The relevance of the innovative development of regional economies is dictated by both an internal factor (balanced development of territories) and an external factor (the country’s competitiveness in the world market). The authors highlight the threats that may arise in different areas of the region’s economic activity. The rating system for assessing the innovation climate in the region has been substantiated and developed. The methodology of the author’s rating assessment of the innovation climate in the region allows a systematic approach to the qualitative and quantitative characteristics of the state of the innovation climate in the region (good, normal, pre-crisis, crisis). On the basis of the developed assessment system, a multi-paradigm model of the formation of an innovation climate in the region is proposed. The proposed author’s model, which reflects the system of factors of the innovation climate in the region, makes it possible to form ways of forming an innovation climate in the context of the selected areas. It seems that the proposed rating system of assessment and the model interconnected with it have applied significance, an integrated approach will allow assessing the level of the innovation climate in the region, and the proposed model will help to develop effective measures to form an innovative climate. The results of the work are the proposed rating system of assessment and a multi-paradigm model interconnected with it. In conclusion, the authors made a number of proposals for the formation of an innovative climate in the region.