation, taking Ctrip as the research object, this paper analyzes explicitly its corporate strategy and business strategy and puts forward suggestions and prospects for the future development of Ctrip. The results showed that Ctrip adopted the strategy of tourism marketing hub and the strategy of rural tourism revitalization in the face of the epidemic's impact. Specific performance through live presale, pay attention to the surrounding tour and domestic and foreign development of three aspects. These ways to enable Ctrip to pass the epidemic smoothly