The impact of manure and soil texture on antimicrobial resistance gene levels in farmlands and adjacent ditches

Macedo, G.; Hernández-Leal, Lucia; Maas, Peter van der; Heederik, Dick; Mevius, Dik; Schmitt, Heike

doi:10.1016/j.scitotenv.2020.139563

Cited by 40 publications

(23 citation statements)

References 62 publications

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“…macrolide resistance [86]. Several studies report erm genes in manured soil [82,[87][88][89][90]. Swine manure seems to have a higher content of erm genes than bovine manure samples [85], and a high diversity.…”

Section: Antibiotics and Antimicrobial Resistance Genes In Manurementioning

confidence: 99%

“…Various erm genes have been found in swine waste lagoons: ermA , ermB , ermC , ermF , ermG , ermT , ermQ and ermX, with ermB and ermF being the most prevalent. Remarkably, the ermB gene was never detected in non-manured soils or before the first spring manure amendment, which is strongly suggestive of the introduction of this gene into soil via manure application [ 89 ]. The erm(B) gene has often been found to be associated with the presence of tetM , probably because these genes are frequently integrated together on the Tn 916 -Tn 1545 family of conjugative transposons [ 91 ].…”

Section: Composition Of Manurementioning

confidence: 99%

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Manure as a Potential Hotspot for Antibiotic Resistance Dissemination by Horizontal Gene Transfer Events

Lima

Domingues

Silva

2020

Veterinary Sciences

140

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The increasing demand for animal-derived foods has led to intensive and large-scale livestock production with the consequent formation of large amounts of manure. Livestock manure is widely used in agricultural practices as soil fertilizer worldwide. However, several antibiotic residues, antibiotic resistance genes (ARGs) and antibiotic-resistant bacteria are frequently detected in manure and manure-amended soils. This review explores the role of manure in the persistence and dissemination of ARGs in the environment, analyzes the procedures used to decrease antimicrobial resistance in manure and the potential impact of manure application in public health. We highlight that manure shows unique features as a hotspot for antimicrobial gene dissemination by horizontal transfer events: richness in nutrients, a high abundance and diversity of bacteria populations and antibiotic residues that may exert a selective pressure on bacteria and trigger gene mobilization; reduction methodologies are able to reduce the concentrations of some, but not all, antimicrobials and microorganisms. Conjugation events are often seen in the manure environment, even after composting. Antibiotic resistance is considered a growing threat to human, animal and environmental health. Therefore, it is crucial to reduce the amount of antimicrobials and the load of antimicrobial resistant bacteria that end up in soil.

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Section: Antibiotics and Antimicrobial Resistance Genes In Manurementioning

confidence: 99%

Section: Composition Of Manurementioning

confidence: 99%

Manure as a Potential Hotspot for Antibiotic Resistance Dissemination by Horizontal Gene Transfer Events

Lima

Domingues

Silva

2020

Veterinary Sciences

140

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“…It is of high relevance that there is an extensive bibliography on the increase in genes resistant to both tetracyclines [219][220][221][222][223][224] and sulfonamides [225][226][227][228][229][230][231][232], in bacteria from soils amended with livestock residues, a phenomenon of great concern to public health throughout the world, due to the possible transfer of resistance from microorganisms from the soil to human pathogens [233].…”

Section: Influence On Soil Organismsmentioning

confidence: 99%

Tetracycline and Sulfonamide Antibiotics in Soils: Presence, Fate and Environmental Risks

et al. 2020

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Veterinary antibiotics are widely used worldwide to treat and prevent infectious diseases, as well as (in countries where allowed) to promote growth and improve feeding efficiency of food-producing animals in livestock activities. Among the different antibiotic classes, tetracyclines and sulfonamides are two of the most used for veterinary proposals. Due to the fact that these compounds are poorly absorbed in the gut of animals, a significant proportion (up to ~90%) of them are excreted unchanged, thus reaching the environment mainly through the application of manures and slurries as fertilizers in agricultural fields. Once in the soil, antibiotics are subjected to a series of physicochemical and biological processes, which depend both on the antibiotic nature and soil characteristics. Adsorption/desorption to soil particles and degradation are the main processes that will affect the persistence, bioavailability, and environmental fate of these pollutants, thus determining their potential impacts and risks on human and ecological health. Taking all this into account, a literature review was conducted in order to shed light on the current knowledge about the occurrence of tetracycline and sulfonamide antibiotics in manures/slurries and agricultural soils, as well as on their fate in the environment. For that, the adsorption/desorption and the degradation (both abiotic and biotic) processes of these pollutants in soils were deeply discussed. Finally, the potential risks of deleterious effects on human and ecological health associated with the presence of these antibiotic residues were assessed. This review contributes to a deeper understanding of the lifecycle of tetracycline and sulfonamide antibiotics in the environment, thus facilitating decision-making for the application of preventive and mitigation measures to reduce its negative impacts and risks to public health.

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“…Perceived odour nuisance increases residents’ irritation and health concerns, due to the uncertain public health risks of manure. Moreover, manure could spread antimicrobial resistance to the soil and surface water [ 6 ]. Nearby residents of intensive livestock production have also been shown to be carriers of antibiotic-resistant bacteria, such as Methicillin-resistant Staphylococcus aureus (MRSA), to a greater extent [ 7 ].…”

Section: Resultsmentioning

confidence: 99%

“…In particular, the release of excess nutrients from manure can deteriorate surface water quality, ground water quality, and can cause eutrophication, which impairs terrestrial and aquatic ecosystems, as well as animal health [ 5 ]. Manure can be a source of antimicrobial resistance, particulate matter, and endotoxins [ 6 , 7 ]. Additionally, several studies have detected pathogens in manure, which might reach surface water or air after soil application [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Untangling the Governance of Public Health Aspects of Manure in The Netherlands

Dollmann

Vermeulen

Husman

2021

IJERPH

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The Netherlands is one of the most densely populated countries in terms of people and livestock and is the second largest exporter of agricultural products worldwide. As a result, the Netherlands has a manure surplus. Excess application of manure can lead to environmental problems; therefore, manure needs to be treated and discharged. Manure can contain zoonotic pathogens, but whether exposure to manure and manure treatment also poses a risk to public health is still unknown. This study analysed the regulations, relevant actors, and responsibilities in the complex system of manure and public health in the Netherlands. Interviews and system mapping have demonstrated interlinkages between environmental, economic, and health aspects. Constraints and opportunities for public health protection have been identified. This study reveals the complexity of the Dutch manure policy, its scattered responsibilities, the challenge to deal with uncertainties, and, most importantly, the need for a microbial risk assessment in order to adequately communicate and manage possible risks to protect the health of animals, the environment, and people.

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The impact of manure and soil texture on antimicrobial resistance gene levels in farmlands and adjacent ditches

Cited by 40 publications

References 62 publications

Manure as a Potential Hotspot for Antibiotic Resistance Dissemination by Horizontal Gene Transfer Events

Manure as a Potential Hotspot for Antibiotic Resistance Dissemination by Horizontal Gene Transfer Events

Tetracycline and Sulfonamide Antibiotics in Soils: Presence, Fate and Environmental Risks

Untangling the Governance of Public Health Aspects of Manure in The Netherlands

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